出生年月：1970.11 民族：漢族

學(xué)歷學(xué)位：藥學(xué)博士 職稱：教授

學(xué)科專業(yè)：藥理學(xué)

電話： 027-67842332

電子郵箱：[email protected]

研究方向包括：肝損傷機(jī)制及民族藥物干預(yù),；皮膚創(chuàng)傷修復(fù)的民族藥物藥理學(xué)機(jī)制研究。

1996年畢業(yè)于湖南中醫(yī)學(xué)院（現(xiàn)更名湖南中醫(yī)藥大學(xué)）,，獲醫(yī)學(xué)學(xué)士學(xué)位；同年任湖南株洲市中醫(yī)傷科醫(yī)院五官科醫(yī)師,；1998年9月赴日本國立廣島大學(xué)醫(yī)學(xué)部留學(xué),，于2005年3月，獲博士（藥學(xué)）學(xué)位,；2005年4月至2009年3月任廣島大學(xué)藥學(xué)部助理教授,；

在日本廣島大學(xué)任教期間，主持日本國家自然科學(xué)基金項(xiàng)目2項(xiàng),，并與Nippon Chemiphar,、大鵬藥品工業(yè)和協(xié)和發(fā)酵工業(yè)等幾家主要藥業(yè)公司合作開展扎托洛芬、紫杉醇等4項(xiàng)新藥的研發(fā)工作,。

2009年4月回國,，任中南民族大學(xué)教授，并先后主持完成包括國家自然科學(xué)基金項(xiàng)目在內(nèi)的各級研究項(xiàng)目70余項(xiàng),。

多年來主要從事包括肝癌在內(nèi)腫瘤發(fā)生,、發(fā)展的病理學(xué)機(jī)制及抗腫瘤民族藥物的研究，以及包括修復(fù)皮膚重度創(chuàng)傷和銀屑病,、特應(yīng)性皮炎,、妊娠紋等慢性疑難皮膚疾患等藥用敷料和輕醫(yī)美的護(hù)膚功效性產(chǎn)品研發(fā),，并自主開發(fā)了皮膚自體快速再生與無痕修復(fù)技術(shù)SFO醫(yī)美系列產(chǎn)品（從其應(yīng)用場景而言，要么是獨(dú)一無二,，要么是遙遙領(lǐng)先）,，相關(guān)成果已獲中國發(fā)明專利授權(quán)；在Nanomedicine NBM,、Journal of Agricultural and Food Chemistry,、International Journal of Nanomedicine、Neuropharmacology,、Journal of Ethnopharmacology,、Toxicology Research等期刊上發(fā)表論文70余篇，申報(bào)發(fā)明專利28項(xiàng),，其中24項(xiàng)已授權(quán),，并有糖尿病足潰瘍無痕修復(fù)、快速去除妊娠紋,、美白祛斑等13項(xiàng)技術(shù)已完成科技成果轉(zhuǎn)化,。

近五年的代表性研究論文（*為通訊作者）

1. Zhang Z, Ma SY, Yin X, Li YS, Tang HB*. Topical frankincense treatment for frostbite based on microcirculation improvements. Journal of Ethnopharmacology. 2025, 336:118728. doi: 10.1016/j.jep.2024.118728.

2. Yin X, Gu HW, Ning D, Li YS, Tang HB*. Testosterone Exacerbates the Formation of Liver Cancer Induced by Environmental N-Nitrosamines Exposure: Potential Mechanisms and Implications for Human Health. OncoTargets and Therapy. 2024, 17: 395-409. doi: 10.2147/OTT.S456746.

3. Zhai SY, Gu HW, Wang C, Li YS, Tang HB*. Gynura procumbens and selected metabolites: Amelioration of depressive-like behaviors in mice and risperidone-induced hyperprolactinemia in rats. Biomed Pharmacother. 2024, 173: 116361. doi: 10.1016/j.biopha.2024.116361.

4. Yin X, Li YS, Ye SZ, Zhang T, Zhang YW, Xi Y, Tang HB. Promotion Effect of Coexposure to a High-Fat Diet and Nano-Diethylnitrosamine on the Progression of Fatty Liver Malignant Transformation into Liver Cancer. International Journal of Molecular Sciences. 2023, 24(18): 14162. doi: 10.3390/ijms241814162.

5. Meng SS, Gu HW, Zhang T, Li YS, Tang HB*. Gradual deterioration of fatty liver disease to liver cancer via inhibition of AMPK signaling pathways involved in energy-dependent disorders, cellular aging, and chronic inflammation. Frontiers in Oncology. 2023, 13: 1099624. doi: 10.3389/fonc.2023.1099624.

6. Yin X, Hong J, Tang HB*, Liu M, Li YS. Enhanced healing of oral chemical burn by inhibiting inflammatory factors with an oral administration of shengFu oil. Frontiers in Pharmacology. 2022, 13: 913098. doi: 10.3389/fphar.2022.913098.

7. Wang C, Huang XL, Mu YM, Li YS, He YM, Tang HB*. Synergistic effects of trans-p-coumaric acid isolated from the ethanol extract of Gynura procumbens in promoting intestinal absorption of chlorogenic acid and reversing alcoholic fatty liver disease. Journal of Ethnopharmacology. 2022, 295: 115407. doi: 10.1016/j.jep.2022.115407.

8. Zhang T, Gu HW, Gao JX, Li YS, Tang HB*. Ethanol supernatant extracts of Gynura procumbens could treat nanodiethylnitrosamine-induced mouse liver cancer by interfering with inflammatory factors for the tumor microenvironment. Journal of Ethnopharmacology. 2022, 285: 114917. doi: 10.1016/j.jep.2021.114917.

9. Li YS, Zhang J, Tian GH, Shang HC, Tang HB*. Kirenol, darutoside and hesperidin contribute to the anti-inflammatory and analgesic activities of Siegesbeckia pubescens makino by inhibiting COX-2 expression and inflammatory cell infiltration. Journal of Ethnopharmacology. 2021, 268: 113547. doi: 10.1016/j.jep.2020.113547.

10. Hong J, Chen XZ, Peng YG, Zhang WK, Tang HB*, Li YS. Nanoparticle-Encapsulated Liushenwan Could Treat Nanodiethylnitrosamine-Induced Liver Cancer in Mice by Interfering With Multiple Critical Factors for the Tumor Microenvironment. Frontiers in Pharmacology. 2020, 11: 1052. doi: 10.3389/fphar.2020.01052.

11. Zheng L, Li XY, Huang FZ, Zhang XT, Tang HB*, Li YS, Zhang WK, Li XJ, Tian GH. E?ect of electroacupuncture on relieving central post-stroke pain by inhibiting autophagy in the hippocampus. Brain Research. 2020, 1733: 146680. DOI: 10.1016/j.brainres.2020.146680.

12. Qin QF, Li XJ, Li YS, Zhang WK, Tian GH, Shang HC, Tang HB*. AMPK-ERK/CARM1 signaling pathways affect autophagy of hepatic cells in samples of liver cancer patients. Frontiers in Oncology. 2019, 9: 1247. DOI: 10.3389/fonc.2019.01247.

13. Huang XL, Li XJ, Qin QF, Li YS, Zhang WK, Tang HB*. Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material. Journal of Ethnopharmacology. 2019, 239: 111916. DOI: 10.1016/j.jep.2019.111916.

14. Chen MT, Zhang WK, Liang WL, Li YS, Li XJ, Zhu LH, Tang HB*. Controllable and extra-fast synthesis of bio-applicable silver nanoparticles with Lycium Barbarum L. Materials Technology. 2019, DOI: 10.1080/10667857.2019.1603656

15. Liang WL, Xiao L, Gu HW, Li XJ, Li YS, Zhang WK, Tang HB*. Solid lipid nanoparticle induced apoptosis of macrophages via a mitochondrial-dependent pathway in vitro and in vivo. International Journal of Nanomedicine. 2019, 14: 1–13.

16. Li XJ, Huang FZ, Wan Y, Li YS, Zhang WK, Xi Y, Tian GH, Tang HB*. Lipopolysaccharide Stimulated the Migration of NIH3T3 Cells Through a Positive Feedback Between β-Catenin and COX-2. Frontiers in Pharmacology. 2018, 9: 1487.

17. Zhang MT, Ye XX, Lan W, Yang YL, Wu T, Li YS*, Tang HB. Strategic Combination of Isocratic and Gradient Elution for Simultaneous Separation of Polar Compounds in Traditional Chinese Medicines by HPLC. Journal of Analytical Methods in Chemistry. 2018, 2018: 7569283.

近年主持的國家自然科學(xué)基金項(xiàng)目

1. 基于β-catenin/COX-2炎性環(huán)路探究外用生膚油促進(jìn)糖尿病足病快速修復(fù)的效應(yīng)機(jī)制，2021年國家自然科學(xué)基金面上項(xiàng)目,；

2. 平臥菊三七干預(yù)“β-catenin/COX-2”炎性環(huán)路的防治肝癌機(jī)制研究. 2016年國家自然科學(xué)基金面上項(xiàng)目,；

3. 生膚油促進(jìn)Ⅲ度燙傷皮膚無瘢痕修復(fù)的機(jī)制研究。2013年國家自然科學(xué)基金面上項(xiàng)目,；

4. Wnt/β-catenin信號通路調(diào)控原發(fā)性肝癌發(fā)生的機(jī)制研究. 2011年國家自然科學(xué)基金青年項(xiàng)目,；

5. 非神經(jīng)細(xì)胞對背根神經(jīng)節(jié)神經(jīng)細(xì)胞內(nèi)P物質(zhì)釋放的調(diào)控機(jī)制。2010年國家自然科學(xué)基金面上項(xiàng)目,；