基本信息
出生年月：1990年7月
民族：漢族
郵箱：Qian[email protected]
研究方向
神經(jīng)藥理學(xué)
以離子通道和受體為靶點(diǎn)的藥物作用機(jī)制研究
教育及工作經(jīng)歷
2019年8月至今, 中南民族大學(xué), 藥學(xué)院, 講師
2018年7月—2019年6月, 牛津大學(xué), 藥理學(xué)系,，博士后, 合作導(dǎo)師: Peter Somogyi
2013年9月—2018年6月, 復(fù)旦大學(xué), 生命科學(xué)學(xué)院,，生物物理及生理學(xué)系, 博士, 導(dǎo)師: 梅巖艾
2009年9月—2013年7月, 復(fù)旦大學(xué), 生命科學(xué)學(xué)院，生物科學(xué)專(zhuān)業(yè), 學(xué)士
科研項(xiàng)目
1. 國(guó)家自然科學(xué)基金青年項(xiàng)目,，32000685，條件敲除大麻素1型受體對(duì)海馬區(qū)籃狀神經(jīng)元可塑性的影響和機(jī)制,，2021/01-2023/12,，24萬(wàn)元，在研,，主持
2. 湖北省自然科學(xué)基金青年項(xiàng)目,，2020CFB348,，Neuritin 通過(guò)CB1R 對(duì)中間神經(jīng)元可塑性和小鼠記憶能力的作用和機(jī)制研究,，2020/03-2022/03，5萬(wàn)元,，在研,，主持
3. 國(guó)家自然科學(xué)基金海外及港澳學(xué)者合作研究基金項(xiàng)目，31428003,，Calcineurin-NFATc4參與Neuritin調(diào)控神經(jīng)元Kv4.2表達(dá)和興奮性的分子機(jī)制,，2015/01-2016/12，20萬(wàn)元,，已結(jié)題,，參與
4. 中華人民共和國(guó)科學(xué)技術(shù)部，國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃（973計(jì)劃）項(xiàng)目,，2011CB503700,，電磁輻射危害健康的機(jī)理及醫(yī)學(xué)防護(hù)的基礎(chǔ)研究，2011/01-2015/12,，380萬(wàn)元,，已結(jié)題，參與
代表論文
1. Yongsheng Zhou#, Haobo Tao#, Sisi Lv#, Keqin Liang, Wenyi Shi, Keyi Liu, Yunyun Li, Lvyi Chen, Ling Zhou, Shijin Yin*, Qianru Zhao*. Effects of Kv1.3 knockout on pyramidal neuron excitability and synaptic plasticity in piriform cortex of mice. 2024. Acta Pharmacologica Sinica. 45(10).
2. Qingyuan Wang#, He-Ping Chen#, Haobo Tao#, Xinyang Li, Qianru Zhao*, Ji-Kai Liu*. Penidaleodiolides A and B, Cage-Like Polyketides with Neurotransmission-Regulating Activity from the Soil Fungus Penicillium daleae L3SO. 2024. Organic Letters. 26(36).
3. Yan Zou#, Qianru Zhao#, Xu Zhang, Hui Yu, Yongsheng Zhou, Ziyi Li, Min Xiao, Qiu Xiang, Lirong Zhang, Wenyi Shi, Haobo Tao, Lvyi Chen, Bing Han, Shijin Yin*. The immunosuppressive effects and mechanisms of loureirin B on collagen-induced arthritis in rats. 2023.Frontiers in Immunology. 14:1094649.
4. Shujuan Shi#, Qianru Zhao#, Caihua Ke, Siru Long, Feng Zhang, Xu Zhang, Yi Li, Xinqiao Liu, Hongzhen Hu, Shijin Yin*. Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and KV1.3 Channels. 2021. Frontiers in Pharmacology. 12(685092).
5. Junmei Lu, Zhaoyang Li, Qianru Zhao, Dongdong Liu, Yan-Ai Mei*. Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice. 2021. Neurobiology of Disease. 156(105407).
6. Zhao QR*, Lu JM, Li ZY, Mei YA*. Neuritin promotes neurite and spine growth in rat cerebellar granule cells via L-type calcium channel-mediated calcium influx. 2018. Journal of Neurochemistry. 147(1).
7. Jin-jing Yao#, Qian-Ru Zhao#, Dong-Dong Liu, Chi-Wing Chow, and Yan-Ai Mei*. Neuritin Up-regulates KV4.2 α-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway. 2016. Journal of Biological Chemistry. 291(33).
8. Zhao QR, Lu JM, Yao JJ, Zhang ZY, Ling C, Mei YA*. Neuritin reverses deficits in murine novel object associative recognition memory caused by exposure to extremely low-frequency (50 Hz) electromagnetic fields. 2015. Scientific Reports. 5(11768).
9. He YL, Wang K, Zhao QR, Mei YA*. Cyproheptadine regulates pyramidal neuron excitability in mouse medial prefrontal cortex. 2018. Neuroscience Bulletin. 34(5).
10. Jin-Jing Yao, Qian-Ru Zhao, Jun-Mei Lu, Yan-Ai Mei*. Functions and the related signaling pathways of the neurotrophic factor neuritin. 2017. Acta Pharmacologica Sinica. 39(9).
11. Wang K, Lu JM, Xing ZH, Zhao QR, Hu LQ, Xue L, Zhang J, Mei YA*. Effect of 1.8?GHz radiofrequency electromagnetic radiation on novel object associative recognition memory in mice. 2017. Scientific Reports. 7(44521).
12. Liu DD, Lu JM, Zhao QR, Hu C, Mei YA*. Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels. 2016. Scientific Reports. Jun 29 (6): 28653.
13.Liu DD, Ren Z, Yang G, Zhao QR, Mei YA*. Melatonin protects rat cerebellar granule cells against electromagnetic field-induced increases in Na+ currents through intracellular Ca2+ release. 2014. Journal of Cellular and Molecular Medicine. 305(2).
14. Yao JJ#, Sun J#, Zhao QR, Wang CY, Mei YA*. Neuregulin-1/ErbB4 signaling regulates Kv4.2-mediated transient outward K+ current through the Akt/mTOR pathway. 2013. American Journal of Physiology-Cell Physiology. 18(6).
