出生年月：1984-09

民族：漢

職稱：講師

學(xué)科專業(yè)：藥劑學(xué)

郵箱：[email protected]

教育經(jīng)歷：

2013.9-2017.6 ：華中科技大學(xué)同濟(jì)醫(yī)學(xué)院，醫(yī)學(xué)博士

2007.9-2010.6： 四川大學(xué)華西藥學(xué)院,，醫(yī)學(xué)碩士

2003.9-2007.6: 重慶醫(yī)科大學(xué)藥學(xué)院,，理學(xué)學(xué)士

工作經(jīng)歷：

2010.9-2013.7：江蘇恒瑞醫(yī)藥股份有限公司，項(xiàng)目負(fù)責(zé)人

2018.3至今： 中南民族大學(xué)藥學(xué)院,，講師

主要研究方向：

1. 靶向納米藥物傳遞系統(tǒng)的研究

2. 藥物性肝損傷機(jī)制研究

科研項(xiàng)目：

1. Toll樣受體9介導(dǎo)的信號(hào)通路在何首烏致肝損傷中的作用和機(jī)制研究,，湖北省自然科學(xué)基金青年項(xiàng)目（2020CFB351），2020-2022,，主持

2. 負(fù)載姜黃素的pH敏感水凝膠通過NEDD4介導(dǎo)PTGS2降解緩解鐵死亡治療炎癥性腸病的機(jī)制研究（CZQ22009）,，中央高校基本科研業(yè)務(wù)費(fèi)專項(xiàng)資金自科青年項(xiàng)目,，主持

3. 何首烏致肝損傷的機(jī)理研究（YZZ18017）,，校科學(xué)基金項(xiàng)目,，主持

4. 口服多生物響應(yīng)性雙層微凝膠用于潰瘍性結(jié)腸炎的治療（CZZ21010）,，中央高校基本科研業(yè)務(wù)費(fèi)專項(xiàng)資金自科重點(diǎn)項(xiàng)目,，主要參與人

5. 中藥蘄艾精油包埋技術(shù)及經(jīng)皮給藥系統(tǒng)的研究與開發(fā)（QZY19001）,，地廳級(jí)自科一般項(xiàng)目，主要參與人

6. 民族藥藥效物質(zhì)基礎(chǔ)（YZF20004）,，“國家基金申報(bào)學(xué)術(shù)工作坊”自科項(xiàng)目,，主要參與人

代表性研究成果：

(1) Kang Li^#; Si Luqin^#; Rao Jing; Li Dan; Wu Ya; Wu Sanlan; Wu Minghui; He Sijie; Zhu Wenwen;Wu Yang; Xu Jiaqiang; Li Gao; Huang Jiangeng ; Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes, Toxicology in Vitro, 2017, 40:313-323

(2) Zhang Shangwen^#; Kang Li^#; Hu Sheng; Hu jie; Fu Yanping; Hu Yan; Yang Xinzhou ;Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease, International Journal of Biological Macromolecules, 2021, 167: 1598-1612

(3) Hu Yan; Zhang Shangwen; Wen Zhijie; Fu Hudie; Hu jie; Ye Xuexin; Kang Li; Li Xiaojun;Yang Xinzhou ; Oral delivery of curcumin via multi-bioresponsive polyvinyl alcohol and guar gum based double-membrane microgels for ulcerative colitis therapy, International journal of biological macromolecules, 2022, 221(11): 806-820

(4) Kang Li^#; Li Dan^#; Jiang Xin^#; Zhang Yao; Pan Minhong; Hu Yixin; Si Luqin; Zhang Yongjun;Huang Jiangeng ; Hepatotoxicity of the Major Anthraquinones Derived From Polygoni Multiflori Radix Based on Bile Acid Homeostasis, Frontiers in Pharmacology, 2022, 13

(5) Zhijie Wen^#; Li Kang^#; Hudie Fu; Shengpeng Zhu; Xuexin Ye; Xuedan Yang; Shangwen Zhang; Jie Hu; Xiaojun Li; Lvyi Chen; Yan Hu; Xinzhou Yang ; Oral delivery of porous starch-loaded bilayer microgels for controlled drug delivery and treatment of ulcerative colitis, Carbohydrate Polymers, 2023, 314: 120887

(6) Hu Yan, Zhu Shengpegn, Ye Xue, Wen Zhijie, Fu Hudie, Kang Li, Aikemu A, Yang Xinzhou. Oral delivery of sodium alginate/chitosan bilayer microgels loaded with Lactobacillus rhamnosus GG for targeted therapy of ulcerative colitis. Int J Biol Macromol. 2024 Oct;278(Pt 3):134785.

(7) Hu Jie; Wen Zhijie; Fu Hudie,;Yang Xinzhou, Zhu Shengpeng, Kang Li, Yang Xinzhou, Hu Yan. Construction of redox-sensitive liposomes modified by glycyrrhetinic acid and evaluation of anti-hepatocellular carcinoma activity. Chem Phys Lipids. 2023 May;252:105292.