出生年月：1987年3月
民族：漢
職稱：講師
學(xué)科專業(yè)：藥物化學(xué)/藥理學(xué)
研究方向：基于天然多糖及其結(jié)構(gòu)片段的創(chuàng)新藥物研發(fā)
電子郵箱：[email protected]
學(xué)習(xí)經(jīng)歷：
2013.9-2016.7,，中國科學(xué)院昆明植物研究所，藥物化學(xué),，博士
2009.9-2012.6,，中南大學(xué),，生藥學(xué),，碩士
2005.9-2009.7,，濟(jì)寧醫(yī)學(xué)院,，藥物制劑，學(xué)士
工作經(jīng)歷：
2016.8--至今,，中南民族大學(xué)，藥學(xué)院,，講師/碩士研究生導(dǎo)師
2012.7-2013.9,，中國科學(xué)院昆明植物研究所，植物化學(xué)與西部植物資源持續(xù)利用國家重點(diǎn)實(shí)驗(yàn)室,，人才助手
研究領(lǐng)域：
主要從事天然產(chǎn)物糖化學(xué)及其藥理學(xué)研究,，包括糖類活性成分化學(xué)、結(jié)構(gòu)修飾,、活性篩選及靶點(diǎn)機(jī)制研究,。
以第一作者或通訊作者(含共同通訊)在Carbohydr Polym、Eur J Med Chem,、Int J Biol Macromol,、Thromb Haemost、Arterioscl Throm Vas 等國際期刊發(fā)表學(xué)術(shù)論文二十余篇,；作為主要發(fā)明人申請并獲得中國,、美國、日本等國內(nèi)外授權(quán)專利二十余項(xiàng),。
作為核心骨干參加了新靶點(diǎn)抗凝藥物LFG53/YB209(內(nèi)源性凝血因子X酶抑制劑)研發(fā),，主要承擔(dān)藥物原料及制劑制備工藝、新藥目標(biāo)成分確認(rèn),、質(zhì)量研究,、結(jié)構(gòu)確證,、雜質(zhì)研究，并參與構(gòu)-效關(guān)系研究及藥代動(dòng)力學(xué)研究,、知識(shí)產(chǎn)權(quán)保護(hù)與新藥注冊等工作,。目前，LFG53/YB209已作為First-in-class類新藥取得中國NMPA和美國FDA的臨床批件(許可),。
主持或參加科研項(xiàng)目：
[1] 國家自然科學(xué)基金青年項(xiàng)目,，81703374，FG依賴HC-II的抗凝血酶活性的結(jié)構(gòu)序列研究, 2018/01-2020/12,，主持
[2] 中央高?；究蒲袠I(yè)務(wù)青年項(xiàng)目，巖藻糖化糖胺聚糖抑制P/L-選擇素及其對炎性肺損傷的保護(hù)作用,，2023/04-2025/04,，主持
[3] 國家自然科學(xué)基金面上項(xiàng)目，82073725,，基于FG結(jié)構(gòu)片段的P-選擇素抑制劑發(fā)現(xiàn)及其抗血栓活性研究,，2021/01-2024/12，參與
[4] 科學(xué)技術(shù)部,，國家科技重大專項(xiàng),，2017ZX09101003-003-027，抗血栓藥物LFG臨床前研究,，2018/01-2020/12,，參與
[5] 中國科學(xué)院，中國科學(xué)院戰(zhàn)略生物資源服務(wù)網(wǎng)絡(luò)計(jì)劃,，ZSTH-020,，P-選擇素拮抗劑FD-016的血管保護(hù)與抗血栓活性評(píng)價(jià)及其轉(zhuǎn)化研究，2016/09-2018/09,，參與
[6] 云南省自然科學(xué)基金重點(diǎn)項(xiàng)目,，2013FA046，因子X酶抑制劑FGAG衍生物的構(gòu)效關(guān)系及應(yīng)用價(jià)值評(píng)價(jià),，2013/09-2015/10,，參與
學(xué)術(shù)論文：
1. Sun HF, Yang SS, Li PF, Shang XL, Wang P, Zhang JL, Yuan L, Yin RH, Gao N*, Zhao JH*. Comparative assessment of APTT reagents for evaluating anticoagulant sensitivity of fucosylated glycosaminoglycans (FGs) derived from sea cucumbers. Marine Drugs, 2023, 21, 568.
2. Lan D, Zhang JL, Shang XL, Yu LJ, Xu C, Wang P, Cui LG, Cheng NQ, Sun HF, Ran JN, Sha L, Yin RH, Gao N*, Zhao JH*. Branch distribution pattern and anticoagulant activity of a fucosylated chondroitin sulfate from Phyllophorella kohkutiensis. Carbohydrate Polymers, 2023, 321: 121304.
3. Zuo ZC, He ZC, Ma Y, Xu C, Tao XL, Ning ZM, Gao L, Ailainuer R, Gao N*, Zhao JH*. Structure characterization of a highly branched galactan from the slug Vaginulus alte and its utilization by human gut microbiota. International Journal of Biological Macromolecules, 2023, 236: 123935.
4. Li SJ, Wang WL, Lin LS, Yang L, Cai Y, Yang XZ, Zhang TC, Xiao C, Yan H, Gao N*, Zhao JH*. Oligosaccharide blocks PAR1 (proteinase-activated receptor 1)-PAR4–mediated platelet activation by binding to thrombin exosite II and impairs thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 2023, 43: 253-266.
5. Tao XL, Wang WL, Shi X, Lan D, Mao H, Ning ZM, Gao L, Zuo ZC, Xu C, Yang ZQ, Wang Y, Zuo ZL*, Gao N*, Zhao JH*. Peroxidative depolymerization of fucosylated glycosaminoglycan: Bond-cleavage pattern and activities of oligosaccharides. Carbohydrate Polymers, 2022, 295: 119855.
6. Gao L, Xu C, Tao XL, Zuo ZC, Ning ZM, Wang LH, Gao N*, Zhao JH*. Structure elucidation of fucan sulfate from sea cucumber Holothuria fuscopunctata through a bottom up strategy and the antioxidant activity analysis. International Journal of Molecular Sciences, 2022, 23(9): 4488.
7. Ning ZM, Wang P, Zuo ZC, Tao XL, Gao L, Xu C, Wang ZY, Wu B*, Gao N*, Zhao JH. A fucan sulfate with pentasaccharide repeating units from the sea cucumber Holothuria floridana and its anticoagulant activity. Marine Drugs, 2022, 20(6): 377.
8. Liu XX, Ning ZM, Zuo ZC, Wang Pin, Yin RH, Gao N*, Wu B, Zhao JH. The glycosidic bond cleavage and desulfation investigation of fucosylated glycosaminoglycan during mild acid hydrolysis through structural analysis of the resulting oligosaccharides. Carbohydrate Research, 2022, 511: 108493.
9. Chen R, Yin RH, Li SN, Pan Y, Mao H, Cai Y, Lin LS, Wang WL, Zhang TC, Zhou LT, Gao N*, Luo XD*, Zhao JH*. Structural characterization of oligosaccharides from free radical depolymerized fucosylated glycosaminoglycan and suggested mechanism of depolymerization. Carbohydrate Polymers, 2021, 270: 118368.
10. Shi X#, Guan R#, Zhou LT, Zuo ZC, Tao XL, Wang P, Zhou YR, Yin RH, Zhao LY*, Gao N* Zhao JH. Structural characterization and heparanase inhibitory activity of fucosylated glycosaminoglycan from Holothuria floridana. Marine Drugs, 2021, 19: 162.
11. Sun HF#, Gao N#, Ren L, Liu S, Lin LS, Zheng WQ, Zhou LT, Yin RH, Zhao JH*. The components and activities analysis of a novel anticoagulant candidate dHG-5. European Journal of Medicinal Chemistry, 2020, 207: 112796.
12. Gao N, Chen R, Mou RR, Xiang JY, Zhou K, Li Z, Zhao JH*. Purification, structural characterization and anticoagulant activities of four sulfated polysaccharides from sea cucumber Holothuria fuscopunctata. International Journal of Biological Macromolecules, 2020, 164: 3421–3428.
13. Cai Y#, Yang WJ#, Li XM, Zhou LT, Wang ZJ, Lin LS, Chen DY, Zhao LY, Li ZK. Liu SB, Yin RH *, Zuo ZL *, Gao N*, Zhao JH. Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments. Carbohydrate Polymers, 2019, 224: 115-146.
14. Guan RW#, Peng Y, Zhou LT, Zheng WQ, Liu XX, Wang P, Yuan QX, Gao N*, Zhao LY*, Zhao JH*. Precise structure and anticoagulant activity of fucosylated glycosaminoglycan from Apostichopus japonicus: analysis of its depolymerized fragments. Marine Drugs, 2019, 17: 195.
15. Liu XX, Zhang ZX, Mao H, Wang P, Zuo ZC, Gao L, Shi X, Yin RH, Gao N*, Zhao JH*. Characterization of the hydrolysis kinetics of fucosylated glycosaminoglycan in mild acid and structure of the resulting oligosaccharides. Marine Drugs, 2020, 18: 286.
16. Zhou LT#, Gao N#, Sun HF, Xiao C, Yang L, Lin LS, Yin GH, Li Z, Zhang HB*, Ji X*, Zhao JH*. Effects of native fucosylated glycosaminoglycan, its depolymerized derivatives on intrinsic factor Xase, coagulation, thrombosis, and hemorrhagic risk. Thrombosis and Haemostasis, 2020, 120(4): 607-619.
17. Yang WJ#, Chen DY#, He ZC, Zhou LT, Cai Y, Mao H, Gao N*, Zuo ZL*, Yin RH*, Zhao JH. NMR characterization and anticoagulant activity of the oligosaccharides from the fucosylated glycosaminoglycan isolated from Holothuria coluber. Carbohydrate Polymers, 2020, 233: 115844.
18. Cai Y#, Yang WJ#, Li XM, Zhou LT, Wang ZJ, Lin LS, Chen DY, Zhao LY, Li ZK, Liu SB, Yin RH*, Zuo ZL*, Gao N*, Zhao JH. Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments. Carbohydrate Polymers, 2019, 224: 115146.
19. Xu L#, Gao N#, Xiao C, Lin LS, Purcell SW, Wu MY*, Zhao JH*. Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition. European Journal of Medicinal Chemistry, 2018, 154: 133-143.
20. Shang FN#, Gao N#, Yin RH, Lin LS, Xiao C, Zhou LT, Li Z, Purcell SW, Wu MY*, Zhao JH*. Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors. European Journal of Medicinal Chemistry, 2018, 148: 423-435.
21. Gao N#, Lu F#, Xiao C, Yang L, Chen J, Zhou K, Wen DD, Li Z, Wu MY, Jiang JM, Liu GM*, Zhao JH*. β-Eliminative depolymerization of the fucosylated chondroitin sulfate and anticoagulant activities of resulting fragments. Carbohydrate Polymers, 2015, 127(3): 427–437.
22. Gao N, Wu MY, Liu S, Lian W, Li Z, Zhao JH*. Preparation and characterization of O-acylated fucosylated chondroitin sulfate from sea cucumber. Marine Drugs, 2012, 10: 1647–1661.
主要發(fā)明專利：
[1] Zhao JH, Li ZG, Gao N, Wu MY, Chen YM, Zhao LY, Wu YS, Li Z, Xiao C, Zheng SL, Nan ZY, Zhou JB, Xu JP, Zhou LT, Guo YF, Qin HB, Liu JK. Oligosaccharide compound for inhibiting endogenous coagulation factor X-enzyme complex, and preparation method therefor and uses thereof. JP6980018 [日本授權(quán) 2021-11-18]
[2] Zhao JH, Wu MY, Gao N, Li Z, Lai SS, Zhao LY. Low-molecular-weight glycosaminoglycan derivative containing terminal 2, 5-anhydrated talose or derivative thereof. CA2908959 [加拿大授權(quán) 2020-10-6]
[3] Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof. CA2907887 [加拿大授權(quán) 2020-10-6]
[4] Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof. EP2980103 [歐洲授權(quán) 2020-11-4]
[5] Zhao JH, He JX, Wu MY, Liu ZW, Gao N, Zhao LY, Li Z, Lu F, Xu L. Fuc3S4S substituted oligoglycosaminoglycan and preparation method thereof. IN349399 [印度授權(quán) 2020-10-6]
[6] Zhao JH, Wu MY, Gao N, Li Z, Lai SS, Zhao LY. Low molecular weight glycosaminoglycan derivative containing terminal 2,5-anhydrated talose or derivative thereof. JP 6248179 B2 [日本授權(quán) 2017-11-24]
[7] Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof. US9896517B2 [美國授權(quán) 2018-02-20]
[8] Zhao JH, He JX, Wu MY, Liu ZW, Gao N, Zhao LY, Zi Li Z, Lu F, Xu L, et al. Fuc3S4S substituted oligo-glycosaminoglycan and preparation method thereof. JP6472808 B2 [日本授權(quán) 2019-02-01]
[9] 趙金華, 李振國, 高娜, 吳明一, 陳艷明, 趙龍巖, 務(wù)勇圣, 李姿, 肖創(chuàng), 鄭順亮, 南志遠(yuǎn), 周劍波, 許建萍, 周路坦, 郭亞芳, 秦紅波, 劉吉開. 一種抑制內(nèi)源性凝血因子X酶復(fù)合物的寡糖化合物及其制備方法與用途. ZL201710018307.8 [授權(quán) 2021-11-23]
[10] 趙金華, 尹榮華, 高娜, 周路坦, 劉吉開.一種寡糖化合物及其藥學(xué)上可接受的鹽、制備方法及應(yīng)用. ZL202010410013.1 [授權(quán) 2021-10-26]
[11] 何金星, 李姿, 高娜. 一種抗菌組合物,、其制備方法及其在抗菌紙制備中的用途. ZL201410077645.5 [授權(quán) 2017-12-19]
[12] 趙金華, 何金星, 吳明一, 趙龍巖, 劉峙汶, 楊蓮, 李姿, 高娜, 肖創(chuàng), 徐麗, 陳鈞, 周路坦. 一種抑制內(nèi)源性因子X酶活性的寡糖類化合物及其藥物組合物. ZL 201410549676.6 [授權(quán) 2017-12-01]
[13] 趙金華, 何金星, 吳明一, 劉峙汶, 高娜, 趙龍巖, 李姿, 盧鋒, 徐麗, 肖創(chuàng), 楊蓮, 陳鈞, 周路 坦, 彭 文 烈, 劉 吉 開. Fuc3S4S 取 代 的 低 聚 糖 胺 聚 糖 及 其 制 備 方 法. ZL201410007855.7 [授權(quán) 2016-08-31]
[14] 趙金華, 吳明一, 高娜, 李姿, 賴森森, 趙龍巖. 一種含末端 2,5-脫水塔羅糖或其衍生物的低分子量糖胺聚糖衍生物. ZL 2013101274 7.0 [授權(quán) 2015-11-4]
[15] 趙金華, 劉吉開, 吳明一, 高娜, 盧鋒, 李姿. 一種低分子量糖胺聚糖衍生物及其藥物組合物和其制備方法與應(yīng)用. ZL 2013100 99800.9 [授權(quán) 2015-09-16]
