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楊小龍

發(fā)布時間:2019-12-23 瀏覽次數(shù):

 

 

出生年月19839

民族:漢族

職稱:二級教授/博士生導(dǎo)師

學(xué)科專業(yè):藥物化學(xué)

研究方向:天然藥物化學(xué)/天然藥物生物合成與合成生物學(xué)/中藥資源化學(xué)及質(zhì)量控制

電子郵箱[email protected]

 

  • 教育及工作經(jīng)歷

    2019.3-至今:  中南民族大學(xué)藥學(xué)院,,教授/博士生導(dǎo)師

    2016.2-2019.2:重慶大學(xué)藥學(xué)院,,入選重慶大學(xué)百人計劃學(xué)者,研究員/博士生導(dǎo)師

    2014.5-2015.5:德國漢諾威大學(xué)生物分子藥物研究中心,,博士后,,合作導(dǎo)師: Russell J. Cox

    2012.4-2014.4:日本東京大學(xué)藥學(xué)院,JSPS外國特別研究員,,合作導(dǎo)師: Ikuro Abe

    2009.9-2012.4:河北大學(xué)藥學(xué)院,,副教授/碩士生導(dǎo)師

    2004.9-2009.7:中科院昆明植物研究所,博士(碩博連讀),導(dǎo)師:劉吉開教授

    2000.9-2004.7:西北農(nóng)林科技大學(xué),,理學(xué)學(xué)士

     

  • 主要榮譽和獲獎

    2022年:入選國家“萬人計劃”青年拔尖人才

    2020年:入選國家民委中青年英才

    2016年:入選重慶大學(xué)“百人計劃”學(xué)者

    2012年:獲得日本振興學(xué)會(JSPS)外國特別研究員

     

  • 學(xué)術(shù)和社會兼職

    [1] 國際SCI期刊Journal of FungiIF=5.816),,客座編輯(2022.4-2022.12

    [2] 國際期刊Drug Discoveries & Therapeutics,編委(2018-至今)

    [3] 中國民族醫(yī)藥學(xué)會健康產(chǎn)業(yè)分會,,常務(wù)理事(2022.11-至今)

    [4] 中國植物學(xué)會藥用植物及植物藥專業(yè)委員會委員(2023.12-至今)

    [5] 中國菌物學(xué)會菌物化學(xué)專業(yè)委員會,,委員(2018-至今)

    [6] 湖北省生物工程學(xué)會,理事(2021-至今)

    [7] 湖北省植物學(xué)會/武漢市植物學(xué)會,,理事(2021-至今)

    [8] 青海省藏藥研究重點實驗室第二屆學(xué)術(shù)委員會,,委員(2022-至今)

    [9] 青海省高原天然產(chǎn)物工程技術(shù)研究中心,技術(shù)專家(2021-至今)

    [10] 中國科學(xué)院藏藥研究重點實驗室,,客座研究員(2018 -至今)

    [11] 吉林大學(xué),,研究生校外合作導(dǎo)師(2019-至今)

    [12] 廣西科學(xué)院,客座研究員(2020 -至今)

    [13] 新疆農(nóng)業(yè)大學(xué),,碩士生導(dǎo)師(2021-至今)

    [14] 楊凌未來中科環(huán)??萍加邢薰荆夹g(shù)總監(jiān)(2021-至今)

    [15] 新疆阿拉山口市金陸工程項目管理有限公司科技創(chuàng)新板塊,,專家顧問(2022-至今)

    [16] 廣西海洋天然產(chǎn)物與組合生物合成化學(xué)重點實驗室學(xué)術(shù)委員會,,委員(2018 -2020

    [17] 中國科學(xué)院西北高原生物研究所,客座研究員(2018 -2021

    [18] 重慶市紫杉烷類藥物工程技術(shù)研究中心專家委員會副主任 2016.10-2019.3

    [19] 曾擔任重慶大學(xué)藥學(xué)院黨委委員和教工黨支部書記(2016.12-2019.3

    [20] 曾擔任重慶大學(xué)藥學(xué)院藥物分析,、藥物設(shè)計與天然藥物學(xué)系副主任(2018.10-2019.3

    [21] 受邀擔任Advanced Science, J. Am. Chem. Soc., Small, J. Org. Chem., Org. Biomol. Chem., J. Nat. Prod., Front. Microbiol., Int. J. Mol. Sci., J. Pharm. Pharmaco., Metabolites, J. Cell Mol. Med., Phytochemistry等多個SCI期刊審稿人,。

     

     

  • 教學(xué)工作

    累計承擔多門課程教學(xué)工作,本科生課程包括:《有機波譜解析》,、《天然藥物化學(xué)》,、《天然藥物化學(xué)實驗》、《藥理學(xué)實驗》,、《生理解剖學(xué)實驗》和《藥劑學(xué)實驗》,,研究生課程包括:《高等天然藥物化學(xué)》和《高等有機化學(xué)》;發(fā)表國家級核心教研論文2篇,;作為校級第一個跨學(xué)科科普教學(xué)實踐團隊骨干參與制作了2部科普課程《科普·神奇世界的解密者》和《帶你認識中醫(yī)藥》,,上線學(xué)習(xí)強國平臺;指導(dǎo)大學(xué)生創(chuàng)新訓(xùn)練項目/學(xué)科競賽20余項,,獲國家級/省部級獎項7項,。

     

  • 承擔科研或人才項目

    [1] 國家“萬人計劃”青年拔尖人才計劃190萬,2023.1-2025.12,,主持,,在研。

    [2] 國家重點研發(fā)計劃中醫(yī)藥現(xiàn)代化研究重點專項子課題白術(shù),、菊花和百合產(chǎn)地溯源檢測數(shù)據(jù)集構(gòu)建2020YFC1712703),,266.73萬,2020.10-2022.9,,主持,,結(jié)題。

    [3] 國家重點研發(fā)計劃“食品營養(yǎng)與安全關(guān)鍵技術(shù)研發(fā)”專項子課題:風(fēng)險因子智能挖掘與多維表征(2023YFF1104001),,95萬元,,2023. 12 -2027.12,主持,,在研,。

    [4] 國家自然科學(xué)基金面上項目:基于MDM2/mTOR雙靶點的植物內(nèi)生真菌中新穎結(jié)構(gòu)抗三陰乳腺癌活性分子發(fā)現(xiàn)及其作用機制研究(82473805)48萬元,,2025.01-2028.12,,主持,在研,。

    [5] 國家自然科學(xué)基金面上項目基因組挖掘驅(qū)動的翹孢霉屬真菌中隱形聚酮-非核糖體肽類化合物的發(fā)現(xiàn)及其生物合成研究(82073714),,55萬元,2021.01-2024.12,,主持,,在研。

    [6] 國家自然科學(xué)基金面上項目表觀遺傳修飾策略驅(qū)動的11株植物內(nèi)生真菌中新型抗耐藥菌活性分子合成潛能的挖掘(81872755),, 57萬元,,2019.01-2022.12,主持,,結(jié)題,。

    [7] 國家自然科學(xué)青年基金:擬盤多毛孢內(nèi)生真菌中抗腫瘤活性先導(dǎo)化合物的發(fā)現(xiàn)及活性評價 (21202033) 25萬元,,2013.01-2015.12,,主持,結(jié)題,。

    [8] 國家民委中青年英才培養(yǎng)計劃項目:兩株藥用植物內(nèi)生真菌中新型抗腫瘤藥物先導(dǎo)結(jié)構(gòu)的發(fā)現(xiàn)及其作用機制研究,,10萬元,2021.01-2022.12,,主持,,結(jié)題。

    [9] 中央高?;究蒲袠I(yè)務(wù)費專項資金重點培育項目:六種藥用植物內(nèi)生真菌中新型抗耐藥性細菌藥物先導(dǎo)化合物的發(fā)現(xiàn)(CZP20007),, 40萬,2020.1-2022.12,,主持,,結(jié)題。

    [10] 河北省自然科學(xué)基金:特殊生境真菌中結(jié)構(gòu)新奇化學(xué)成分的發(fā)現(xiàn)及抗真菌活性研究 (C2012201047) 3萬元,,2012.01-2015.01,,主持,結(jié)題,。

    [11] 中國科學(xué)院藏藥研究重點實驗室開放課題:青藏高原特境真菌資源庫構(gòu)建及藥用活性分子發(fā)現(xiàn) (2017-ZJ-Y11),,5萬元,2018.11-2019.12,,主持,,結(jié)題。

    [12] 重慶大學(xué)百人計劃學(xué)者引進啟動基金:特殊生境真菌資源庫的構(gòu)建及新穎結(jié)構(gòu)藥用活性物質(zhì)的挖掘 (0236011104401),, 100萬元,,2016-2019,主持,,結(jié)題,。

    [13] 橫向課題:抗菌消炎類物質(zhì)的發(fā)現(xiàn)及其在新型煙草中的應(yīng)用研究, 79萬元,,2019.9-2021.2,,主持,結(jié)題,。

    [14] 橫向課題:病害丹參應(yīng)激化學(xué)成分及其抗病活性研究,,25萬元,2018.12-2019.12,,主持,,結(jié)題。

    [15] 橫向課題:一株假單胞細菌代謝產(chǎn)物的活性檢測及分離鑒定, 15萬元,,2020.3-2021.1,,主持,結(jié)題,。

    [16] 橫向課題:產(chǎn)紫衫醇微生物的發(fā)現(xiàn)及產(chǎn)業(yè)化研究(02360126051001),,100萬元,2016.05-2017.12,,主持,,結(jié)題。

    [17] 橫向課題:浙產(chǎn)鐵皮石斛活性成分提取和分離研究(HZY23027),,30萬元,,2023.3-2023.12,主持,,結(jié)題,。

     

     

  • 著作

    [1] 《民族植物資源化學(xué)與生物活性研究》,,20222月,化學(xué)工業(yè)出版社,,第一主編

    [2]《天然產(chǎn)物結(jié)構(gòu)解析》,,201711月,科學(xué)出版社,,編委

    [3] 《科普:神奇世界的解密者》數(shù)字課程,,20234月,,電子工業(yè)出版社,,副主編

    [4] 《武陵山區(qū)藥用及食用植物資源-湖北冊》,202310月,,化學(xué)工業(yè)出版社,,副主編

     

  • 論文發(fā)表

    迄今,在Angew. Chem. Int. Ed., Chem. Sci., Nat. Prod. Rep., Org. Lett., Cell Death Dis., J. Nutri. Biochem.等本領(lǐng)域權(quán)威期刊上發(fā)表學(xué)術(shù)論文120余篇,,其中SCI收錄論文101篇,。

  • 5年代表性SCI論文

    [1] Qing-Pei Liu#, Shuai-Biao Gao#, Jin Fang#, Yi-Fu Gong, Yi-Ling Zheng, Yao Xu, Dan Zhang, Jia-Yuan Wei, Liang-Xiu Liao, Ming Yao, Wen-Jing Wang, Xiao-Le Han, Fu-Sheng Chen, Istva?n Molna?r*, Xiao-Long Yang*. Novel fungal diphenyl ether biosynthetic gene clusters encode a promiscuous oxidase for elevated antibacterial activities. Chemical Science, 2024, 15: 14248.

    [2] Ming Yao, Wei Yang, Jing Li, Cheng-Yun Huang, Jin Fang, Su-Lu Qin, Shu-Zhi Liu, Xiao-Long Yang*. Total synthesis and stereochemical assignment of talaroconvolutin A and talarofuranone: gram-scale synthesis of ferroptosis inducer talaroconvolutin A. Chinese Journal of Chemistry, 2024, 42, 1509-1514.

    [3] Ting Wu#, Wen-Jing Wang#, Zhou-Yuan Li, Yi-Tian Liu, Tian-Ping Yu, Shuang-Ge Li, Hong-Zhi Du, Chun Gui, Da-Hui Liu*, Xiao-Long Yang*. Anti-inflammatory discovery of sesquiterpenoids and a jasmonic acid derivative from Artemisia stolonifera. Phytochemistry, 2024, 223:114120.

    [4] Liang-Xiu Liao, Jun-Guo Huang, Qing-Pei Liu, Ming Yao, Wen-Jing Wang*, Xiao-Long Yang*. Two new quinazoline alkaloids produced by Aspergillus versicolor and their antimicrobial activities. Journal of Asian Natural Products Research, 2024, 26: 320-327.

    [5] Xu Chen, Zheng-Ping Che, Jia-Jia Wu, Cheng Zeng, Xiao-long Yang*, Lin Zhang*, Zheng-Hong Lin*. Sterigmatocystin induces autophagic and apoptotic cell death of liver cancer cells via downregulation of XIAP. Heliyon, 2024, 10: e29567.

    [6] Shu-Zhi Liu#, Wen-Jing Wang#, Qing-Pei Liu, Ming Yao, Liang-Xiu Liao, Shuai-Biao Gao, Yi Yu, Xiao-Long Yang*. Emerindanols A and B: two bipolyhydroindenol sesterterpenes with unprecedented 5/6-6/5 coupled ring system discovered by genome mining. Organic Letters, 2024, 26:4475-4479

    [7] Xin-Tian Wang, Heng-Ye Chen, Yao Fan, Wei Lan, Juan He, Hai-Yan Fu*, Xiao-Long Yang*. Atractylodin targeted visual fluorescence sensor based on N-acetyl-L-cysteine capped CdTe QDs for the rapid identification of the geographical origin of Atractylodis Rhizome. Microchemical Journal, 2024, 201: 110508.

    [8] Qing-Pei Liu, Dan Zhang, Shuai-Biao Gao, Xian-Hua Cai, Ming Yao, Yao Xu, Yi-Fu Gong, Ke Zheng, Yi-Gui Mao, Li-Yan Yang, Deng-Feng Yang, Istva?n Molna?r*, Xiao-Long Yang*. Didepside formation by the nonreducing polyketide synthase Preu6 of Preussia isomera requires the interaction of the starter acyl transferase and the thioesterase domains. Angewandte Chemie International Edition, 2023, 135: e202214379.

    [9] Yong Xia#*, Long-Quan Xiang#, Ming Yao, Zhi-Ying Ai, Wei Yang, Jian-Hua Guo, Shu-Hao Fan, Ning Liu, Xiao-Long Yang*. Proteomics, transcriptomics, and phosphoproteomics reveal the mechanism of talaroconvolutin-A suppressing bladder cancer via blocking cell cycle and triggering ferroptosis. Molecular & Cellular Proreomics, 2023, 22: 100672.

    [10] Liang-Xiu Liao, Ze-Diao Huang, Fu-Ting Wei, Wen-Jing Wang*, Xiao-Long Yang*. New chromone analog and pyrrole alkaloid produced by Penicillium sclerotiorum and their antibacterial activity. Journal of Asian Natural Products Research, 2023, 25:225-230.

    [11] Ming Yao, Xiu-Yun Bai, Fa-Min Wen, Kai-Hui Liu, Jian Yang, Heng-Ye Chen*, Xiao-Long Yang*. Accurate origin identification of Chinese white Chrysanthemi Flos by analysis of C, N, O, H stable isotope ratios and mineral elements combined with chemometrics. Journal of Food Composition and Analysis, 2023, 124:105703

    [12] Su-Lu Qin, Jia-Xin Ding, Cheng-Yun Huang, Jing Li, Ming Yao, Qing-Pei Liu, Wen-Jing Wang*, Xiao-Long Yang*. Secondary metabolites from Pseudallescheria boydii and their anti-melanoma activity. Tetrahedron, 2023, 147: 133663.

    [13] Jing Li*, Sheng-Ping Jiang, Cheng-Yun Huang, Bai-Hui Lu, Xiao-Long Yang*. Identification and validation of genes associated with aging- related cardiovascular disease. The FASEB Journal, 2023, 38: e23370.

    [14] Jing Li#, Ying-Jiang Zhang#, Xin Zeng, Ya-Hong Cheng, Liu Tang, Hong Ding*, Xiao-Long Yang*. Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1. Journal of Nutritional Biochemistry, 2022, 99:108862.

    [15] Qing-Pei Liu#,*, Dan Zhang#, Yao Xu, Shuai-Biao Gao, Yi-Fu Gong, Xian-Hua Cai, Ming Yao*, Xiao-Long Yang*. Cloning and functional characterization of the polyketide synthases based on genome mining of Preussia isomera XL-1326. Frontiers in Microbiology, 2022, 13: 819086

    [16] Peng-Jie Xian#, Shu-Zhi Liu#, Wen-Jing Wang, Sheng-Xiang Yang, Zhang Feng*, Xiao-Long Yang*. Undescribed specialised metabolites from the endophytic fungus Emericella sp. XL029 and their antimicrobial activities. Phytochemistry, 2022, 202: 113303.

    [17] Wen-Jing Wang#, Liang-Xiu Liao#, Ze-Diao Huang, Fu-Ting Wei, Xiao-Long Yang*. Thiazolo[5,4-b]pyridine alkaloid and seven ar-bisabol sesquiterpenes produced by the endophytic fungus Penicillium janthinellum. ACS Omega, 2022, 7: 35280-35287.

    [18] Jing Li, Xin Zeng, Xiao-Long Yang*, Hong Ding*. Lycopene ameliorates skin aging by regulation of the insulin resistance pathway and activation of SIRT1, Food & Function, 2022, 13:11307.

    [19] Li Wang, Yi-Gui Mao, Xiang Zeng, Na Liu, Chao-Fei NiuXin-Xin Li, Bi-Ji Ma*, Lan-Ping Guo*, Xiao-Long Yang*. Structure and bioactivities of a novel polysaccharide extracted from Dendrobium huoshanense by subcritical water. Frontiers in Nutrition, 2022, 9:877871.

    [20] Xiao-Le Han*,#, Fan Yu#, Jia-Wen Lei, Jia-Hua Zhu, Hai-Yan Fu, Jun-Cheng Hu, Xiao-Long Yang*. Pb2+ responsive Cu-In-Zn-S quantum dots with low cytotoxicity. Frontiers in Chemistry, 2022, 10: 821392.

    [21] Liang-Xiu Liao, Ze-Diao Huang, Fu-Ting Wei, Wen-Jing Wang*, Xiao-Long Yang*. New chromone analog and pyrrole alkaloid produced by Penicillium sclerotiorum and their antibacterial activity. Journal of Asian Natural Products Research, 2022, doi: /10.1080/10286020.2022.2084585.

    [22] Jing-Fang Xiao, Qing-Hua Ma, Rui-Li Cai, Jing-Ya Miao, Ze-Xuan Yan, Xiao-Long Yang*, Ye-Miao Chen*. Acute anti-cancer activity of crude extracts from two endophytic fungi Chaetomium cochliodes and Penicillium sp. in cancer cell lines and mice. International Journal of Pharmacology, 2022, 18: 1583-1592.

    [23] Jing Li, Sheng-Ping Jiang, Cheng-Yun Huang, Xiao-long Yang*. Atraric acid ameliorates hyperpigmentation through the down-regulation of MC1R/PKA/CREB signaling pathway. International Journal of Molecular Sciences, 2022. (In press)

    [24] Qing-Pei Liu, Si-Yu Zhong, Xin-Rui Wang, Shuai-Biao Gao, Xiao-Long Yang*, Fu-Sheng Chen*, István Molnár*. An integrated approach to determine the boundaries of the azaphilone pigment biosynthetic gene cluster of Monascus ruber M7 grown on potato dextrose agar. Frontiers in Microbiology, 2021, 12:680629.

    [25] Jun-Yan Qu, Cheng Zeng, Ting-Ting Zou, Xu Chen, Xiao-Long Yang*, Zheng-Hong Lin*. Autophagy induction by trichodermic acid attenuates endoplasmic reticulum stress-mediated apoptosis in colon. International Journal of Molecular Sciences, 2021, 22: 5566.

    [26] Qing-Lin Mou, Sheng-Xiang Yang, Ting-Xiang, Wen-Wen Liu, Jian Yang, Lan-Ping Guo*, Wen-Jing Wang*, and Xiao-Long Yang*. New cytochalasan alkaloids and cyclobutane dimer from an endophytic fungus Cytospora chrysosperma in Hippophae rhamnoides and their antimicrobial activities. Tetrahedron Letters, 2021, 87: 153207.

    [27] Peng-Jie Xian, Heng-Ye Chen, Zhang Feng*, Wei Zhao*, Xiao-Long Yang*. Capsulactone: a new 4-hydroxy-α-pyrone derivative from an endophytic fungus Penicillium capsulatum and its antimicrobial activity. Journal of Asian Natural Products Research, 2021, 23: 1100-1106.

    [28] Wen-Ting Zhao#, Xiong Shi#, Peng-Jie Xian, Zhang Feng*, Jian Yang*, Xiao-Long Yang*. A new fusicoccane diterpene and a new polyene from the plant endophytic fungus Talaromyces pinophilus and their antimicrobial activities. Natural Product Research, 2021, 35:124-130.

    [29] Ze-Diao Huang, Wen-Jing Wang, Xiao-Le Han*, Xiao-Long Yang*. Three new hydroxyphenylacetic acid derivatives and a new alkaloid from an endophytic fungus Mortierella sp. in Epimedium acuminatum Franch. and their antibacterial activity. Chemistry & Biodiversity, 2021, 18: e202100741.

    [30] Yong Xia*, Shu-Zhi Liu, Chang-Lin Li, Zhi-Ying Ai, Wen-Zhi Shen, Wen-Qi Ren, Xiao-Long Yang*. Discovery of a novel ferroptosis inducer - talaroconvolutin A - killing colorectal cancer cells in vitro and in vivo. Cell Death & Disease, 2020, 11:988.

    [31] Wen-Ting Zhao#, Qing-Pei Liu#, Heng-Ye Chen, Wei Zhao*, Yuan Gao*, Xiao-Long Yang*. Two novel eremophylane acetophenone conjugates from Colletotrichum gloeosporioides, an endophytic fungus in Salvia miltiorrhiza. Fitoterapia, 2020, 141: 104474.

    [32] Hai-Li Chen#, Wen-Ting Zhao#, Qing-Pei Liu, Heng-Ye Chen, Wei Zhao*, Deng-Feng Yang*, Xiao-Long Yang*. (±)-Preisomide: A new alkaloid featuring a rare naturally occurring tetrahydro-2H-1,2-oxazin skeleton from an endophytic fungus Preussia isomera by using OSMAC strategy. Fitoterapia, 2020, 141: 104475.

    [33] Sheng-Xiang Yang#, Jing-Fang Xiao#, Ting-Kai Liu, Ze-Diao Huang, Xiang Li, Ye-Miao Chen#, Xiao-Long Yang*. A 3D screening approach identifies the compound epitajixanthone hydrate as a new inhibitor of cancer cell growth and invasion. Anti-cancer Drugs, 2020, 31(9):890-899.

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