出生年月：1990-01
民族：漢
職稱：副教授（碩士研究生導(dǎo)師）
學(xué)科專業(yè)：真菌天然產(chǎn)物化學(xué)與合成生物學(xué)
郵箱：[email protected]
教育經(jīng)歷
2014.09–2017.07：中國科學(xué)院昆明植物研究所，理學(xué)博士
2011.09–2014.07：中國科學(xué)院昆明植物研究所,，理學(xué)碩士
2007.09–2011.07：安徽醫(yī)科大學(xué),，理學(xué)學(xué)士
工作經(jīng)歷
2024.05–至今：中南民族大學(xué)藥學(xué)院,，副教授（碩士研究生導(dǎo)師）
2017.07–2024.04：中南民族大學(xué)藥學(xué)院,，講師（碩士研究生導(dǎo)師）
2019.11–2021.11：日本東京大學(xué)研究生院藥學(xué)系JSPS博士后,，合作導(dǎo)師：Ikuro Abe教授
學(xué)術(shù)兼職
Natural Products and Bioprospecting青年編委
個(gè)人主頁：
ORCID: https://orcid.org/0000-0003-0416-9535
ResearchGate: https://www.researchgate.net/profile/He_Ping_Chen2
主持的科研項(xiàng)目：
1. 國家自然科學(xué)基金面上項(xiàng)目,，82473810,，2025.01–2028.12，在研
2. 國家自然科學(xué)基金青年項(xiàng)目,，81903512,，2020.01–2022.12，已結(jié)題
3. 湖北省自然科學(xué)基金青年基金項(xiàng)目,，2019CFB379,，2019.09–2021.09，已結(jié)題
4. 中國科學(xué)院昆明植物研究所植物化學(xué)與西部植物資源持續(xù)利用國家重點(diǎn)實(shí)驗(yàn)室開放基金項(xiàng)目,，P2017-KF01,，2018-2020，已結(jié)題
5. 北京大學(xué)天然藥物及仿生藥物國家重點(diǎn)實(shí)驗(yàn)室開放基金項(xiàng)目,，K20180206,，2018.12–2019.06，已結(jié)題
6. 中央高?；究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)資金項(xiàng)目平臺專項(xiàng),，CPT22033，2022.04–2024.04
7. 科技部外國專家引進(jìn)計(jì)劃,，G2022185005L,，真菌活性天然產(chǎn)物生物合成與合成生物學(xué),，2022.1–2023.12，已結(jié)題
代表性研究成果：
2024
1. Qing-Yuan Wang#, He-Ping Chen#,*, Haobo Tao#, Xinyang Li, Qianru Zhao*, Ji-Kai Liu*. Penidaleodiolides A and B, Cage-like Polyketides with Neurontransmission-Regulating Activity from the Soil Fungus Penicillium daleae L3SO. Org. Lett. 2024, 26, 7632–7637.
2. Qing-Yuan Wang#, Yang Gao#, Jian-Neng Yao, Li Zhou*, He-Ping Chen*, Ji-Kai Liu*. Penisimplicins A and B, novel polyketide-peptide hybrid alkaloids from the fungus Penicillium simplicissimum JXCC5. Molecules 2024, 29(3), 613.
2023
3. Jing Fan#, Pai Liu#, Kuan Zhao*, He-Ping Chen*. Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus. Nat. Prod. Bioprospect. 2023, 13:46.
4. Qian-Qian Meng, Shun-Yao Tong, Xing-Rong Peng, Yu-Qing Zhao, Zheng-Hui Li, He-Ping Chen*, Ji-Kai Liu*. Nine New Pregnane Glycosides from the Cultivated Medicinal Plant Marsdenia tenacissima. Molecules 2023, 28, 2705. DOI:10.3390/molecules28062705.
2022
5. Lin Zhou#, He-Ping Chen#, Xinyang Li*, Ji-Kai Liu*. Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom Ganoderma australe. Pharmaceuticals 2022, 15, 1520.
6. Qing-Yuan Wang#, He-Ping Chen#, Kai-Yue Wu, Xinyang Li*, Ji-Kai Liu*. Antibacterial and β-amyloid precursor protein-cleaving enzyme 1 inhibitory polyketides from the fungus Aspergillus chevalieri. Front. Microbiol. 2022, 13, 1051281.
7. Xinyang Li#, He-Ping Chen#, Lin Zhou#, Jing Fan, Takayoshi Awakawa, Takahiro Mori, Richiro Ushimaru*, Ikuro Abe*, Ji-Kai Liu*. Cordycicadins A?D, Antifeedant Polyketides from the Entomopathogenic Fungus Cordyceps cicadae JXCH1. Org. Lett. 2022, 24 (47), 8627–8632.
8. Lin Zhou#, Subiy Akbar#, Meng-Xi Wang, He-Ping Chen*, Ji-Kai Liu*. Tetra-, penta-, and hexa-nor-lanostane triterpenes from the medicinal fungus Ganoderma australe. Nat. Prod. Bioprospect. 2022, 12, 32.
9. Lin-Lin Yuan, Bao-Bao Shi, Tao Feng, Rong Huang, Zheng-Hui Li, He-Ping Chen*, Ji-Kai Liu*. a-Glucosidase inhibitory phenylpropanoid-dihydrochalcone hybrids from the leaves of medicinal plant Malus hupehensis (Pamp.) Rehder. Phytochemistry 2022, 204, 113421.
10. Lin Zhou#, Li-Li Guo#, Masahiko Isaka, Zheng-Hui Li*, He-Ping Chen*. [20(22)E]-Lanostane Triterpenes from the Fungus Ganoderma australe. J. Fungi, 2022, 8, 503.
11. Takahiro Mori#*, Yu Nakashima#, Heping Chen#, Shotaro Hoshino, Takaaki Mitsuhashi, Ikuro Abe*. Structure-based redesign of Fe(II)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation. Chem. Commun., 2022, 58, 5510-5513.
12. Hui Tao#, Takahiro Mori#*, Heping Chen, Shuang Lyu, Akihito Nonoyama, Shoukou Lee, Ikuro Abe*. Molecular Insights into the unusually promiscuous and catalytically versatile Fe(II)/-ketoglutarate-dependent oxygenase SptF. Nat. Commun., 2022, 13, 95.
13. Shui-Lin Liu#, Lin Zhou#, He-Ping Chen*, Ji-Kai Liu*. Sesquiterpenes with diverse skeletons from histone deacetylase inhibitor modified cultures of the basidiomycete Cyathus stercoreus (Schwein.) De Toni HFG134. Phytochemistry, 2022, 195, 113048.
2021
14. Qing-Yuan Wang, He-Ping Chen*, Ji-Kai Liu*. Isopimarane Diterpenes from the Rice Fermentation of the Fungicolous Fungus Xylaria longipes HFG1018. Phytochem. Lett., 2021, 45, 100–104.
15. He-Ping Chen, Ikuro Abe*. Microbial Soluble Aromatic Prenyltransferases for Engineered Biosynthesis. Synth. Syst. Biotechnol., 2021, 6, 51–62.
16. Zhen-Zhu Zhao, Qi-Lu Zhao, Wei-Sheng Feng, Hai-Rong He, Meng Li, Gui-Min Xue, He-Ping Chen*, Ji-Kai Liu*. Absolute stereostructure assignments of ochracines F–L, chamigrane and cadinane sesquiterpenes from the basidiomycete Steccherinum ochraceum HFG119. RSC Adv., 2021, 11, 18693.
2020
17. He-Ping Chen, Zhen-Zhu Zhao, Gui-Guang Cheng, Kuan Zhao, Kai-Yue Han, Lin Zhou, Tao Feng, Zheng-Hui Li, Ji-Kai Liu*. Immunosuppressive nor-isopimarane diterpenes from cultures of the fungicolous fungus Xylaria longipes HFG1018. J. Nat. Prod. 2020, 83, 401–412.
18. He-Ping Chen, Jing Li, Zhen-Zhu Zhao, Xinyang Li, Shui-Lin Liu, Qing-Yuan Wang, Ji-Kai Liu*. Diterpenes with bicyclo[2.2.2]octane moieties from the fungicolous fungus Xylaria longipes HFG1018. Org. Biomol. Chem. 2020, 18, 2410–2415.
19. He-Ping Chen, Xu Ji, Zheng-Hui Li, Tao Feng, Ji-Kai Liu*. Irlactane and tremulane sesquiterpenes from the cultures of the medicinal fungus Irpex lacteus HFG1102. Nat. Prod. Bioprospect. 2020, 10, 89–100.
20. Zhen-Zhu Zhao, Xu-Bo Liang, Wei-Sheng Feng, Gui-Min Xue, Ying-Ying Si, He-Ping Chen*, Ji-Kai Liu*. Cyclic dipeptides with peroxy groups from the fruiting bodies of the edible mushroom Tricholoma matsutake. Tetrahedron Lett. 2020, 61, 151892.
21. Zhen-Zhu Zhao, Ji-Kai Liu, He-Ping Chen*. Microporotriol, a new cadinane-type sesquiterpenoid from the cultures of the wood-decay fungus Microporus affinis HFG829. Nat. Prod. Res. 2020, 34, 2194–2201.
2019
22. Yang Tang, Zhen-Zhu Zhao, Kun Hu, Tao Feng, Zheng-Hui Li, He-Ping Chen*, Ji-Kai Liu*. Irpexolidal represents a class of triterpenoid from the fruiting bodies of the medicinal fungus Irpex lacteus. J. Org. Chem. 2019, 84, 1845–1852.
23. Yang Tang, Zhen-Zhu Zhao, Tao Feng, Zheng-Hui Li, He-Ping Chen*, Ji-Kai Liu*. Triterpenes with unusual modifications from the fruiting bodies of the medicinal fungus Irpex lacteus. Phytochemistry 2019, 162, 21–28.
24. Zhen-Zhu Zhao, Kai-Yue Han, Zheng-Hui Li, Tao Feng, He-Ping Chen*, Ji-Kai Liu*. Cytotoxic ergosteroids from the fungus Stereum hirsutum. Phytochemistry Lett. 2019, 30, 143–149.
25. Zhen-Zhu Zhao, Xu-Bo Liang, Wei-Sheng Feng, Ya Wu, Yan-Le Zhi, Gui-Min Xue, He-Ping Chen*, Ji-Kai Liu*. Unusual constituents from the medicinal mushroom Ganoderma lingzhi. RSC Adv. 2019, 9, 36931–36939.
26. Zhen-Zhu Zhao, Wei-Sheng Feng, Xu-Bo Liang, Gui-Min Xue, Ying-Ying Si, He-Ping Chen*, Ji-Kai Liu*. Ochracines A-E, chamigrane-related norsesquiterpene derivatives from the basidiomycete Steccherinum ochraceum HFG119. Fitoterapia 2019, 139, 104362.
27. Kai-Yue Han, Xing Wu, Chenglin Jiang, Rong Huang, Zheng-Hui Li, Tao Feng, He-Ping Chen*, Ji-Kai Liu*. Three new compounds from the actinomycete Actinocorallia aurantiaca. Nat. Prod. Bioprospect. 2019, 9, 351–354.
28. Sheng-Xiang Yang, Wen-Ting Zhao, Heng-Ye Chen, Lei Zhang, Ting-Kai Liu, He-Ping Chen*, Jian Yang*, Xiao-Long Yang*. Aureonitols A and B, two new c13-polyketides from Chaetomium globosum, an Endophytic Fungus in Salvia miltiorrhiza. Chem. & Biodivers. 2019, 16, e1900364.
2018
29. He-Ping Chen, Zhen-Zhu Zhao, Zheng-Hui Li, Ying Huang, Shuai-Bing Zhang, Yang Tang, Jian-Neng Yao, Lin Chen, Masahiko Isaka, Tao Feng*. Ji-Kai Liu*. Antiproliferative and anti-inflammatory lanostane triterpenoids from the Polish edible mushroom Macrolepiota procera. J. Agric. Food Chem. 2018, 66, 3146–3154.
30. He-Ping Chen, Meng-Yuan Jiang, Zhen-Zhu Zhao, Tao Feng, Zheng-Hui Li, Ji-Kai Liu*. Vibralactone biogenesis-associated analogues from submerged cultures of the Fungus Boreostereum vibrans. Nat. Prod. Bioprospect. 2018, 8, 37–45.
31. He-Ping Chen, Zhen-Zhu Zhao, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. Seco-tremulane sesquiterpenoids from the cultures of the medicinal fungus Irpex lacteu HFG1102. Nat. Prod. Bioprospect. 2018, 8, 113–119.
32. Yang Tang, Zhen-Zhu Zhao, Jian-Neng Yao, Tao Feng, Zheng-Hui Li, He-Ping Chen*, Ji-Kai Liu*. Irpeksins A–E, 1,10-seco-eburicane-type triterpenoids from the medicinal fungus Irpex lacteus and Their Anti-NO Activity. J. Nat. Prod. 2018, 81, 2163–2168.
33. Yang Tang, Zhen-Zhu Zhao, Zheng-Hui Li, Tao Feng, He-Ping Chen*, Ji-Kai Liu*. Irpexoates A–D, four triterpenoids with malonyl modifications from the fruiting bodies of the medicinal fungus Irpex lacteus. Nat. Prod. Bioprospect. 2018, 8, 171–176.
2017
34. Zhen-Zhu Zhao#, He-Ping Chen#, Bin Wu, Ling Zhang, Zheng-Hui Li, Tao Feng*, Ji-Kai Liu*. Matsutakone and matsutoic acid, two (nor)steroids with unusual skeletons from the edible mushroom Tricholoma matsutake. J. Org. Chem. 2017, 82, 7974–7979 (Co-first author).
35. He-Ping Chen, Ji-Kai Liu*. Secondary Metabolites from Higher Fungi. Progress in the Chemistry of Organic Natural Products. Springer International Publishing AG 2017, Vol. 106, pp.1–201.
