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楊新洲

發(fā)布時間:2019-03-11 瀏覽次數(shù):

楊新洲教授

中南民族大學 藥學院,,武漢市洪山區(qū)民族大道182號,,武漢430074,,中國

Tel.: 027-67841196 (辦公); E-mail: [email protected]

 

 

 

 

 

個人信息

民族:漢族

職稱: 教授

學科專業(yè):中藥/民族藥

研究方向:中藥和民族藥的藥效物質(zhì)及作用機制研究,,以及中藥和民族藥資源的開發(fā)與利用

電話:027-67841196

電子郵箱:[email protected]ORCID: 0000-0003-1697-2923

學習經(jīng)歷

1995.9-1999.7:同濟醫(yī)科大學,獲理學學士學位(藥學)

1999.9-2002.7:華中科技大學,獲醫(yī)學碩士學位(藥物化學)

2002.9-2005.7:中國科學院上海藥物研究所,獲理學博士學位(有機化學)

工作經(jīng)歷

2005.7-2007.9:中國科學院上海藥物研究所,,助理研究員

2007.9-2009.1:瑞士巴塞爾大學藥學院從事博士后研究工作(合作導師,Matthias Hamburger教授)

2009.1-2010.12: 澳大利亞格里菲斯大學新藥發(fā)現(xiàn)研究所,,Research Fellow (團隊負責人,,Ronald J Quinn教授,澳大利亞科學與工程院(ATSE)院士)

2010.12-至今: 中南民族大學藥學院從事教學和科研工作,,副教授,,教授

重要學術(shù)組織任職情況

國家自然科學基金會評專家、國家自然科學基金網(wǎng)絡(luò)評審專家,;期刊Frontiers in Pharmacology(中科院二區(qū),,IF5.83)的Associate Editor;《整合藥學雜志》英文刊(Journal of Holistic Integrative Pharmacy,,JHIP),、Molecules客座編輯;Carbohydrate Polymers,、Acta Pharmacologica Sinica,、Organic LettersBioorganic Chemistry,、Journal of Natural Products,、Journal of Agricultural and Food ChemistryPhytochemistry,、International Journal of Biological Macromolecules,、PhytomedicineFood & Function,、Industrial Crops & Products,、Foods,、Journal of Functional FoodsBiomedicine & Pharmacotherapy,、Scientia Horticulture,、Food Science and Human WellnessFood & Nutrition Research,、Journal of the Science of Food and Agriculture,、Frontiers in PharmacologyJournal of Ethnopharmacology,、Bioorganic & Medicinal ChemistryPlanta Medica,、Bioorganic & Medicinal Chemistry Letters,、Tetrahedron LettersPhytochemistry Letters,、Helvitica Chimica Acta,、Natural Product ResearchBMC Complementary and Alternative Medicine等五十多個國際醫(yī)藥專業(yè)刊物的審稿人

其他任職

國際標準化組織中藥標準委員會(ISO/TC249)中方工作專家,、中國民族醫(yī)藥學會科研分會常務理事,、中國民族醫(yī)藥學會資源分會常務理事、中國民族醫(yī)藥學會土家醫(yī)藥學分會常務理事,、武漢市中藥及天然藥物專業(yè)委員會委員,、瑞士化學會會員、澳大利亞皇家化學會會員等

學術(shù)研究

1,、民族藥物層級庫的構(gòu)建

   課題組深入民族地區(qū)(鄂西,、新疆、青海,、西藏,、廣西、貴州,、云南)廣泛收集了1000余種中草藥和民族藥物,,構(gòu)建了中草藥和民族藥物樣本庫(含1000種藥材樣本)→藥材提取物庫(3000個提取物,一種藥材含石油醚,、乙酸乙酯,、甲醇三個提取物)→預組分化庫(正在建設(shè))→民族藥物成分庫(1000個以上民族藥單體成分)。依據(jù)新藥研發(fā)的經(jīng)典規(guī)律—Lipinski五規(guī)則,,我們采用特殊的柱色譜前處理技術(shù)構(gòu)建預組分化庫,。

2、抗糖尿病藥理活性及機制研究

長期從事天然藥物抗糖尿病活性成分篩選與機制研究工作,。利用最新發(fā)展的前沿技術(shù)(基因編輯CRISPR-Cas9,、CETSA,、靶蛋白垂釣)探索與藥物與靶蛋白間相互作;構(gòu)建基于L6細胞IRAP-mOrange熒光轉(zhuǎn)染促GLUT4轉(zhuǎn)膜活性篩選方法,,實現(xiàn)藥物抗糖尿病活性快速篩選,;已建立多種飲食干預、基因表達干預的糖尿病動物,、細胞模型,,全面研究藥物作用效果;利用基因工程技術(shù)構(gòu)建基因沉默/過表達載體調(diào)控信號分子表達,,實現(xiàn)藥物作用機制研究,。

3、基于中草藥和民族藥物庫的抗腫瘤活性化合物的發(fā)現(xiàn)

   長期從事天然藥物抗多種腫瘤活性與機制研究,;團隊已成熟構(gòu)建體內(nèi)外抗腫瘤活性物質(zhì)篩選平臺,,實現(xiàn)組分或單體化合物體抗腫瘤藥效系統(tǒng)評價;團隊將結(jié)合腫瘤發(fā)病的熱門靶點,,探索天然藥物抗腫瘤活性的新機制,;采用MTTCKK-8方法篩選上述構(gòu)建的中草藥和民族藥物提取物庫,在各種柱色譜分離純化技術(shù)的基礎(chǔ)上結(jié)合活性導向,、質(zhì)譜導向以及核磁共振氫譜導向技術(shù),,快速、高效,、靶向地發(fā)現(xiàn)抗腫瘤活性成分,。

3、中藥和民族藥化學成定性和定量分析及溯源研究

應用UPLC-Q-TOF/MS結(jié)合UNIFI數(shù)據(jù)庫快速自動表征中藥和民族藥的化學成分,,并用UPLC-TQ-MS/MS方法對主要成分進行準確定量,。最后通過結(jié)合生物活性篩選方法確定主要藥效成分;熟練應用UPLC-Q-TOF/MSUPLC-TQ-MS/MS技術(shù),,利用非靶向代謝組學的方法區(qū)分中藥材和民族藥不同品種,,明確同一中藥材不同品系在化學組成上的共性及區(qū)別;基于UPLC-MS1HNMR等技術(shù),,結(jié)合非靶向代謝組學(PCA,、PLS-DAOPLS-DA)的方法對中藥和民族藥材進行產(chǎn)地溯源,,以區(qū)分不同產(chǎn)地的中藥材和民族藥及評價其質(zhì)量,。

4、中藥和民族藥新劑型研究

進行中藥靶向遞藥系統(tǒng),,中藥制劑體內(nèi)藥動學及成藥性評價,;中藥新劑型與新制劑的研究開發(fā)。在從事中藥及民族藥復方制劑的開發(fā)工作中,,其參與企業(yè)研發(fā)的兩個中藥六類新藥“川七鎮(zhèn)腦寧膠囊”和“赤母婦炎寧膠囊”已獲臨床批件,。

5,、中藥和民族藥新品種選育

主持選育蘄艾新品種蘄特1號,參與選育蘄艾新品種2個(蘄特2號和3號),。

獲獎情況

1.        楊新洲1/8),,吳寧,顧成剛,,盧汝梅,,陳少軍,趙平,,王強,,任永申. 基于中藥及民族藥物庫和活性導向的新藥發(fā)現(xiàn)策略及其應用,湖北省科學技術(shù)獎(科技進步獎)二等獎(2018J-214-2-086-073-R01),,201812.

2.        楊新洲1/8),,宋萍,盧汝梅,,吳寧,趙平,,袁經(jīng)權(quán),,林親雄,舒廣文. 基于中藥及民族藥物庫和活性導向的藥效物質(zhì)高效發(fā)現(xiàn)策略及其應用,,中國民族醫(yī)藥學會科學技術(shù)獎(科技進步獎)一等獎,,20227.

3.        萬定榮,楊新洲2/8),,陳科力,,葛月賓,聶晶,,焦玉,,林親雄,吳紹敏. 南方特色民族藥資源調(diào)查鑒定,、質(zhì)量控制與規(guī)范化應用,,教育部高等學校科學研究優(yōu)秀成果獎(科學技術(shù)進步獎)二等獎(2018-294),,20191.

4.        萬定榮,,楊新洲2/8)等.《中國毒性民族藥志》,國家民族醫(yī)藥科學技術(shù)獎一等獎,,201911.

5.         萬定榮,,楊天鳴,楊新洲3/10),,葛月賓,,劉新橋,,林親雄,帥麗,,付海燕,,陳科力,陳家春. 湖北省土家族藥材資源,、鑒定和質(zhì)量控制研究, 國家民族醫(yī)藥科學技術(shù)獎(自然科學獎)二等獎(2014-11-24-ZR02-503),,201411

榮譽

●  20232024年入選斯坦福大學“全球前2%頂尖科學家榜單”

●  2024年入選新疆“天池英才”特聘教授

●  2013年入選CTXZ計劃

●  2014年入選第7批武漢市東湖高新3551人才計劃

●  2019年入選國家民委中青年人才計劃

●  2013 中南民族大學大學生創(chuàng)新創(chuàng)業(yè)項目優(yōu)秀指導老師

●  2013 汪超,碩士研究生國家獎學金(指導老師)

●  2014 楊靜,,碩士研究生國家獎學金(指導老師)

●  2014 第七屆全國大學生藥苑論壇三等獎(指導老師)

●  2014 研究生汪超入選2014年國家建設(shè)高水平大學公派博士研究生項目(澳大利亞Griffith大學,,世界排名202

●  2015 汪超,湖北省優(yōu)秀碩士論文(指導老師)

●  2015 中南民族大學優(yōu)秀網(wǎng)絡(luò)輔助教學二等獎

●  2016 黃密,,碩士研究生國家獎學金(指導老師)

●  2016 中南民族大學“十佳青年教工”

●  2016 教育部審核評估先進個人

●  2017 段歡,,湖北省優(yōu)秀學士論文(指導老師)

●  2017 柯蕊芳,第五屆全國醫(yī)藥院校藥學/中藥學專業(yè)大學生實驗技能大賽一等獎(指導老師)

●  2017 陳麗,,第五屆全國醫(yī)藥院校藥學/中藥學專業(yè)大學生實驗技能大賽三等獎(指導老師)

●  2017 研究生黃密入選2017年國家建設(shè)高水平大學公派博士研究生項目(瑞典Lund大學,,QS世界排名79

●  2017 鄧世豪,碩士研究生國家獎學金(指導老師)

●  2018 黃蘊,,碩士研究生國家獎學金(指導老師)

●  2018 陳麗,,2018年度湖北省大學生優(yōu)秀科研成果獎二等獎(指導老師)

●  2018 王佳琳,2018年度湖北省大學生優(yōu)秀科研成果獎三等獎(指導老師)

●  2019 研究生黃蘊入選2019年國家建設(shè)高水平大學公派博士研究生項目(丹麥Copenhagen大學,,QS世界排名75

●  2019 呂奕兵,,碩士研究生國家獎學金(指導老師)

●  2019 呂奕兵,中南民族大學三好研究生標兵

●  2019 郝吉,,碩士研究生國家獎學金(聯(lián)合指導老師)

●  2019 張進燕(廣西中醫(yī)藥大碩士生聯(lián)培),,碩士研究生國家獎學金(聯(lián)合指導老師)

●  2019 張進燕(廣西中醫(yī)藥大碩士生聯(lián)培),暨南大學讀博

●  2020 呂奕兵,,中南民族大學優(yōu)秀碩士論文(指導老師)

●  2020 呂奕兵,,中南民族大學優(yōu)秀碩士畢業(yè)生(華中科大讀博)

●  2020 章仁(武科大碩士生聯(lián)培),華中科大讀博

●  2020 陳豪(廣西中醫(yī)藥大碩士生聯(lián)培),,成都中醫(yī)藥大學讀博

●  2021 馬遠任,,中南民族大學優(yōu)秀碩士論文(指導老師)(中國海洋大學讀博)

●  2021 梁旭(廣西中醫(yī)藥大碩士生聯(lián)培),南中醫(yī)-中科院上海藥物所讀博

●  2021 吳超群(聯(lián)合指導老師),,中山大學讀博

●  2022 周童曦,,碩士研究生國家獎學金(指導老師)

●  2022 周童曦,香港理工大學讀博(QS世界排名65

●  2023 程海濤,,碩士研究生國家獎學金(指導老師)

●  2023 魏灃(石河子大學聯(lián)培),,碩士研究生國家獎學金(聯(lián)合指導老師)

●  2023 唐萍(石河子大學聯(lián)培),碩士研究生國家獎學金(聯(lián)合指導老師)

  2023 魏灃(石河子大學聯(lián)培),中科院昆植所讀博

承擔的項目(中南民族大學)

1.        維吾爾藥“歐帕日混”調(diào)控AMPK-GLUT4通路的抗糖尿病藥效物質(zhì)基礎(chǔ)及作用機制研究(國家自然科學基金面上項目82374144),,2024.1-2027.12,,58萬,主持,,在研

2.        三種槐屬民族藥抗糖尿病藥效物質(zhì)基礎(chǔ)及作用機制研究(國家自然科學基金國際交流合作項目81911540487),,2019.7-2021.610萬,,主持,,結(jié)題

3.        民族藥石上柏作用于喉癌COX-2EGFR 多靶標的活性成分及作用機制研究(國家自然科學基金面上項目81774000),2018.1-2021.12,,66萬,,主持,結(jié)題

4.        基于GLUT4SGLT2雙靶點的槐屬藥用植物抗糖尿病藥效物質(zhì)基礎(chǔ)及作用機制研究(國家自然科學基金面上項目81573561),,2016.1-2019.12,,66萬元,主持,,結(jié)題

5.        基于GLUT4靶點的苦參抗糖尿病活性物質(zhì)和作用機制研究( 國家自然科學基金青年項目81102798),,2012.1-2014.1222萬,,主持,,結(jié)題

6.        藏藥鬼箭錦雞兒基于GLUT4靶點的抗糖尿病藥效物質(zhì)基礎(chǔ)及作用機制研究,青海省自然科學基金重點項目(2023-0302-ZJC-0147),,2023.1-2024.12,到賬經(jīng)費15萬,,第二完成人,,在研

7.        新疆阿魏的藥效物質(zhì)基礎(chǔ)與作用機制研究,新疆自治區(qū)區(qū)域協(xié)同創(chuàng)新專項上海合作組織科技伙伴計劃及國際科技合作計劃項目(2023E01019),,2023.1-2025.12,,第二完成人,在研

8.        大宗維吾爾民族藥質(zhì)量標準提升,、藥效物質(zhì)和作用機制及開發(fā)示范研究,,國家民委中青年英才計劃項目MZR200032019.9-2021.9,,10萬,,主持,結(jié)題

9.        典型天然香料關(guān)鍵成分剖析方法研究,,湖北中煙工業(yè)有限責任公司委托橫向課題HZY210572021JCXL3JS2C003),,2021.8-2022.1279萬,,主持,,結(jié)題

10.    維吾爾藥材破布木果有效成份分離與作用機制的研究,,新疆自治區(qū)區(qū)域協(xié)同創(chuàng)新專項上海合作組織科技伙伴計劃及國際科技合作計劃項目(2020E01016),2021.4-2022.12,, 到賬15萬,,第二完成人,結(jié)題

11.    基于核磁共振譜和活性導向的藏藥抗肝癌藥效物質(zhì)和作用機制研究,,青海省重點研發(fā)與轉(zhuǎn)化計劃科技合作項目科技合作專項(2020-HZ-802),,2020.1-2022.12,到賬經(jīng)費22.75萬,,第二完成人,,結(jié)題

12.    西黃蓍膠等三種藥材質(zhì)量標準研究,和田維吾爾藥業(yè)股份有限公司委托橫向課題(HZY20015),,2020.8-2021.12,,16.8萬,主持,,結(jié)題

13.    煙用三乙酸甘油酯關(guān)鍵組分分析及品控指標研究,,湖北中煙工業(yè)有限責任公司委托橫向課題HZY190362019.9-2020.6,,34.8萬,,主持,結(jié)題

14.    武漢市應用基礎(chǔ)研究項目中藥五類新藥竹黃降糖有效部位藥效學研究2017060201010217),,2017.8-2019.12,,15萬,主持,,結(jié)題

15.    基于Caspase 3 靶點和預分離組分庫的藏藥抗肝癌藥效物質(zhì)及其作用機制研究(青海省自然科學基金重點項目2016-ZJ-908),,2016.1-2018.12,到賬經(jīng)費7萬(分配15萬),,排名第二,,結(jié)題

16.    新藥中藥六類川七鎮(zhèn)腦寧膠囊開發(fā)研究(武漢市國家東湖高新區(qū)3551光谷創(chuàng)新人才計劃項目BX219),2014.5-2017.5,,100萬(企業(yè)配套400萬),,主持,結(jié)題

17.    基于GLUT4靶點的廣豆根抗糖尿病活性物質(zhì)和作用機制研究(中科院上海藥物藥物研究所新藥研究國家重點實驗室開放基金SIMM1403KF-07),,2014.4-2015.4,,8萬,主持,,結(jié)題

18.    苦參抗糖尿病有效部位臨床前藥效和作用機制研究(武漢市科技計劃項目青年晨光計劃項目2013070104010028),,2013.1-2014.1210萬,主持,,結(jié)題

19.    基于GLUT4靶點的苦參抗糖尿病活性物質(zhì)和作用機制研究(人事部留學回國人員擇優(yōu)資助項目BZY12006),,2012.1-2014.123萬,,主持,,結(jié)題

20.    基于GLUT4靶點的苦參抗糖尿病活性物質(zhì)和作用機制研究(中南民族大學人才引進基金項目YZ211002),2011.1-2013.12,,90萬,,主持,結(jié)題

21.    基于鄂西土家藥物庫和GLUT4靶點的抗糖尿病活性成分的發(fā)現(xiàn),,中央高?;究蒲袠I(yè)務費專項資金資助項目,2019.1-2020.12,, 6萬,,主持,在研

22.    中藥和民族藥物中活性成分快速發(fā)現(xiàn)的新技術(shù)及在中藥新藥研發(fā)中的應用(中央高?;究蒲袠I(yè)務費專項資金資助項目CZP17060,,獎項培育),2017.7-2018.7,,5萬,,主持,結(jié)題

23.    藏藥馬先蒿質(zhì)量標準研究(中央高?;究蒲袠I(yè)務費專項資金資助項目3212014CZW14051),,2013.5-2015.55.5萬,,主持,,結(jié)題

24.    基于土家藥物庫和GLUT4靶點的抗糖尿病活性成分發(fā)現(xiàn)策略(湖北省民族藥物現(xiàn)代化工程技術(shù)研究中心開放課題2015ZD004),2015.5-2017.4,,6萬,,主持,,結(jié)題

25.    基于壯,、傣、土家等民族醫(yī)特色病種藥物的有效性及質(zhì)量評價關(guān)鍵技術(shù)研究(十二五國家科技支撐計劃項目2012BAI27B06),,2011.1-2015.12,,分配經(jīng)費36萬,科研骨干人員,,結(jié)題

26.    藏藥預分離組分庫建立與抗肝癌活性研究(青海省自然科學基金重點項目2012-Z-904),,2012.1-2014.12,分配經(jīng)費10萬,排名第二,,結(jié)題

27.    傣藥榼藤子皂苷類成分的抗二型糖尿病活性和藥理研究(湖北省自然科學基金一般項目BZY11061),,2013.1-2014.123萬,,排名第四,,結(jié)題

28.    基于民族藥物預分離組分庫的抗前列腺癌的先導化合物發(fā)現(xiàn)策略(中南民族大學學生科研基金重點項目KYCX110009E),2012.5-2013.5年,,0.6萬,,指導老師,結(jié)題

29.    民族藥物內(nèi)生菌抗癌活性成分的發(fā)現(xiàn)(國家級大學生創(chuàng)新項目GXX14211),,2013.4-2014.4,,2萬,指導老師,,結(jié)題

30.    苦參降糖活性部位毒理學研究(湖北省大學生創(chuàng)新項目SCX15006),,2014.4-2015.41萬,,指導老師,,結(jié)題

31.    基于GLUT4靶點的苦豆子抗糖尿病活性物質(zhì)和作用機制研究(湖北省大學生創(chuàng)新項目SCX15025),2015.4-2016.4,,1萬,,指導老師,結(jié)題

32.    喜樹內(nèi)生真菌中抗肝癌活性化合物的發(fā)現(xiàn)(國家級大學生創(chuàng)新項目GCX1728),,2017.4-2018.4,,2萬,指導老師,,結(jié)題

以前參與的項目

1.        后基因組時代新藥發(fā)現(xiàn)關(guān)鍵技術(shù)研究(上海市自然科學基金重點項目036505003),,2003.1-2005.12,參與人

2.        建立來源于傳統(tǒng)中草藥的天然產(chǎn)物庫(中科院上海藥物研究所-諾華公司國際合作項目),,2002-2008,,參與人

3.        Discovering of GABAA receptor modulators from medicinal plants and fungal materials (瑞士國家自然基金項目),2005-2008,,主要參與人

4.        Discovering of anticancer leads from medicinal plants and fungal materials based on HPLC fractionation extract library(瑞士國家自然基金項目),,2006-2009,主要參與人

5.        Discovery new Antimalarial lead from nature bank Medicines for Malaria Venture慈善基金項目),,2008-2010,,參與人

6.        輝瑞工業(yè)合作項目“Pfizer Collaboration-Anti-Infective Project”2009-2011,,主要參與人

代表性論文(目前已發(fā)表論文250余篇,,其中SCI論文180余篇,,中科院二區(qū)及以上60余篇,*通訊,,#共同一作)

Publications

1.        Tongqing Li#, Huijian Chen#, Yan Guo, Mi Huang, Pengxin Liu, Ainiwaer Aikemu, Nabijan Mohammadtursun, Xin Pan*, Xinzhou Yang*. Nuciferine restores autophagy through the PI3K AKT mTOR pathway, alleviating EMT and renal fibrosis in diabetic nephropathy. Journal of Agricultural and Food Chemistry, 2025, https://doi.org/10.1021/acs.jafc.4c08844. (中科院一區(qū)Top, IF 5.94)

2.         Huijian Chen, Pengxin Liu, Xin Pan, Mi Huang, Tongqing Li, Yan Guo, Zongran Pang*, Nabijan Mohammadtursun, Xinzhou Yang*. Downregulation of collagen IV deposition and ITGB1-FAK signaling pathway to inhibit adipogenesis: A novel mechanism of swertiamarin in treating type 2 diabetes mellitus. International Journal of Biological Macromolecules, 2025, 299, 140048. (中科院一區(qū)Top, IF 7.70)

3.        Feng Wei#, Wenting Zhang#, Shiwen Kang, Pengxin Liu, Yudi Yao, Wenqi Liu, Ainiwaer Aikemu*, Kejian Pang*, Xinzhou Yang*. Phenolic Constituents with Glucose Uptake and GLUT4 Translocation Bioactivities from the Fruits of Cordia dichotoma. Journal of Agricultural and Food Chemistry, 2024, 72 (29): 16298-16311. https://pubs.acs.org/10.1021/acs.jafc.4c02672. (中科院一區(qū)Top, IF 5.94)

4.        Yan Hu, Shengpeng Zhu, Xuexin Ye, Zhijie Wen, Hudie Fu, Jiasi Zhao, Mohan Zhao, Xinxi Li, Yuqing Wang, Xiaojun Li, Li Kang, Aikemu Ainiwaer*, Xinzhou Yang*. Oral delivery of sodium alginate/chitosan bilayer microgels loaded with Lactobacillus rhamnosus GG for targeted therapy of ulcerative colitis. International Journal of Biological Macromolecules, 2024, 278: 134785. (中科院一區(qū)Top, IF 7.70)

5.        Huijian Chen, Pengxin Liu, Ruitao Yu, Nabijan Mohammadtursun, Ainiwaer Aikemu*, Xinzhou Yang*. Swertiamarin ameliorates type 2 diabetes by activating β3-adrenergic receptor/UCP1 thermogenic signals in adipose. Phytomedicine, 2024, 156190. https://doi.org/10.1016/j.phymed.2024.156190. (中科院一區(qū)Top, IF 6.70)

6.        Jinwen Huang, Huiqi Wang, Huaqun Chen, Zidong Liu, Xuedong Zhang, Hao Tang, Shiying Wei, Wangting Zhou, Xinzhou Yang, Yonghong Liu, Longyan Zhao, Qingxia Yuan. Structural analysis and in vitro fermentation characteristics of an Avicennia marina fruit RG-I pectin as a potential prebiotic. Carbohydr. Polym., 2024, 338: 122236. doi: 10.1016/j.carbpol.2024.122236. (中科院一區(qū)Top, IF 10.70)

7.        Ya-Nan Liu#, Hong-Xia Zhu#, Tao-Yu Li, Xinzhou Yang*, Xiao-Jun Li*, Wei Kevin Zhang*. Lipid nanoparticle encapsulated oleic acid induced lipotoxicity to hepatocytes via ROS overload and the DDIT3/BCL2/BAX/Caspases signaling in vitro and in vivo. Free Radical Biology and Medicine, 2024, 222: 361-370. (中科院二區(qū)Top, IF7.10)

8.        Yudi Yao#, Yang Chen#, Huijian Chen, Xin Pan, Xiaojun Li, Wenqi Liu, Yerlan Bahetjan, Binan Lu, Kejian Pang, Xinzhou Yang*, Zongran Pang*. Morus nigra fruits extract inhibits hepatic adipogenesis in T2DM mice by regulating AMPK/mTOR pathway to improve diabetes and dyslipidemia. Journal of Ethnopharmacology, 2024, 319, 117216. (中科院二區(qū)Top, IF5.40)

9.        Wenqi Liu, Siwen Kang, Ni Zheng, Yerlan Bahetjan, Huijian Chen, Guangzhong Yang*, Xinzhou Yang*. A composition of ursolic acid derivatives from Ludwigia hyssopifolia induces apoptosis in throat cancer cells via the Akt/mTOR and mitochondrial signaling pathways and by modulating endoplasmic reticulum stress. Journal of Ethnopharmacology, 2024, 319, 117351, https://doi.org/10.1016/j.jep.2023.117351. (中科院二區(qū)Top, IF5.40)

10.    Ping Zhao, Shunhua Zhong, Jingya Liao, Jingze Tao, Yanhong Yao, Ping Song*, Xinzhou Yang*. Caragana jubata ethanol extract ameliorates the symptoms of STZ-HFD-induced T2DM mice by PKC/GLUT4 pathway. Journal of Ethnopharmacology, 2025, 339, 119171. (中科院二區(qū)Top, IF5.40)

11.    Ting Zhang, Xiangluan Wan, Changfu Liu, Jing Luo, Dingrong Wan, Xinzhou Yang*. A comparative UPLC-MS-based metabolomics approach for distinguishing four different cultivars of Qiai (Artemisia argyi Lévl. et Van. in Qichun). Arabian Journal of Chemistry, 2024, 17: 105452. https://doi.org/10.1016/j.arabjc.2023.105452. (中科院二區(qū)Top, IF6.13)

12.    Shu-Lan Liu, Xue-Ling Huang, Shun-Hua Zhong, Yong-Hui Ma, Feng Wei, Yu-Ye Zhang, Jin Li,*, Ke-Jian Pang, Ping Zhao, Xin-Zhou Yang*. Seven undescribed compounds from dried flower buds of Ochrocarpus longifolius. Phytochemistry, 2024, 114307.   https://doi.org/10.1016/j.phytochem.2024.114307. (中科院二區(qū), IF 3.43)

13.    Pu Guo, Qirong Lu, Siyi Hu, Yaqin Yang, Xinru Wang, Xinzhou Yang*, Xu Wang*. Daucosterol confers protection against T-2 toxin induced blood-brain barrier toxicity through the PGC-1α-mediated defensive response in vitro and in vivo. Journal of Hazardous Materials, 2023, 459, https://doi.org/10.1016/j.jhazmat.2023.132262. (中科院一區(qū)Top,,IF14.22

14.    Zhijie Wen, Li Kang, Hudie Fu, Shengpeng Zhu, Xuexin Ye, Xuedan Yang, Shangwen Zhang, Jie Hu, Xiaojun Li, Lvyi Chen, Yan Hu*, Xinzhou Yang*. Oral delivery of porous starch-loaded bilayers microgels for controlled drug delivery and treatment of ulcerative colitis. Carbohydrate Polymers, 2023, 314: 120887. (中科院一區(qū)Top, IF10.49)

15.    Tongxi Zhou, Guanjun Song, Di Tian, Qinghua Liu, Jinhua Shen, Xinzhou Yang*, Ping Zhao*. Nuciferine relieves type 2 diabetes mellitus via enhancing GLUT4 expression and translocation. Food Science and Human Wellness, 2023, 2023, 12: 2040-2051. (中科院一區(qū)Top, IF8.02)

16.    Lulu Zhang, Xiuteng Zhou, Huijian Chen, Liangzhen You, Ting Zhang, Meng Cheng, Yudi Yao, Xin Pan*, Xinzhou Yang*. Antidiabetic effect of an ethyl acetate extract of Morus alba fruits on type 2 diabetes mice induced by a high-fat diet and streptozotocin and its underlying mechanism. Journal of Ethnopharmacology, 2023, 313: 116475. (中科院二區(qū)Top, IF5.40)

17.    Yudi Yao#, Yang Chen#, Huijian Chen, Xin Pan, Xiaojun Li, Wenqi Liu, Yerlan Bahetjan, Binan Lu, Kejian Pang, Xinzhou Yang*, Zongran Pang*. Morus nigra fruits extract inhibits hepatic adipogenesis in T2DM mice by regulating AMPK/mTOR pathway to improve diabetes and dyslipidemia. Journal of Ethnopharmacology, 2024, 319: 117216. (中科院二區(qū)Top, IF5.40)

18.    Yerlan Bahetjan, Wenqi Liu, Muguli Muhaxi, Ni Zheng, Fatemeh Sefidkon, Kejian Pang, Guangwen Shu*, Xinzhou Yang*. Ethyl acetate extract of Ferula ferulaeoides induces apoptosis in esophageal cancer through the mitochondrial apoptotic and PI3K/Akt pathways. Arabian Journal of Chemistry, 2023, 16: 105291. (中科院二區(qū), IF6.13)

19.    Wenqi Liu, Siwen Kang, Ni Zheng, Yerlan Bahetjan, Huijian Chen, Guangzhong Yang*, Xinzhou Yang*. A composition of ursolic acid derivatives from Ludwigia hyssopifolia induces apoptosis in throat cancer cells via the Akt/mTOR and mitochondrial signaling pathways and by modulating endoplasmic reticulum stress. Journal of Ethnopharmacology, 2023, 117351, https://doi.org/10.1016/j.jep.2023.117351. (中科院二區(qū)Top, IF5.40)

20.    Ting Zhang, Xiangluan Wan, Changfu Liu, Jing Luo, Dingrong Wan, Xinzhou Yang. A comparative UPLC-MS-based metabolomics approach for distinguishing four different cultivars of Qiai (Artemisia argyi Lévl. et Van. in Qichun). Arabian Journal of Chemistry, 2024, 17: 105452. https://doi.org/10.1016/j.arabjc.2023.105452. (中科院二區(qū)Top, IF6.13)

21.    Ting Zhang, Dingrong Wan, Yuanyuan Li, Sisi Wang, Xiuteng Zhou*, Fatemeh Sefidkon, Xinzhou Yang*. UPLC-MS analysis, quantification of compounds, and comparison of bioactivity of methanol extract and its fractions from Qiai (Artemisia argyi Lévl. et Van.). Molecules, 2023, 28, 2022. https://doi.org/10.3390/molecules28052022. (中科院二區(qū)Top, IF4.92)

22.    Haitao Cheng, Yanhong Yao, Huijian Chen, Ping Zhao, Xinyi Kang, Xiuteng Zhou*, Wenqi Liu, Xinzhou Yang*. Discovery of bicyclic polyprenylated acylphloroglucinols from Hypericum himalaicum with glucose transporter 4 translocation activity. Bioorganic Chemistry, 2022, 129, 106160.https://doi.org/10.1016/j.bioorg. (中科院一區(qū)Top, IF 5.27)

23.    Yerlan Bahetjan, Muguli Muhaxi, Kejian Pang, Murat Kizaibek, Hui Tang*, Sefidkon Fatemeh, Xinzhou Yang*. Chemistry, Bioactivity, and Prediction of Quality marker (Q-marker) of Ferula plants in China: A Review. Molecules, 2023, 28, 5191. https://doi.org/10.3390/molecules28135191. (中科院二區(qū)Top, IF4.93)

24.    Yan Hu*, Shangwen Zhang, Zhijie Wen, Hudie Fu, Jie Hu, Xuexin Ye, Li Kang, Xiaojun Li, Xinzhou Yang*. Oral delivery of curcumin via multi-bioresponsive polyvinyl alcohol and guar gum based double-membrane microgels for ulcerative colitis therapy. Int J Biol Macromol., 2022, 221: 806-820. doi: 10.1016/j.ijbiomac.2022.09.050. (中科院一區(qū)Top , IF 8.02)

25.    Chao Wang, Xinzhou Yang, George D. Mellick*, Yunjiang Feng*. Phlegmacaritones A and B, a Pair of Serratane-Related Triterpenoid Epimers with an Unprecedented Carbon Skeleton from Phlegmariurus carinatus. Journal of Natural Products, 2022, 85(4): 899–909. (中科院二區(qū) , IF 4.80)

26.    Ping Tang#, Xinzhou Yang#, Huijian Chen, Ting Zhang, Hui Tang*, Kejian Pang*. Anti-diabetic activity of extract from Morus nigra L. twigs in type 2 diabetic mice through activation of AMPK/PKC pathway. Journal of Functional Foods, 2022, 99, 105358. (二區(qū)Top, IF 5.22)

27.    Yu Peng, Tongxi Zhou, Xiaojun Li*, Xinzhou Yang*. Dehydrocostus lactone inhibits the proliferation of esophageal cancer cells in vivo and in vitro through ROS-mediated apoptosis and autophagy. Food and Chemical Toxicity, 2022, 2022, 170, 113453. https://doi.org/10.1016/j.fct.2022.113453.  (二區(qū)Top, IF 6.02)

28.    Yibing Lv#, Ping Zhao#, Kejian Pang, Yuanren Ma, Ji Hao, Huiqi Huang, Xinzhou Yang*. Antidiabetic Effect of a Flavonoid-Rich Extract From Sophora alopecuroides L. in HFD and STZ Induced Diabetic Mice through PKC/GLUT4 Pathway and Regulating PPARα and PPARγ expression. Journal of Ethnopharmacology, 2021, 268: 113654.

29.    Yun Huang#, Tongxi Zhou#, Huiqi Huang, Chaoqun Wu, Qinxiong Lin, Qiang Wang, Jinyan Zhang, Xinzhou Yang*, Kejian Pang*. Antidiabetic activity of a Flavonoid-Rich Extract from flowers of Wisteria sinensis in type 2 diabetic mice via activation of the IRS-1/PI3K/Akt/GLUT4 pathway. Journal of Functional Foods, 2021, 77: 104338.

30.    Chaoqun Wu, Huiqi Huang, Yuanren Ma, Tongxi Zhou, Yu Peng, Kejian Pang, Guangwen Shu*, Xinzhou Yang*. Anti-esophageal Cancer Effect of Corilagin Extracted from Phmllanthi Fructus via the Mitochondrial and Endoplasmic Reticulum Stress Pathways. Journal of Ethnopharmacology, 2021, 269: 113700.

31.    Yuanren Ma, Tongxi Zhou, Ping Zhao, Ho-Young Choi, Ji Hao, Huiqi Huang, Chaoqun Wu, Xinzhou Yang*, Kejian Pang*. New flavonoids from the roots of Sophora davidii (Franch.) Skeels and their glucose transporter 4 translocation activities. Bioorganic Chemistry, 2021, 106, 104500, https://doi.org/10.1016/j.bioorg.2020.104500.

32.    Shangwen Zhang, Li Kang, Sheng Hu, Jie Hu, Yanping Fu, Yan Hu*, Xinzhou Yang*. Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease. International Journal of Biological Macromolecules, 2021, 2021, 167: 1598-1612.

33.    Guanjun Song#, Yun Huang#, Mingrui Xiong, Di Tian, Qing-Hua Liu, Jinhua Shen, Ping Zhao*, Xinzhou Yang*. Aloperine relieves type 2 diabetes mellitus via enhancing GLUT4 expression and translocation. Frontiers in Pharmacology, 2021, 11: 561956.

34.    Chaoqun Wu#, Guangwen Shu#, Huiqi Huang, Kejian Pang, Xinzhou Yang*, Guangzhong Yang*. Methylgerambullin derived from Glycosmis pentaphylla mediates anti-hepatocellular carcinoma cancer effect by activating mitochondrial and endoplasmic reticulum stress signaling and inhibiting AKT and STAT3 pathways. Food and Chemical Toxicology, 2021, 149:112031.

35.    Huiqi Huang, Kangdi Li, Yu Peng, Tongxi Zhou, Xiandong Zhou, Jingtong Deng, Xinzhou Yang*, Guangzhong Yang*. A composition of bractatin and neobractatin from the fruits of Garcinia bracteata induces apoptosis in throat cancer through the endoplasmic reticulum stress, mitochondrial apoptotic and Akt pathways. Journal of Functional Foods, 2021, 84, 104585.

36.    Ji Hao#, Tongxi Zhou#, Yuanren Ma, Jingtong Deng, Haitao Cheng, Qiang Wang, Qinxiong Lin, Xinzhou Yang*, Hoyoung Choi*. New polyprenylated acylphloroglucinol derivatives and xanthones from Hypericum wilsonii. Frontiers in Chemistry, 2021, 9:717904.

37.    Feng Wei#, Xinzhou Yang#, Kejian Pang*, Hui Tang*. Traditional Uses, Chemistry, Pharmacology, Toxicology and Quality Control of Alhagi sparsifolia Shap.: A Review. Frontiers in Pharmacology, 2021, 12: 761811.

38.    Chang Liu, Hong Liu, Huiqi Huang, Ji Hao, Yibing Lv, Jinyan Zhang, Yuanren Ma, Chaoqun Wu, Rui Qin*, Xinzhou Yang*. Corilagin Induces Laryngeal Cancer Apoptosis by Activating Mitochondrial and Endoplasmic Reticulum Stress Signaling and Inhibiting AKT and STAT3 Pathways in vitro and in vivo. Journal of Functional Foods, 2020, 69: 103947.

39.    Yibing Lv, Wenjie Ren, Yirui Zhang, Yun Huang, Ji Hao, Kun Ma, Yuanren Ma, Xinzhou Yang*. Antidiabetic activity of a lipophilic extract from flowers of Wisteria sinensis by targeting the GLUT4 glucose transporter and regulating lipid metabolism disorders. Food & Nutrition Research, 2020, 64: 3589.

40.    Huiqi Huang, Chang Liu, Kejian Pang, Yibing Lv, Ji Hao, Chaoqun Wu, Yuanren Ma, Yu Peng, Xinzhou Yang*, Wei K. Zhang*. A biflavonoid-rich extract from Selaginella moellendorfii Hieron in vitro and in vivo mediates anticancer effect by inhibiting STAT3 and Akt/NF-κB signaling pathways to induce apoptosis in laryngeal carcinoma. Journal of Cellular and Molecular Medicine, 2020, 24(20): 11922–11935.

41.    Wanli Liang#, Yanzhang Wen#, Fang Huang, Qin Hu, Xiaojun Li, Wei Kevin Zhang*, Xinzhou Yang*. Chrysanthemum ethanol extract induced mitochondrial-dependent apoptosis of Kupffer cells in vivo and in vitro. Food & Function, 2020, 11(10): 8866-8877. 

42.    Ren Zhang, Ji Hao, Qingming Wu, Kaiwen Guo, Chao Wang, Wei Kevin Zhang, Wanxin Liu, Qiang Wang* and Xinzhou Yang*. Dehydrocostus lactone inhibits cell proliferation and induces apoptosis by PI3K/Akt/Bad and ERS signaling pathway in human laryngeal carcinoma. Journal of Cellular and Molecular Medicine, 2020, 24(11):6028-6042.

43.    Ping Zhao*, Jia Liu, Qian Ming, Di Tian, Jingwen He, Ziwei Yang, Jinhua Shen, Qing?Hua Liu, Xinzhou Yang*. Dandelion extract relaxes mouse airway smooth muscle by blocking VDLCC and NSCC. Cell & Bioscience, 2020, 10 (125): 1-12.

44.    Yibing Lv, Qian Ming, Ji Hao,Yun Huang, Hao Chen, Qiang Wang, Xinzhou Yang*, Ping Zhao*. Anti-diabetic activity of canophyllol from Cratoxylum cochinchinense (Lour.) Blume in type 2 diabetes mice via activation of AMP-activated kinase and regulation of PPARγ. Food & Function, 2019, 10: 964-977.

45.    Yibing Lv, Ji Hao, Chang Liu, Huiqi Huang, Yuanren Ma, Xinzhou Yang*,,Li Tang*. Anti-diabetic Activity of a Phenolic-Rich Extract from Hypericum attenuatum Choisy in KK-Ay Mice via Activation of AMPK/PI3K/Akt/GSK3β pathway and Regulation of GLUT4 and PPARγ. Journal of Functional Foods, 2019, 61: 103506.

46.    Md. Adnan, Md. Nazim Uddin Chy, A.T.M. Mostafa Kamal, James W. Barlow, Mohammad Omar Faruque, Xinzhou Yang*, Shaikh Bokhtear Uddin*. Evaluation of anti-nociceptive and anti-inflammatory activities of the methanol extract of Holigarna caustica (Dennst.) Oken leaves. Journal of Ethnopharmacology, 2019, 236: 401-411.

47.    Ping Zhao*,#, Di Tian#, Guanjun Song, Qian Ming, Jia Liu, Jinhua Shen, Qinghua Liu, Xinzhou Yang*. Neferine promotes GLUT4 expression and fusion with the plasma membrane to induce glucose uptake in L6 cells. Front. Pharmacol., 2019, 10: 999.

48.    Mohammad Omar Faruquea, Umme Ruman Ankhi, M. Kamaruzzaman, James W. Barlow, Bo Zhou, Ji Hao, Xinzhou Yang*, Xuebo Hu*. Chemical composition and antimicrobial activity of Congea tomentosa, an ethnomedicinal plant from Bangladesh. Industrial Crops and Products, 2019, 141, 111745.

49.     Hao Chen, Jingquan Yuan*, Ji Hao, Yanzhang Wen, Yibin Lv, Lu Chen, Xinzhou Yang*. α-Humulene induces hepatocellular carcinoma cell antiproliferation and apoptosis through inhibiting AKT signaling. Food and Chemical Toxicology, 2019, 134: 110830.

50.    Yun Huang, Ji Hao, Di Tian, Yanzhang Wen, Ping Zhao, Hao Chen, Yibing Lv, Xinzhou Yang*. Antidiabetic activity of a flavonoid-rich extract from Sophora davidi (Franch.) skeels in KK-Ay mice via activation of AMP-activated protein kinase. Frontiers in Pharmacology, 2018, 9:760.

51.    Guangwen Shu, Ji Hao, Wei Li, Lang Zhang, Yunhan Qiu, Xinzhou Yang*. Liensinine suppresses STAT3-dependent HK2 expression through elevating SHP-1 to induce apoptosis in hepatocellular carcinoma cells in vitro and in vivo. Journal of Functional Foods, 2018, 45: 288-297.

52.    Mingrui Xiong1, Yun Huang1, Yajing Liu, Mi Huang, Guanjun Song, Qian Ming, Xinhua Ma, Jie Yang, Shihao Deng, Yanzhang Wen, Jinhua Shen, Qing-Hua Liu, Ping Zhao*, Xinzhou Yang*. Antidiabetic activity of ergosterol from Pleurotus ostreatus in KK-Ay mice with spontaneous type 2 diabetes mellitus. Molecular Nutrition & Food Research, 2018, 62 (3). doi: 10.1002/mnfr.201700444.

53.    Sijian Zheng1, Shihao Deng1, Mi Huang, Ping Zhao, Yun Huang, Xinhua Ma, Yanzhang Wen, Qiang Wang*, Xinzhou Yang*. Anti-diabetic activity of polyphenol-rich extract from Phellinus igniarius in KK-Ay mice with spontaneous type 2 diabetes mellitus. Food & Function, 2018, 9: 614-623.

54.    Jie Yang1, Hao Chen1, Shihao Deng, Mi Huang, Xinhua Ma, Ping Song, Jingwen Du, Yun Huang, Yanzhang Wen, Yongshen Ren*, Xinzhou Yang*. Inhibitory effect of kurarinone on growth of human non-small cell lung cancer: an experimental study both in vitro and in vivo studies. Frontiers in Pharmacology, 2018, 9: 252.

55.    Hao Chen1, Bei Zhou1, Jie Yang, Xinhua Ma, Shihao Deng, Yun Huang, Yanzhang Wen, Jingquan Yuan*, Xinzhou Yang*. Essential oil derived from Eupatorium adenophorum Spreng. mediates anticancer effect by inhibiting STAT3 and AKT activation to induce apoptosis in hepatocellular carcinoma. Frontiers in Pharmacology, 2018,  9: 483..

56.    Xinzhou Yang1, Mi Huang1, Jie Yang, Jialin Wang, Sijian Zheng, Xinhua Ma, Jinyan Cai, Shihao Deng, Gunagwen Shu*, Guangzhong Yang*. Activity of isoliensinine in improving the symptoms of type 2 diabetic mice via activation of AMP-activated kinase and regulation of PPARγ. J. Agric. Food Chem., 2017, 65 (33): 7168-7178.

57.    Jialin Wang1, Mi Huang1, Jie Yang, Xinhua Ma, Sijian Zheng, Shihao Deng, Yun Huang, Yanzhang Wen, Xinzhou Yang*, Ping Zhao*. Anti-diabetic activity of stigmasterol from soybean oil by targeting GLUT4 glucose transporter. Food & Nutrition Research, 2017, 61 (1): 1364117.

58.    Li Chen1, Sijian Zheng1, Mi Huang1, Xinhua Ma, Jie Yang, Shihao Deng, Yun Huang, Yanzhang Wen, Xinzhou Yang*. β-Ecdysterone from Cyanotis arachnoidea exerts hypoglycemic effects through activating IRS-1/Akt/GLUT4 and IRS-1/Akt/GLUT2 signal pathways in KK-Ay mice. Journal of Functional Foods, 2017, 39: 123-132.

59.    Jie Yang1, Chan Xu1, Hao Chen, Mi Huang, Xinhua Ma, Shihao Deng, Yun Huang, Yanzhang Wen, Xinzhou Yang*, Ping Song*. In vitro and in vivo antitumor effects of the diterpene enriching extract from Taxodium ascendens through the mitochondrial-dependent apoptosis pathway. Biomedicine & Pharmacotherapy, 2017, 96: 1199-1208.

60.    Qi Zhou1, Xinzhou Yang1, Mingrui Xiong, Xiaolan Xu, Li Zhen, Weiwei Chen, Yan Wang, Jinhua Shen, Ping Zhao*, Qing-Hua Liu*. Chloroquine increases glucose uptake via enhancing GLUT4 translocation and fusion with the plasma membrane in L6 cells. Cell. Physiol. Biochem. 2016, 38: 2030-2040.

61.    Guangwen Shu, Lang Zhang, Shanqing Jiang, Zhuo Cheng, Guan Wang, Xu Huang, Xinzhou Yang*. Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction. Oncotarget, 2016, 7(26):40285-40296.

62.    Mi Huang, Shihao Deng, Qianqian Han, Ping Zhao, Qi Zhou, Sijian Zheng, Xinhua Ma, Chan Xu, Jing Yang, Xinzhou Yang*. Hypoglycemic activity and the potential mechanism of the flavonoid rich extract from Sophora tonkinensis Gagnep. in KK-Ay mice. Frontiers in Pharmacol., 2016, 7: 288.

63.    Mi Huang, Ping Zhao, Mingrui Xiong, Qi Zhou, Sijian Zheng, Xinhua Ma, Chan Xu, Jing Yang, Xinzhou Yang*, Tong-Cun Zhang*. Antidiabetic activity of perylenequinonoid-rich extract from Shiraia bambusicola in KK-Ay mice with spontaneous type 2 diabetes mellitus. J. Ethnopharmacol., 2016, 191: 71-81.

64.    Guangwen Shu, Ling Yue, Wenhao Zhao, Chan Xu, Jing Yang, Shaobing Wang, Xinzhou Yang*. Isoliensinine, a bioactive alkaloid derived from embryos of Nelumbo nucifera, induces hepatocellular carcinoma cell apoptosis through suppression of NF-κB signaling. J. Agric. Food Chem., 2015, 63 (40): 8793-8803.

65.    Xinzhou Yang#, Jing Yang#, Chan Xu, Mi Huang, Qi Zhou, Jingnan Lv, Xinhua Ma, Changqiang Ke, Yang Ye, Guangwen Shu*, Ping Zhao*. Antidiabetic effects of flavonoids from Sophora flavescens EtOAc extract in Type 2 diabetic KK-Ay mice. J.  Ethnopharmacol., 2015, 171: 161-170. .

66.    Guangwen Shu, Jing Yang, Chan Xu, Zhinnan Mei, Xinzhou Yang*. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicology and Applied Pharmacology, 2014, 281 (2):157-65.

67.    Xinzhou Yang, Rohan A. Davis, Malcolm S. Buchanan, Sandra Duffy, Vicky M. Avery, David Camp, Ronald J. Quinn*. Antimalaria bromotyrosine derivatives from the Australian marine sponge Hyattella sp. J. Nat. Prod., 2010, 73, 985-987.

68.    Li-Gen Lin#, Xin-Zhou Yang#, Chun-Ping Tang, Chang-Qiang Ke, Ji-Bao Zhang, Yang Ye*. Antibacterial stilbenoids from Stemona tuberosa. Phytochemistry, 2008, 69, 457-463.

著作

1.      《武漢南湖藥用植物圖鑒》,20181月,第一版,,化學工業(yè)出版社,,第一主編

2.      《壯醫(yī)藥》,,202112月,,湖北科技出版社,第一主編

3.      《中國毒性民族藥志》,,201511月,,第一版,科學出版社,,第一副主編

4.      《中國五峰特色常見藥用植物》,,20149月,第一版,,編委

5.        《湖北中藥志》,,編委

 

專利

1.        楊新洲, 黃蘊, 宋萍, 趙平, 田迪, 郝吉, 呂奕兵. 一種白刺花黃酮提取物及其制備方法和用途. ZL201810717809.4(已授權(quán))2021.08.13

2.        楊新洲. 用于治療喉癌的藥物組合物、其制備方法及其應用. ZL202010195158.4 (已授權(quán))2021.08.17

3.        宋萍, 楊新洲, 陳豪, 楊潔.一種治療癌癥的藥物組合物及其應用. ZL201710589075.1(已授權(quán))2018.6.26

4.        楊新洲, 黃密, 趙平, 黃蘊. 竹黃乙酸乙酯萃取物用于制備防治糖尿病藥物的用途. ZL201510473612.7(已授權(quán))2018.9.28

5.        楊新洲, 陳豪, 袁經(jīng)權(quán),楊潔. 一種治療癌癥的藥物組合物及其用途. ZL201710577162.5(已授權(quán))2018.7.27

6.        楊新洲, 黃密, 鄭思建, 趙平, 黃蘊. 一種治療糖尿病的藥物組合物及其制備方法和用途. ZL201710577168.2. (已授權(quán))2018.10.26

7.        楊新洲, 呂奕兵, 郝吉. 一種治療由代謝異常所致疾病的藥物組合物及其制備方法和應用. 專利申請?zhí)?/span> 201910521162.2.

8.        楊新洲, 呂奕兵, 黃蘊. 紫藤花總黃酮活性部位及其制備方法,、防治糖尿病的藥物組合物及應用. 專利申請?zhí)?/span> 201910548201.8.

9.        楊新洲, 黃密, 趙平, 黃蘊,,麻新華. 蓮心堿、異蓮心堿和甲基蓮心堿制備GLUT4活性促進劑中的用途.申請?zhí)?/span>201710017338.1.

10.    楊新洲, 趙平, 黃蘊, 田迪, 宋冠軍. 苦豆堿在制備治療糖尿病藥物中的應用以及苦豆堿的提取方法. 申請?zhí)?/span>201810835045.9

11.    Hamburger M, Hering S., Yang X.Z., Baburin I., et al. Int. Appl. No.:EP 09 159 117.2, Appl. Date: 29 April 2009.

12.    Ye Y., Lin G., Xu R.S., Ge F, Yang X.Z., et al. Int. Appl. No.:PCT/CN2008/001690, Pub. No.:WO/2009/046635.

學術(shù)交流

1.        2022924, 在線上參加了“世界中醫(yī)藥學會聯(lián)合會中藥化學專業(yè)委員會第十屆學術(shù)年會暨黑龍江中醫(yī)藥大學藥學院建院五十周年慶祝大會”會議,,作了“基于GLUT4靶點和民族藥物庫的抗糖尿病天然產(chǎn)物的發(fā)現(xiàn)研究”的報告,,與參會的專家學者進行了深入的交流.

2.        2019111520191117, 在浙江麗水參加了“2019年畬醫(yī)藥臨床應用學習班”,作了“基于民族藥物庫和活性導向的活性天然產(chǎn)物的發(fā)現(xiàn)”的報告,,與參會的專家學者進行了深入的交流.

3.        2019518, 在武漢參加了“第二屆 天然藥物(中藥,、民族藥)研究--南湖論壇”,作了“基于民族藥物庫的一些研究進展”的報告,,與參會的專家學者進行了深入的交流.

4.        2018127日至2018129, 在廣西都安參加了“2018年全國瑤醫(yī)藥學術(shù)交流會”會議,,作了“民族藥物的新藥研究”的報告,與參會專家學者進行了深入的交流.

5.        2018116日至2018118日,,在武漢參加了“2nd One-Belt One- Road International Conference on Traditional Medicine”國際會議,,與參會專家做了深入的交流.

6.        20181013日至20181015, 在海南海口參加了“全國民族醫(yī)藥學者論壇海南黎族醫(yī)藥專題”會議,,作了“基于民族藥物庫和活性導向的活性天然產(chǎn)物的發(fā)現(xiàn)”的報告,,與參會的專家學者進行了深入的交流.

7.        2018725日至2018730日在新疆伊犁參加了“民族醫(yī)藥科研能力提升培訓班暨中國民族醫(yī)藥學會科研分會常務理事會”,,與參會的專家學者進行了深入的交流.

8.        201864日至201668日,,在上海參加了“The 9th Plenary Meeting of ISO/TC 249”國際會議,,與參會專家做了深入的交流.

9.        2018420日至2018422日,在北京參加了“中國民族醫(yī)藥學會科研分會第三屆學術(shù)年會”,,與參會的專家學者進行了深入的交流.

10.    201765日至201768日,,在香港參加了“The 8th Plenary Meeting of ISO/TC 249 Traditional Chinese Medicine”國際會議,作了“Traditional Chinese Medicine ─ Ginkgo biloba L. Leaf”的大會報告.

作者:   責編:   審核:   上傳:

地址:中國-湖北-武漢 民族大道182號中南民族大學藥學院 郵編:430074
電話:027-67841196  Fax: 027-67841196
? 2016 中南民族大學藥學院