博士，教授,，碩士生導(dǎo)師,。曾在美國西南醫(yī)學(xué)中心、斯坦福大學(xué)諾貝爾獎得主Thomas C. Südhof教授實驗室從事博士后研究,，長期從事囊泡轉(zhuǎn)運與釋放,，鈣離子調(diào)節(jié)神經(jīng)遞質(zhì)釋放機制的科學(xué)研究工作。在包括Science,，Neuron,，PNAS，EMBO Rep,，J Neurosci等國際著名期刊在內(nèi)的各類SCI收錄期刊中發(fā)表文章20余篇,。主持多項國家自然科學(xué)基金、湖北省自然科學(xué)基金,。先后入選國家民委中青年英才計劃及湖北省優(yōu)秀青年骨干人才計劃,。目前主要運用分子/生化，遺傳學(xué),，電生理和光學(xué)等手段,，在生理和病理情況下研究神經(jīng)系統(tǒng)細胞信號跨膜傳導(dǎo)的時空調(diào)節(jié)機制，研究重點包括神經(jīng)遞質(zhì)釋放分子機制,，神經(jīng)突觸形成與調(diào)節(jié)機理,，神經(jīng)網(wǎng)絡(luò)發(fā)育調(diào)控，藥物鎮(zhèn)痛機制等,。研究成果為診斷,、治療重大神經(jīng)性疾病提供生物學(xué)基礎(chǔ)。
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1.Xiaofei Yang*, Yea Jin Kaeser-Woo*, Zhiping P. Pang, Wei Xu, Thomas C. Südhof. Complexin Clamps Asynchronous Releaseby Blocking a Secondary Ca2+-Sensor via its Accessory a-Helix. Neuron. 2010 Dec 9:68,907-920. 2.Xiaofei Yang, Peng Cao, Thomas C. Südhof. Deconstructing Complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20777-82. 3.Xiaofei Yang#, Dongmei Hou, Wei Jiang, Chen Zhang#. Intercellular protein-protein interactions at synapses. Protein Cell.2014 Jun;5(6):420-44.(#共同通訊作者) 4.Wei Jiang, Rui Hua, Mengping Wei, Chenhong Li, Zilong Qiu, Xiaofei Yang#, Chen Zhang. An optimized method for high-titer lentivirus preparations without ultracentrifugation. Sci Rep. 2015 Sep 8;5:13875. doi: 10.1038/srep13875.(#共同通訊作者) 5.Xiaofei Yang#,，Jimin Pei,，Yea Jin Kaeser-Woo，Taulant Bacaj,，Nick V. Grishin,，Thomas C. Südhof#，Evolutionary Conservation of Complexins: From Choanoflagellates to Mice，EMBO Reports,，2015,，16（10）：1308-1317. (#共同通訊作者) 6.Jihong Gong; Ying Lai; Xiaohong Li; Mengxian Wang; Jeremy Leitz; Yachong Hu; Yunxiang Zhang; Ucheor B. Choi; Daniel Cipriano; Richard A. Pfuetzner; Thomas C. Südhof; XiaofeiYang# ; Axel T. Brunger#; Jiajie Diao#, C-terminal domain of mammalian complexin-1 localizes to highly curved membranes, Proc Natl Acad Sci U S A., 2016.11.22, 113(47): E7590~E7599(#共同通訊作者) 7.Shen Wang ; Ucheor B. Choi ; Jihong Gong ; Xiaoyu Yang; Yun Li; Austin L. Wang; Xiaofei Yang#; Axel T. Brunger#; Cong Ma#, Conformational Changes of Syntaxin Linker Region induced by Munc13s Ignite SNARE-Complex Assembly in Synaptic Exocytosis, The EMBO Journal, 2017.3.15, 36(6): 816~829(#共同通訊作者) 8. Wei Jiang; Mengping Wei; Mengna Liu; Yunlong Pan; Dong Cao; Xiaofei Yang#; Chen Zhang#, Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation, Journal of Neuroscience, 2017.10.11, 37(41): 9828~9843(#共同通訊作者) 9. Yi Yu, Su Chen, Xiaoqiang Mo, Jihong Gong, Chenhong Li, Xiaofei Yang#. Accessory and Central α-helices of Complexin Selectively Activate Ca2+ Triggering of Synaptic Exocytosis. Front Mol Neurosci. 2018 Feb 26;11:61. (#通訊作者) 10.Su Chen, Yi Rong, Mengxue Liu, Song Cheng, Xiangming Liu, Xiaohong Li, Yi Yu, Guangzhong Yang, Xiaofei Yang#. Analgesic Effects of Triterpenoid Saponins From Stauntonia chinensis via Selective Increase in Inhibitory Synaptic Response in Mouse Cortical Neurons. Front Pharmacol. 2018 Nov 12;9:1302.(#共同通訊作者) |
