姓名：尹榮華
出生年月：1990-10
民族：漢
學(xué)科專業(yè)：藥物化學(xué)
聯(lián)系電話：15887248395
電子郵箱：[email protected]
教育及工作經(jīng)歷：
2020.9—至今 中南民族大學(xué)藥學(xué)院，講師/碩士生導(dǎo)師
2019.1—2020.9 中國科學(xué)院昆明植物研究所,，助理研究員
2015.9—2019.1 中國科學(xué)院昆明植物研究所,，理學(xué)博士
2012.9—2015.6 中國科學(xué)院昆明植物研究所，理學(xué)碩士
2008.9—2012.6 四川農(nóng)業(yè)大學(xué),，農(nóng)學(xué)學(xué)士
研究方向：
天然產(chǎn)物糖化學(xué)及基于結(jié)構(gòu)片段的活性評價(jià)與新藥研發(fā)
科研項(xiàng)目：
1. FG側(cè)鏈結(jié)構(gòu)多樣性及其在強(qiáng)效P-選擇素抑制劑設(shè)計(jì)中的應(yīng)用研究,，國家自然科學(xué)基金面上項(xiàng)目，2025.1-2028.12,，50萬,，主持；
2. 新靶點(diǎn)抗凝藥物FG-11衍生物的設(shè)計(jì)與成藥性研究,，湖北省自然科學(xué)基金面上項(xiàng)目,，2024.3-2026.3，5萬,，主持,；
3. 二糖側(cè)鏈FG的確切結(jié)構(gòu)特征及其對FXase抑制活性的影響研究，國家自然科學(xué)基金青年基金項(xiàng)目,，2020.1-2022.12年,，25萬，主持,；
4. Ludwigothurea grisea來源糖胺聚糖的結(jié)構(gòu)澄清及抗凝構(gòu)效關(guān)系分析,，中央高校基本科研業(yè)務(wù)費(fèi)青年項(xiàng)目,，2021.4-2023.4,，5萬，主持,；
5. FG-8mer抑制內(nèi)源性因子X酶的分子機(jī)制及其機(jī)制相關(guān)的抗凝活性特征,，國家自然科學(xué)基金面上項(xiàng)目,，2018.1-2021.12，56萬,，參加,；
6. 內(nèi)源性F.Xase抑制劑LFG-53新藥臨床前研究，中國科學(xué)院藥物創(chuàng)新研究院自主部署科研項(xiàng)目,，2015.9-2017.8,，192.5萬，參加,。
代表性論文：
1. Ronghua Yin, Ying Pan, Ying Cai, Fan Yang, Na Gao, Dilihumaer Ruzemaimaiti, Jinhua Zhao*. Re-understanding of structure and anticoagulation: Fucosylated chondroitin sulfate from sea cucumber Ludwigothurea grisea. Carbohydrate Polymers. 2022, 294: 119826.
2. Ronghua Yin, Lutan Zhou, Na Gao, Lisha Lin, Huifang Sun, Dingyuan Chen, Ying Cai, Zhili Zuo, Kaifeng Hu, Shengxiong Huang*, Jikai Liu*, Jinhua Zhao*. Unveiling the disaccharide-branched glycosaminoglycan and anticoagulant potential of its derivatives. Biomacromolecules 2021, 22: 1244-1255.
3. Ronghua Yin, Lutan Zhou, Na Gao, Zi Li, Longyan Zhao, Feineng Shang, Mingyi Wu*, Jinhua Zhao*, Oligosaccharides from depolymerized fucosylated glycosaminoglycan: structures and minimum size for intrinsic factor Xase complex inhibition, Journal of Biological Chemistry. 2018, 293:14089-14099.
4. Ronghua Yin, Xue Bai, Tao Feng, Zejun Dong, Zhenghui Li*, and Jikai Liu*, Two new compounds from Xanthium strumarium, Journal of Asian Natural Products Research. 2016, 18: 354-359.
5. Ronghua Yin, Zhenzhu Zhao, Xu Ji, Zejun Dong, Zhenghui Li, Tao Feng*, Jikai Liu*, Steroids and sesquiterpenes from cultures of the fungus Phellinus igniarius, Natural Products and Bioprospecting. 2015, 5:17-22.
6. Ronghua Yin, Zhenzhu Zhao, Heping Chen, Xia Yin, Xu Ji, Zejun Dong, Zhenghui Li, Tao Feng*, Jikai Liu*, Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities, Phytochemistry Letters. 2014, 10:300-303.
7. Lige Cui, Huifang Sun, Xiaolei Shang, Jing Wen, Pengfei Li, Shengtao Yang, Linxia Chen, Xiangyang Huang, Haoyang Li, Ronghua Yin*, and Jinhua Zhao. Purification and structural analyses of sulfated polysaccharides from low-value sea cucumber Stichopus naso and anticoagulant activities of its oligosaccharides. Marine Drugs. 2024; 22: 265.
8. Dilihumaer Ruzemaimaiti#, Huifang Sun#, Jiali Zhang, Chen Xu, Linxia Chen, Ronghua Yin*, Jinhua Zhao*. Oligomer-guided recognition of two fucan sulfate from Bohadschia argus and inhibition of P-selectin binding to its ligand. Carbohydrate Polymers, 2023, 317:121080.
9. Weili Wang#, Hui Mao#, Sujuan Li, Longlong Zhang, Lian Yang, Ronghua Yin*, Jinhua Zhao*. Branched chondroitin sulfate oligosaccharides derived from the sea cucumber Acaudina molpadioides stimulate neurite outgrowth. Marine Drugs. 2022; 20: 653.
10. Xiaomei Li, Huifang Sun, Zimo Ning, Wenjiao Yang, Ying Cai, Ronghua Yin*, Jinhua Zhao*. Mild acid hydrolysis on Fucan sulfate from Stichopus herrmanni: Structures, depolymerization mechanism and anticoagulant activity. Food Chemistry. 2022, 395: 133559.
11. Yan Ma, Na Gao, Zhichuang Zuo, Shanni Li, Wengqi Zheng, Xiang Shi, Qipei Liu, Ting Ma, Ronghua Yin*, Xian Li *, Jinhua Zhao *. Five distinct fucan sulfates from sea cucumber Pattalus mollis: Purification, structural characterization and anticoagulant activities. International Journal of Biological Macromolecules 2021; 186: 535–543.
12. Shanni Li, Wei Zhong, Ying Pan, Lisha Lin, Ying Cai, Hui Mao, Taocui Zhang, Sujuan Li, Ru Chen, Lutan Zhou, Weili Wang, Qinghua Cui *, Ronghua Yin*, Shengxiong Huang*, Jinhua Zhao*. Structural characterization and anticoagulant analysis of the novel branched fucosylated glycosaminoglycan from sea cucumber Holothuria nobilis. Carbohydrate Polymers. 2021, 269: 118290.
13. Xiaomei Li, Shanni Li, Jie Liu, Lisha Lin, Huifang Sun, Wenjiao Yang, Ying Cai, Na Gao, Lutan Zhou, Hongbo Qin*, Ronghua Yin*, Jinhua Zhao*. A regular fucan sulfate from Stichopus herrmanni and its peroxide depolymerization: Structure and anticoagulant activity. Carbohydrate Polymers. 2021, 256: 117513.
14. Lutan Zhou, Ronghua Yin, Na Gao, Huifang Sun, Dingyuan Chen, Ying Cai, Lin Ren, Lian Yang, Zhili Zuo*, Hongbin Zhang*, Jinhua Zhao*. Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis. Pharmacological Research. 2021, 166: 105527
15. Hui Mao1, Ying Cai1, Shanni Li, Huifang Sun, Lisha Lin, Ying Pan, Wenjiao Yang, Zhicheng He, Ru Chen, Lutan Zhou, Weili Wang, Ronghua Yin*, Jinhua Zhao*. A new fucosylated glycosaminoglycan containing disaccharide branches from Acaudina molpadioides: Unusual structure and anti-intrinsic tenase activity. Carbohydrate Polymers. 2020; 245: 116503.
16. Wenjiao Yang1, Dingyuan Chen1, Zhicheng He, Lutan Zhou, Ying Cai, Hui Mao, Na Gao*, Zhili Zuo*, Ronghua Yin*, Jinhua Zhao. NMR characterization and anticoagulant activity of the oligosaccharides from the fucosylated glycosaminoglycan isolated from Holothuria coluber. Carbohydrate Polymers. 2020; 233: 115844.
17. Ying Cai1, Wenjiao Yang1, Xiaomei Li, Lutan Zhou, Zhongjuan Wang, Lisha Lin, Dingyuan Chen, Longyan Zhao, Zhongkun Li, Shubai Liu, Ronghua Yin*, Zhili Zuo*, Na Gao*, Jinhua Zhao, Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments, Carbohydrate Polymers. 2019, 224:115146.
18. Zhicheng He, Lutan Zhou, Lisha Lin, Ronghua Yin*, Jinhua Zhao*, Structure and heparanase inhibitory activity of a new glycosaminoglycan from the slug Limacus flavus, Carbohydrate Polymers. 2019, 220:176-184.
19. Wenqi Zheng, Lutan Zhou, Lisha Lin, Ying Cai, Huifang Sun, Longyan Zhao, Na Gao, Ronghua Yin* Jinhua Zhao*, Physicochemical characteristics and anticoagulant activities of the polysaccharides from sea cucumber Pattalus mollis, Marine Drugs. 2019, 17:198.
20. Feineng Shang1, Na Gao1, Ronghua Yin, Lisha Lin, Chuang Xiao, Lutan Zhou, Zi Li, Steven W. Purcell, Mingyi Wu*, Jinhua Zhao*, Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors, European Journal of Medicinal Chemistry. 2018, 148: 423-435.
21. Wenjiao Yang, Ying Cai, Ronghua Yin, Lisha Lin, Zhongkun Li*, Mingyi Wu*, Jinhua Zhao*, Structural analysis and anticoagulant activities of two sulfated polysaccharides from the sea cucumber Holothuria coluber, International Journal of Biological Macromolecules. 2018, 115: 1055-1062.
22 Ying Cai, Wenjiao Yang, Ronghua Yin, Lutan Zhou, Zhongkun Li*, Mingyi Wu*, Jinhua Zhao*, An anticoagulant fucan sulfate with hexasaccharide repeating units from the sea cucumber Holothuria albiventer, Carbohydrate Research. 2018, 464:12-18.
23. Lisha Lin, Longyan Zhao, Na Gao, Ronghua Yin, Sujuan Li, Huifang Sun, Lutan Zhou, Guiling Zhao, Steven W. Purcell, Jinhua Zhao*, From multi-target anticoagulants to DOACs, and intrinsic coagulation factor inhibitors, Blood Reviews. 2020, 39:100615.
24. Heping Chen, Zhenzhu Zhao, Ronghua Yin, Xia Yin, Tao Feng, Zhenghui Li, Kun Wei, Jikai Liu, Six new vibralactone derivatives from cultures of the fungus Boreostereum vibrans, Natural Products and Bioprospecting. 2014, 4:271-276.
25. Dongbao Hu, Wenxin Li, Zhenzhu Zhao, Tao Feng, Ronghua Yin, Zhenghui Li, Jikai Liu*, Huajie Zhu*, Highly unsaturated pyranone derivatives from the basidiomycete Junghuhnianitida, Tetrahedron Letters. 2014, 55:6530-6533.
26. Jiangbo He, Xiaoman Lv, Zhenghui Li, Shen Zhang, Dongbao Hu, Ronghua Yin, Zhenzhu Zhao, Tao Feng*, Jikai Liu*, Chain terpenoids isolated from cultures of basidiomycete Phellinus sp. Journal of Asian Natural Products Research. 2015, 17:1-5.
