馮濤 （教授、博士生導(dǎo)師）
出生年月：1981.05
民 族：漢
學(xué)科專業(yè)：藥物化學(xué)
研究方向：天然藥物化學(xué)/真菌化學(xué)
電 話：15827269869
電子郵箱：[email protected]
一,、教育和工作簡(jiǎn)歷：
1. 2020/1-至今,，中南民族大學(xué),，藥學(xué)院,，教授,，博士生導(dǎo)師
2. 2019/7-2020/6,，德國(guó)萊布尼茲漢諾威大學(xué),，訪問(wèn)學(xué)者
3. 2015/7-2019/12，中南民族大學(xué),，藥學(xué)院，副教授,，碩士生導(dǎo)師
4. 2010/7-2015/6,，中國(guó)科學(xué)院昆明植物研究所，植物化學(xué)與西部植物資源持續(xù)利用國(guó)家重點(diǎn)實(shí)驗(yàn)室,，副研究員
5. 2005/9–2010/6,，中國(guó)科學(xué)院昆明植物研究所，碩博連讀,，藥物化學(xué),，博士
6. 2000/9–2004/7，西南大學(xué),，學(xué)士
二,、研究方向：
1. 藥用植物化學(xué)成分的結(jié)構(gòu)與功能
2. 真菌天然產(chǎn)物的結(jié)構(gòu)與功能。主要研究特色為真菌特有天然產(chǎn)物的結(jié)構(gòu)、功能及其生物合成,。
三,、主要榮譽(yù)、獲獎(jiǎng)和社會(huì)兼職：
國(guó)家民委中青年英才,；中國(guó)科學(xué)院盧嘉錫青年人才獎(jiǎng),；中南民族大學(xué)第七屆三育人標(biāo)兵；中國(guó)科學(xué)院院長(zhǎng)優(yōu)秀獎(jiǎng),；中國(guó)科學(xué)院青年創(chuàng)新促進(jìn)會(huì)會(huì)員,；分獲云南省自然科學(xué)獎(jiǎng)勵(lì)一、二等獎(jiǎng),；Natural Products and Bioprospecting期刊編委,；中國(guó)菌物學(xué)會(huì)菌物化學(xué)專業(yè)委員會(huì)副主任；湖北省藥學(xué)會(huì)藥化專委會(huì)委員
四,、學(xué)術(shù)研究：
從事藥用植物,、真菌天然產(chǎn)物及其功能研究。聚焦真菌特有天然產(chǎn)物的結(jié)構(gòu)及其功能,，尤其是真菌特有聚酮和萜類分子,，發(fā)現(xiàn)具有獨(dú)特結(jié)構(gòu)的抗炎活性分子“口蘑三萜”，發(fā)現(xiàn)具有顯著鎮(zhèn)痛活性的真菌特有二萜等,。獲得新的天然產(chǎn)物700余個(gè),，多個(gè)分子被評(píng)為研究熱點(diǎn)。主持國(guó)家自然科學(xué)基金,、省部級(jí)項(xiàng)目等科研基金13項(xiàng),，在Org Lett，J Org Chem,，J Nat Prod,，J Agri Food Chem等多種學(xué)術(shù)期刊以第一作者或通訊作者發(fā)表研究論文160余篇。
（一）主要科研基金：
1. 國(guó)家自然科學(xué)基金面上項(xiàng)目（2022）：真菌特有guanacastane型二萜結(jié)構(gòu)及其鎮(zhèn)痛作用研究（22277147）,，主持,。
2. 國(guó)家自然科學(xué)基金面上項(xiàng)目（2018）：“口蘑三萜”的挖掘及其抗炎作用研究（81872762），主持,。
3. 國(guó)家自然科學(xué)基金項(xiàng)目（2011）：四種有毒高等真菌毒性成分挖掘及毒性評(píng)價(jià)（81102346）,，主持。
4. 中央高?；究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)資金重點(diǎn)培育項(xiàng)目：口蘑屬三萜分子抗炎先導(dǎo)化合物的發(fā)現(xiàn),，主持。
（二）發(fā)表的主要研究論文：
1. Juan He, Jiao-Xian Du, Qian-Ru Zhao, Ya-Pei Liu, Yan-Long Yang,* Ji-Kai Liu,* Tao Feng*. Biochemical and genetic basis of guanacastane diterpene biosynthesis in basidiomycete fungi. Organic Letters 2023, 25, 5345-5349.
2. Jing Li, Wen-Xuan Wang, Zheng-Hui Li, Juan He, Rong Huang, Yong-Sheng Zheng, Lan-Qing Li, Xian Wang, Tao Feng*, Ji-Kai Liu*. Xylaridines C and D, unusual thiopyranodipyridine alkaloids from the fungus Xylaria longipes. Organic Letters 2019, 21, 6145?6148.
3. Jing Li, Wen-Xuan Wang, He-Ping Chen, Zheng-Hui Li, Juan He, Yong-Sheng Zheng, Huan Sun, Rong Huang, Qing-Xia Yuan, Xian Wang, Tao Feng*, Ji-Kai Liu*. (±)-Xylaridines A and B, highly conjugated alkaloids from the fungus Xylaria longipes. Organic Letters 2019, 21, 1511-1514.
4. Wen-Xuan Wang, Xin-Xiang Lei, Hong-Lian Ai, Xue Bai, Jing Li, Juan He, Zheng-Hui Li, Yong-Sheng Zheng, Tao Feng*, Ji-Kai Liu*. Cytochalasans from the endophytic fungus Xylaria cf. curta with resistance reversal activity against fluconazole-resistant Candida albicans. Organic Letters 2019, 21, 1108?1111.
5. Wen-Xuan Wang, Xin-Xiang Lei, Yan-Ling Yang, Zheng-Hui Li, Hong-Lian Ai, Jing Li,* Tao Feng,* Ji-Kai Liu,* Xylarichalasin A, a halogenated hexacyclic cytochalasan from the fungus Xylaria cf. curta. Organic Letters 2019, 21, 6957-6960.
6. Tao Feng, Kai-Ting Duan, Shi-Jun He, Bin Wu, Yong-Sheng Zheng, Hong-Lian Ai, Zheng-Hui Li, Juan He, Jian-Ping Zuo*, Ji-Kai Liu*. Ophiorrhines A and B, two immunosuppressive monoterpenoid indole alkaloids from Ophiorrhiza japonica. Organic Letters 2018, 20, 7926–7928
7. Wei Li, Juan He, Tao Feng*, Hui-Xiang Yang, Hong-Lian Ai, Zheng-Hui Li, Ji-Kai Liu*. Antroalbocin A, an antibacterial sesquiterpenoid from higher fungus Antrodiella albocinnamomea, Organic Letters 2018, 20, 8019–8021
8. Hui-Xiang Yang, Hong-Lian Ai, Tao Feng*, Wen-Xuan Wang, Bin Wu, Yong-Sheng Zheng, Huan Sun, Juan He, Zheng-Hui Li, Ji-Kai Liu*. Trichothecrotocins A–C, antiphytopathogenic agents from potato endophytic fungus Trichothecium crotocinigenum. Organic Letters 2018, 20, 8069–8072
9. Tao Feng, Xue-Mei Li, Jun He, Hong-Lian Ai, He-Ping Chen, Xiao-Nian Li, Zheng-Hui Li, and Ji-Kai Liu, Nicotabin A, a sesquiterpenoid derivative from Nicotiana tabacum. Organic Letters 2017, 19, 5201?5203.
10. Tao Feng, Yan Li, Ya-Ping Liu, Xiang-Hai Cai, Yuan-Yuan Wang, and Xiao-Dong Luo, Melotenine A, a cytotoxic monoterpenoid indole alkaloid from Melodinus tenuicaudatus, Organic Letters 2010, 12(5), 968-971.
11. Tao Feng, Xiang-Hai Cai, Yan Li, Yuan-Yuan Wang, Ya-Ping Liu, Ming-Jin Xie, and Xiao-Dong Luo, Melohenines A and B, two unprecedented alkaloids from Melodinus henryi, Organic Letters 2009, 11(21), 4834-4837.
12. Jin-Tao Ma, Xin-Yue Dong, Zheng-Hui Li, He Yan, Juan He,* Ji-Kai Liu,* Tao Feng*. Antibacterial metabolites from kiwi endophytic fungus Fusarium tricinctum, a potential biocontrol strain for kiwi canker disease. Journal of Agricultural and Food Chemistry 2023, 71, 7679-7688.
13. Hong-Lian Ai, Bao-Bao Shi, Wei Li, Juan He, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. Bipolarithizole A, an antifungal phenylthiazole-sativene merosesquiterpenoid from the potato endophytic fungus Bipolaris eleusines. Organic Chemistry Frontiers 2022, 9, 1814-1918.
14. Ying Huang, Shuai-Bing Zhang, He-Ping Chen, Zhen-Zhu Zhao, Zhong-Yu Zhou, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. New acetylenic acids and derivatives from the edible mushroom Craterellus lutescens (Cantharellaceae). Journal of Agricultural and Food Chemistry 2017, 65, 3835?3841.
15. He-Ping Chen, Zhen-Zhu Zhao, Zheng-Hui Li, Ying Huang, Shuai-Bing Zhang, Yang Tang, Jian-Neng Yao, Lin Chen, Masahiko Isaka, Tao Feng*, Ji-Kai Liu*, Anti-proliferative and anti-inflammatory lanostane triterpenoids from the Polish edible mushroom Macrolepiota procera. Journal of Agricultural and Food Chemistry 2018, 66, 3146-3154.
16. Tao Feng, Jin-Long Cai, Xue-Mei Li, Zhong-Yu Zhou, Zheng-Hui Li, and Ji-Kai Liu, Chemical constituents and their bioactivities of mushroom Phellinus rhabarbarinus. Journal of Agricultural and Food Chemistry 2016, 64, 1945?1949.
17. Tao Feng, Jia Su, Zhi-Hui Ding, Yong-Tang Zheng, Yan Li, Ying Leng, and Ji-Kai Liu, Chemical constituents and their bioactivities of “Tongling White Ginger” (Zingiber officinale), Journal of Agricultural and Food Chemistry 2011, 59, 11690-11695.
18. Shuai-bing Zhang, Ying Huang, Shi-jun He, He-ping Chen, Bin Wu, Shan-yong Li, Zhen-zhu Zhao, Zheng-hui Li, Xian Wang, Jian-ping Zuo, Tao Feng*, Ji-Kai Liu*. Heterocyclic compounds from the mushroom Albatrellus confluens and their inhibitions against lipopolysaccharides-induced B lymphocyte cell proliferation. Journal of Organic Chemistry 2018, 83, 10158?10165.（二區(qū)top）
19. Zhen-Zhu Zhao, He-Ping Chen, Bin Wu, Ling Zhang, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. Matsutakone and matsutoic acid, two (nor)steroids with unusual skeletons from the edible mushroom Tricholoma matsutake. Journal of Organic Chemistry 2017, 82, 7974?7979. （二區(qū)top）
20. Ming-Xuan Gao, Feng Wu, Si-Qiong Teng, He-Ping Chen, Zheng-Hui Li, Juan He,* Tao Feng,* Ji-Kai Liu*. Triquinane sesquiterpene glycosides from the basidiomycete Antrodiella zonata. Journal of Natural Products 2023, 86, 1736-1745.
21. Bao-bao Shi, Hong-Lian Ai, Kai-Ting Duan, Tao Feng*, Ji-Kai Liu*. Ophiorrhines F and G, key biogenetic intermediates of ophiorrhine alkaloids from Ophiorrhiza japonica and their immunosuppressant activities. Journal of Natural Products 2022, 85, 453-457.
22. Juan He, Rui Ma, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. Taccachatrones A?G, highly oxidized steroids from the rhizomes of Tacca chantrierii and their cytotoxicity assessment. Journal of Natural Products 2021, 84, 2265?2271.
23. Meng Wang, Jiao-Xian Du, Yang Hui-Xiang, Quan Dai, Ya-Pei Liu, Juan He, Yi Wang, Zheng-Hui Li, Tao Feng,* Ji-Kai Liu*. Sesquiterpenoids from cultures of the basidiomycetes Irpex lacteus. Journal of Natural Products 2020, 83, 1524-1531.
24. Ya-Pei Liu, Quan Dai, Wen-Xuan Wang, Juan He, Zheng-Hui Li, Tao Feng,* Ji-Kai Liu, Psathyrins: antibacterial diterpenoids from Psathyrella candolleana. Journal of Natural Products 2020, 83, 1725-1729.
25. Tao Feng, Xiao-Qing Gan, Yun-Li Zhao, Shuai-Bing Zhang, He-Ping Chen, Juan He, Yong-Sheng Zheng, Huan Sun, Rong Huang, Zheng-Hui Li*, Ji-Kai Liu*. Tricholopardins A and B, anti-inflammatory terpenoids from the fruiting bodies of Tricholoma pardinum. Journal of Natural Products 2019, 82, 45?50.
26. Tao Feng, Xiang-Hai Cai, Ya-Ping Liu, Yan Li, Yuan-Yuan Wang, Xiao-Dong Luo, Melodinines A–G, monoterpenoid indole alkaloids from Melodinus henryi, Journal of Natural Products 2010, 73, 22-26.
27. Tao Feng, Yan Li, Yuan-Yuan Wang, Xiang-Hai Cai, Ya-Ping Liu, Xiao-Dong Luo, Cytotoxic indole alkaloids from Melodinus tenuicaudatus,Journal of Natural Products 2010, 73, 1075-1079.
28. Tao Feng, Yan Li, Xiang-Hai Cai, Xun Gong, Ya-Ping Liu, Rong-Ting Zhang, Xiang-Yun Zhang, Qin-Gang Tan and Xiao-Dong Luo, Monoterpenoid indole alkaloids from Alstonia yunnanensis, Journal of Natural Products 2009, 72, 1836-1841.
29. Fa-Lei Zhang, Tao Feng*. Diterpenes specially produced by fungi: Structures, biological activities and biosynthesis (2010–2020). Journal of Fungi 2022, 8, 244.
30. Quan Dai, Fa‐Lei Zhang, Tao Feng*. Sesquiterpenoids specially produced by fungi: structures, biological activities, chemical and biosynthesis (2015–2020). Journal of Fungi 2021, 7, 1026.
（三）近年授權(quán)專利：
1. 馮濤,、劉吉開,、李正輝,，口蘑菌素甲及其制備方法與應(yīng)用、口蘑菌素乙及其制備方法與應(yīng)用, ZL201810010131.6
2. 馮濤,、劉吉開,、何雋、李正輝,、石晨,，口蘑三萜化合物、其制備方法,、提取物及其應(yīng)用, ZL202010980531.7
3. 馮濤,、劉吉開、楊會(huì)祥,，一種二萜類衍生物及其制備方法與鎮(zhèn)痛藥物,、小脆柄菇發(fā)酵得物及其乙酸乙酯萃取液，ZL202210290942.2
