出生年月：1965年9月
民族：漢
職稱(chēng)：教授(二級(jí))、博士生導(dǎo)師
學(xué)科專(zhuān)業(yè)：藥理學(xué)/藥物化學(xué)
研究方向：天然產(chǎn)物心血管藥理學(xué)與新藥研發(fā)
電子郵箱：[email protected]
工作經(jīng)歷
2015.8,，中南民族大學(xué)藥學(xué)院藥理學(xué)研究所，教授(二級(jí)),、博士生導(dǎo)師；
2010.4~2018.10,，中國(guó)科學(xué)院昆明植物研究所,，研究員(二級(jí))、博士生導(dǎo)師,；
1999.6~2010.4，深圳海王集團(tuán)技術(shù)中心,，資深研究員,；
1984.6~1993.8，安徽省無(wú)為縣太平初級(jí)中學(xué),，教師,。
學(xué)習(xí)經(jīng)歷
1996.6~1999.6，中山大學(xué)生命科學(xué)學(xué)院,，動(dòng)物學(xué)(天然產(chǎn)物藥學(xué)方向)博士,；
1993.9~1996.6，中山大學(xué)生命科學(xué)學(xué)院,，生理學(xué)(心血管藥理學(xué)方向)碩士,；
1988.9~1990.6，安徽教育學(xué)院生物系,，進(jìn)修,；
1981.9~1984.6，安徽省無(wú)為師范學(xué)校,，中師,。
學(xué)術(shù)與應(yīng)用研究：
從事天然產(chǎn)物心血管藥理學(xué)活性與機(jī)制研究。重點(diǎn)方向是具有心血管藥理活性并具有重復(fù)結(jié)構(gòu)單元的天然產(chǎn)物多糖的化學(xué)結(jié)構(gòu),、結(jié)構(gòu)修飾,、藥效活性、藥理機(jī)制及構(gòu)效關(guān)系研究,。
巖藻糖化糖胺聚糖(fucosylated glycosaminoglycan, FG)結(jié)構(gòu)研究方面,，基于“bottom up”策略,，通過(guò)建立糖苷鍵選擇性解聚技術(shù)及寡糖純化與波譜學(xué)結(jié)構(gòu)解析技術(shù)，闡明了一系列不同物種來(lái)源的天然FG的確切結(jié)構(gòu),；獲得一系列用于藥理學(xué)活性與機(jī)制研究的,、具有特殊端基結(jié)構(gòu)的純品FG寡糖及其結(jié)構(gòu)修飾產(chǎn)物。
系統(tǒng)研究了FG及其解聚產(chǎn)物,、純品寡糖的抗凝抗血栓活性及其藥理學(xué)機(jī)制特點(diǎn),，重點(diǎn)研究了FG寡糖選擇性抑制內(nèi)源性因子X(jué)酶(Tenase, Xase)構(gòu)效關(guān)系、必須結(jié)構(gòu),、酶學(xué)動(dòng)力學(xué)特點(diǎn)與機(jī)制,、靶蛋白相互作用的動(dòng)力學(xué)過(guò)程與機(jī)制。
基于天然FG結(jié)構(gòu)修飾,，研制選擇性抑制內(nèi)源性Xase的新靶點(diǎn)抗凝抗血栓新藥LFG-53(First In Class,，獲FDA和NMPA臨床許可)，系列專(zhuān)利獲得國(guó)內(nèi),、美,、日等國(guó)授權(quán)，已實(shí)現(xiàn)知識(shí)產(chǎn)權(quán)及關(guān)鍵技術(shù)的企業(yè)技術(shù)轉(zhuǎn)移,。
海王集團(tuán)國(guó)家級(jí)企業(yè)技術(shù)中心工作期間,，組建藥物研發(fā)實(shí)驗(yàn)研究平臺(tái)，主管創(chuàng)新藥物研發(fā),。其代表性工作包括：立項(xiàng)并研發(fā)中藥天然藥物1類(lèi)新藥虎杖苷注射液(臨床批件(現(xiàn)已取得FDA臨床許可)),、5類(lèi)中藥新藥艾心酮片(臨床批件)、中藥大品種改進(jìn)藥物鼻淵軟膠囊(上市許可)等,。
在PNAS,、JBC、Carbohydr Polym,、Thromb Haemost,、Pharmacol Res、Eur J Med Chem,、Thromb Res,、Int J Biol Macromol、Mar Drugs,、BBA,、Angew Chem、Chem Eur J等國(guó)內(nèi)外學(xué)術(shù)期刊上發(fā)表論文百余篇,；申請(qǐng)國(guó)內(nèi)及PCT發(fā)明專(zhuān)利70余件,，已獲中、美,、日,、澳,、等國(guó)授權(quán)的發(fā)明專(zhuān)利60余件。
先后主持國(guó)家,、科學(xué)院及省級(jí)課題二十余項(xiàng),，包括國(guó)家新藥重大專(zhuān)項(xiàng)項(xiàng)目、863課題及引導(dǎo)項(xiàng)目,、發(fā)改委重大專(zhuān)項(xiàng),、自然科學(xué)基金項(xiàng)目、科技部技術(shù)創(chuàng)新基金項(xiàng)目,、科學(xué)院創(chuàng)新藥物項(xiàng)目,、科學(xué)院天然產(chǎn)物應(yīng)用轉(zhuǎn)化項(xiàng)目、粵港關(guān)鍵領(lǐng)域重點(diǎn)突破項(xiàng)目,、深港創(chuàng)新圈項(xiàng)目,、廣東省教育部產(chǎn)學(xué)研結(jié)合項(xiàng)目、云南省應(yīng)用基礎(chǔ)研究計(jì)劃重點(diǎn)項(xiàng)目,、云南省重點(diǎn)新產(chǎn)品項(xiàng)目等,。
主持承擔(dān)的部分課題項(xiàng)目：
國(guó)家新藥重大專(zhuān)項(xiàng)：LFG-53新藥臨床前研究(2017~2020)
國(guó)家發(fā)改委企業(yè)技術(shù)中心重大項(xiàng)目：①天然藥物創(chuàng)新能力建設(shè)(2008~2012)；
②創(chuàng)新海洋藥物研究開(kāi)發(fā)中心建設(shè)(2004~2008)
863課題：①牡蠣生物活性成分的提取及應(yīng)用研究(1999 ~2001),；
②中藥1類(lèi)新藥虎杖苷注射液(2005~2008)
自然基金面上項(xiàng)目：①P-選擇素抑制劑發(fā)現(xiàn)及其抗血栓活性研究(2021~2025)
②FG寡糖抑制Xase藥理機(jī)制(2017~2021),；
②FGAG純化結(jié)構(gòu)序列及其對(duì)血栓形成與止血功能的影響(2013~2017)
科技部科技型中小企業(yè)技術(shù)創(chuàng)新基金：降血脂藥蔗烷醇膠囊研制(2008~2010)；
科學(xué)院技術(shù)百人項(xiàng)目：天然產(chǎn)物成藥性研究技術(shù)平臺(tái)建設(shè)(2011~2013),；
科學(xué)院創(chuàng)新藥物研究院新藥項(xiàng)目：新靶點(diǎn)抗血栓藥物L(fēng)FG研究(2015~2018)；
科學(xué)院天然產(chǎn)物應(yīng)用轉(zhuǎn)化項(xiàng)目：P-選擇素抑制劑發(fā)現(xiàn)與轉(zhuǎn)化(2016~2018)
科學(xué)院自主部署項(xiàng)目：①活性天然多糖藥代,、安全性與應(yīng)用轉(zhuǎn)化(2015~2019),；
②基于天然產(chǎn)物及其片段的創(chuàng)新藥物研發(fā)能力建設(shè)(2010 ~ 2013)
云南省高端人才項(xiàng)目：基于天然產(chǎn)物及其結(jié)構(gòu)片段的創(chuàng)新藥物研發(fā)(2010~ 2016)
云南省基礎(chǔ)研究計(jì)劃重點(diǎn)項(xiàng)目：①LFG組分及其抗凝抗血栓活性(2016~2019)；
②抑制因子X(jué)酶的FG衍生物的構(gòu)效關(guān)系及應(yīng)用價(jià)值評(píng)價(jià)(2013~2016)
廣東省教育部產(chǎn)學(xué)研結(jié)合項(xiàng)目：虎杖苷注射液治療腦卒中適應(yīng)癥研究(2009~2011)
云南省科技計(jì)劃項(xiàng)目：抗艾新藥注射用DT-8臨床前預(yù)研究(2012~2015)
云南省創(chuàng)新團(tuán)隊(duì)項(xiàng)目：活性天然產(chǎn)物發(fā)現(xiàn)與生物合成(2017~2020年)
粵港關(guān)鍵領(lǐng)域重點(diǎn)突破項(xiàng)目：中藥1類(lèi)新藥虎杖苷注射液(2006 ~ 2009年)
深港創(chuàng)新圈計(jì)劃項(xiàng)目：中藥一類(lèi)創(chuàng)新藥物虎杖苷注射液(2006 ~ 2009年)
獲獎(jiǎng)與榮譽(yù)
2008年,，入選“改革開(kāi)放三十年廣東省醫(yī)藥行業(yè)杰出科技人才”
2010年,，入選“云南省引進(jìn)高端人才計(jì)劃”；
2011年,，入選中國(guó)科學(xué)院百人計(jì)劃(技術(shù)百人)
2015年,，F(xiàn).Xase抑制劑學(xué)術(shù)研究入選昆明植物研究所年度“十大進(jìn)展”；
2016年,，LFG新藥技術(shù)轉(zhuǎn)移入選昆明植物研究所年度“十大進(jìn)展(第一位)”,；
2017年，入選云南省政府“享受政府特殊津貼人員”
2024年,，獲2023年度云南省科學(xué)技術(shù)獎(jiǎng)(技術(shù)發(fā)明獎(jiǎng))一等獎(jiǎng)（第一完成人）
近年發(fā)表的部分學(xué)術(shù)論文：
Cui LG, Sun HF, Shang XL, Wen J, Li PF, Yang ST, Chen LX, Huang XY, Li HY, Yin RH*, and Zhao JH. Purification and structural analyses of sulfated polysaccharides from low-value sea cucumberStichopus nasoand anticoagulant activities of its oligosaccharides.Marine Drugs. 2024; 22: 265.
Ma Y, Zuo ZC, Zheng WQ, Yin RH, Wu XW, Ma YJ, Ji MC, Ma WW, Li X*, Xiao WL**, Gao N***, Zhao JH. Structural characterization of a distinct fucan sulfate fromPattalus mollisthrough an oligosaccharide mapping approach.Carbohyd Res., 2024, 536:109052.
Chen R, Wang WL, Yin RH, Pan Y, Xu C, Gao N*, Luo XD*, and Zhao JH. Structural characterization and anticoagulant activities of a keratan sulfate-like polysaccharide from the sea cucumberHolothuria fuscopunctata.Mar Drugs. 2023, 21: 632.
Lan D, Zhang JL, Shang XL, Yu LJ, Xu C, Wang P, Cui LG, Cheng NQ, Sun HF, Ran JN, Sha L, Yin RH,Gao N*,Zhao JH*. Branch distribution pattern and anticoagulant activity of a fucosylated chondroitin sulfate fromPhyllophorella kohkutiensis.Carbohyd Polym. 2023, 321:121304.
Ruzemaimaiti D#, Sun HF#, Zhang JL, Xu C, Chen LX, Yin RH*, Zhao JH*. Oligomer-guided recognition of two fucan sulfate fromBohadschia argusand inhibition of P-selectin binding to its ligand.Carbohyd Polym. 2023, 317:121080.
Sun HF, Yang SS, Li PF, Shang XL, Wang P, Zhang JL, Yuan L, Yin RH, Gao N*, Zhao JH*. Comparative assessment of APTT reagents for evaluating anticoagulant sensitivity of fucosylated glycosaminoglycans (FGs) derived from sea cucumbers.Mar Drugs. 2023, 21: 568.
Zuo ZC, He ZC, Ma Y, Xu C, Tao XL, Ning ZM, Gao L, Rehemiding A,Gao N*,Zhao JH*. Structure characterization of a highly branched galactan from the slugVaginulus alteand its utilization by human gut microbiota.Int J Biol Macromol. 2023, 236: 123935.
Li SJ, Wang WL, Lin LS, Yang L, Cai Y, Yang XZ, Zhang TC, Xiao C, Yan H, Gao N*,Zhao JH*. Oligosaccharide blocks PAR1 (Proteinase Activated Receptor 1)-PAR4–mediated platelet activation by binding to thrombin exosite II and impairs thrombosis.Arterioscler, Thromb, Vasc Biol.2023, 43:253-266.
Xia F#, Lin LS#, Ye YS#, Yang L, Zhao JH*, Xu G*. 11,12-seco-Abietane-type diterpene lactones with potential antiplatelet activity fromSalvia prattii.Bioorg Chem.2023, 140:106834.
Dai MY, Peng W, Lin LS, Wu, ZXE, Zhang T, Zhao Q, Cheng Y, Lin QX, Zhang BB, Liu AM, Rao QR, Huang JF, Zhao JH*, Gonzalez FJ*, Li F*. Celastrol as an intestinal FXR inhibitor trigger tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced byTripterygium wilfordii.Phytomedicine.2023, 121: 155054.
Wang WL#, Mao H#, Li SJ, Zhang LL, Yang L, Yin RH*, Zhao JH*. Branched chondroitin sulfate oligosaccharides derived from the sea cucumberAcaudina molpadioidesstimulate neurite outgrowth.Mar Drugs. 2022, 20: 653.
Tao XL, Wang WL, Shi X, Lan D, Mao H, Ning ZM, Gao L, Zuo ZC, Xu C, Yang ZQ, Wang Y, Zuo ZL, Gao N*, Zhao JH*. Peroxidative depolymerization of fucosylated glycosaminoglycan: Bond-cleavage pattern and activities of oligosaccharides.Carbohyd Polym. 2022, 295:119855.
Yin RH, Pan Y, Cai Y, Yang F, Gao N, Ruzemaimaiti D, Zhao JH*. Re-understanding of structure and anticoagulation: Fucosylated chondroitin sulfate from sea cucumberLudwigothurea grisea.Carbohyd Polym.2022, 294: 119826.
Li XM, Sun HF, Ning ZM, Yang WJ, Cai Y, Yin RH*, Zhao JH*. Mild acid hydrolysis on Fucan sulfate fromStichopus herrmanni: Structures, depolymerization mechanism and anticoagulant activity.Food Chem. 2022, 395: 133559.
Liu XX, Ning ZM, Zuo ZC, Wang P, Yin RH, Gao N*, Wu B, Zhao JH. The glycosidic bond cleavage and desulfation investigation of fucosylated glycosaminoglycan during mild acid hydrolysis through structural analysis of the resulting oligosaccharides.Carbohyd Res. 2022, 511: 108493.
Gao L, Xu C, Tao XL, Zuo ZC, Ning ZM, Wang LH, Gao N*, Zhao JH*. Structure elucidation of fucan sulfate from sea cucumberHolothuria fuscopunctatathrough a bottom-up strategy and the antioxidant activity analysis.Int J Mol Sci. 2022, 23: 4488.
Ning ZM, Wang P, Zuo ZC, Tao XL, Gao L, Xu C, Wang ZY, Wu B*, Gao N*, Zhao JH. A fucan sulfate with pentasaccharide repeating units from the sea cucumberHolothuria floridanaand its anticoagulant activity.Mar Drugs. 2022, 20: 377.
Li XM, Li SN, Liu J, Lin LS, Sun HF, Yang WJ, Cai Y, Gao N, Zhou LT, Qin HB*, Yin RH*, Zhao JH*. A regular fucan sulfate fromStichopus herrmanniand its peroxide depolymerization: Structure and anticoagulant activity.Carbohyd Polym.2021, 256: 117513.
Li SN, Zhong W, Pan Y, Lin LS, Cai Y, Mao H, Zhang TC, Li SJ, Chen R, Zhou LT, Wang WL, Cui QH*, Yin RH*, Huang SX*, Zhao JH*. Structural characterization and anticoagulant analysis of the novel branched fucosylated glycosaminoglycan from sea cucumberHolothuria nobilis.Carbohyd Polym.2021, 269: 118290.
Zhou LT, Yin RH, Gao N, Sun HF, Chen DY, Cai Y, Ren L, Yang L, Zuo ZL*, Zhang HB*, Zhao JH*. Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis.Pharmacol Res. 2021, 166: 105527.
Chen R, Yin RH, Li SN, Pan Y, Mao H, Cai Y, Lin LS, Wang WL, Zhang TC, Zhou LT, Gao N*, Luo XD*, Zhao JH*. Structural characterization of oligosaccharides from free radical depolymerized fucosylated glycosaminoglycan and suggested mechanism of depolymerization.Carbohyd Polym.2021, 270: 118368.
Yin RH, Zhou LT, Gao N, Lin LS, Sun HF, Chen DY, Cai Y, Zuo ZL, Hu KF, Huang SX*, Liu JK*, Zhao JH*. Unveiling the disaccharide-branched glycosaminoglycan and anticoagulant potential of its derivatives.Biomacromolecules. 2021, 22(3): 1244-55.
Ma Y, Gao N, Zuo ZC, Li SN, Zheng WQ, Shi X, Liu QP, Ma T, Yin RH*, Li X*, Zhao JH*. Five distinct fucan sulfates from sea cucumberPattalus mollis: Purification, structural characterization and anticoagulant activities.Int J Biol Macromol. 2021, 186: 535.
Shi X#, Guan RW#, Zhou LT, Zuo ZC, Tao XL, Wang P, Zhou YR, Yin RH, Zhao LY*, Gao N*, Zhao JH. Structural characterization and heparanase inhibitory activity of fucosylated glycosaminoglycan fromHolothuria floridana.Mar Drugs. 2021, 19(3): 162.
Liu S#, Zhang TC#, Sun HF, Lin LS, Gao N, Wang WL, Li SJ, Zhao JH *. Pharmacokinetics and pharmacodynamics of a depolymerized glycosaminoglycan fromHolothuria fuscopunctata, a Novel Anticoagulant Candidate, in rats by bioanalytical methods.Mar Drugs.2021, 19: 212.
Lin LS, Li SJ, Gao N, Wang WL, Zhang TC, Yang L, Yang XZ, Luo D, Ji X*, Zhao JH*. The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants.Mar Drugs. 2021, 19(9): 487-499.
Lin LS, Yang L, Chen J, Zhou LT, Li SJ, Gao N, Zhao JH*. High-molecular-weight fucosylated glycosaminoglycan induces human platelet aggregation depending on αIIbβ3 and platelet secretion.Platelets. 2021, 32(7): 975.
Mao H#, Cai Y#, Li SN, Sun HF, Lin LS, Pan Y, Yang WJ, He ZC, Chen R, Zhou LT, Wang WL, Yin RH*, Zhao JH*. A new fucosylated glycosaminoglycan containing disaccharide branches fromAcaudina molpadioides: Unusual structure and anti-intrinsic tenase activity.Carbohyd Polym. 2020, 245: 116503-12.
Yang WJ#, Chen DY#, He ZC, Zhou LT, Cai Y, Mao H, Gao N*, Zuo ZL*, Yin RH*, Zhao JH. NMR characterization and anticoagulant activity of the oligosaccharides from the fucosylated glycosaminoglycan isolated fromHolothuria coluber.Carbohyd Polym. 2020, 233: 115844-52.
Lin LS, Zhao LY, Gao N, Yin RH, Li SJ, Sun HF, Zhou LT, Zhao GL, Purcelle SW, Zhao JH*. From multi-target anticoagulants to DOACs, and intrinsic coagulation factor inhibitors.Blood Reviews. 2020, 39: 100615.
Gao N, Chen R, Mou RR, Xiang JY, Zhou K, Li Z, Zhao JH*. Purification, structural characterization and anticoagulant activities of four sulfated polysaccharides from sea cucumberHolothuria fuscopunctata.Int J Biol Macromol. 2020, 164: 3421–3428.
Sun HF#, Gao N#, Ren L, Liu S, Lin LS, Zheng WQ, Zhou LT, Yin RH, Zhao JH*. The components and activities analysis of a novel anticoagulant candidate dHG-5.Eur J Med Chem. 2020, 207:112796-801.
Zhou LT#, Gao N#, Sun HF, Xiao C, Yang L, Lin LS, Yin GH, Li Z, Zhang HB*, Ji X*, Zhao JH*. Effects of native fucosylated glycosaminoglycan, its depolymerized derivatives on intrinsic factor Xase, coagulation, thrombosis, and hemorrhagic risk.Thromb Haemost. 2020, 120(4):607-619.
Liu XX, Zhang ZX, Mao H, Wang P, Zuo ZC, Gao L, Shi X, Yin RH, Gao N*, Zhao JH*. Characterization of the hydrolysis kinetics of fucosylated glycosaminoglycan in mild acid and structure of the resulting oligosaccharides.Mar Drugs. 2020, 18: 286-302.
Luo D, Xu JP, Chen XJ, Zhu X, Liu S, Li J, Xu XT, Ma X*, Zhao JH*, Ji X*. EGCG attenuates salt-induced hypertension and renal injury in Dahl salt-sensitive rats.Sci Rep.2020, 10: 4783-93.
Cai Y#, Yang WJ#, Li XM, Zhou LT, Wang ZJ, Lin LS, Chen DY, Zhao LY, Li ZK, Liu SB, Yin RH*, Zuo ZL*, Gao N*, Zhao JH. Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments.Carbohyd Polym. 2019, 224:115146.
He ZC, Zhou LT, Lin LS, Yin RH*, Zhao JH*. Structure and heparanase inhibitory activity of a new glycosaminoglycan from the slugLimacus ?avus.Carbohyd Polym, 2019, 220:176–184.
Yang WJ#, Cai Y#, Yin RH, Lin LS, Li ZK*, Wu MY*, Zhao JH*. Structural analysis and anticoagulant activities of two sulfated polysaccharides from the sea cucumberHolothuria coluber.Int J Biol Macromol. 2018, 115: 1055-1062.
Xiao C, Zhao LY, Gao N, Wu MY, Zhao JH*. Nonasaccharide inhibits intrinsic factor Xase complex by binding to factor IXa and disrupting factor IXa-Factor VIIIa interactions.Thromb Haemost. 2019, 19: 705–715.
Luo D, Chen X, Zhu X, Liu S, Li J, Xu J, Zhao JH*, Ji X*. Pu-Erh tea relaxes the thoracic aorta of rats by reducing intracellular calcium.Front Pharmacol. 2019, 10:1-13.
Zheng WQ, Zhou LT, Lin LS, Cai Y, Sun HF, Zhao LY, Gao N, Yin RH*, Zhao JH*. Physicochemical characteristics and anticoagulant activities of the polysaccharides from sea cucumberPattalus mollis.Mar Drugs. 2019, 17(4): 198.
Guan RW, Peng Y, Zhou LT, Zheng WQ, Liu XX, Wang P, Yuan QX, Gao N, Zhao LY*, Zhao JH*. Precise structure and anticoagulant activity of fucosylated glycosaminoglycan fromApostichopus japonicus: Analysis of its depolymerized fragments.Mar Drugs. 2019, 17(4): 195.
Lin LS, Xu L, Xiao C, Zhou LT, Gao N, Wu MY, Zhao JH*. Plasma contact activation by a fucosylated chondroitin sulfate and its structure–activity relationship study.Glycobiology. 2018, 8(10): 754.
He HQ, Chen D, Li XM, Li CJ, Zhao JH *, Qin HB *. Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate.Org Biomol Chem.2019, 17: 2877.
Yin RH, Zhou LT, Gao N, Li Z, Zhao LY, Shang FN, Wu MY*, Zhao JH*. Oligosaccharides from depolymerized fucosylated glycosaminoglycan: Structures and minimum size for intrinsic factor Xase complex inhibition.J Biol Chem. 2018, 293(36): 14089.
Shang FN#, Mou RR#, Zhang ZD#, Gao N, Lin LS, Li ZK, Wu MY*, Zhao JH*. Structural analysis and anticoagulant activities of three highly regular fucan sulfates as novel intrinsic factor Xase inhibitors.Carbohyd Polym.2018, 195: 257-266.
Zhang X, Liu H, Lin L, Yao W, Zhao JH, Wu MY*, Li ZJ*. Synthesis of fucosylated chondroitin sulfate nonasaccharide as a novel anticoagulant targeting intrinsic factor Xase complex.Angew Chem Int Ed.2018, 57(39): 12880.
Zhao LY, Qin YJ, Guan RW, Zheng WQ, Liu JK,Zhao JH*. Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions.Carbohyd Polym.2018, 186: 217-225.
Liu J, Zhou LT, He ZC, Gao N, Shang FN, Xu JP, Li Z, Yang ZM, Wu MY*, Zhao JH*. Structural analysis and biological activity of a highly regular glycosaminoglycan fromAchatina fulica. Carbohyd Polym.2018, 181: 433-441.
Xu L#, Gao N#, Xiao C, Lin LS, Purcell SW, Wu MY*, Zhao JH*. Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition.Eur J Med Chem. 2018, 154:133-143.
Shang FN#, Gao N#, Yin RH, Lin LS, Xiao C, Zhou LT, Li Z, Purcell SW, Wu MY*, Zhao JH*. Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors.Eur J Med Chem.2018, 148: 423.
Zhang X, Yao W, Xu XJ, Sun HF, Zhao JH, Meng XB, Wu MY, Li ZJ*. Synthesis of fucosylated chondroitin sulfate glycoclusters: a robust route to new anticoagulant agents.Chem.-Eur J.2018, 24(7): 1694-1700.
Qin YJ, Yuan QX, Zhang YX, Li JL, Zhu XJ, Zhao LL, Wen J, Liu JK, Zhao LY,* Zhao JH*. Enzyme-assisted extraction optimization, characterization and antioxidant activity of polysaccharides from sea cucumberPhyllophorus proteus. Molecules.2018, 23: 590.
Cai Y, Yang WJ, Yin RH, Zhou LT, Li ZK, Wu MY*, Zhao JH*. An anticoagulant fucan sulfate with hexasaccharide repeating units from the sea cucumberHolothuria albiventer. Carbohyd Res. 2018, 464: 12.
Li XM, Luo L, Cai Y, Yang WJ, Lin LS, Li Z, Gao N, Purcell SW, Wu MY*, Zhao JH*. Structural elucidation and biological activity of a highly regular fucosylated glycosaminoglycan from the edible sea cucumberStichopus herrmanni.J Agric Food Chem. 2017, 65(42): 9315-9323.
Xiao C, Lian W, Zhou LT, GaoN, Xu L, Chen J, Wu MY*, Peng WL*, Zhao JH*. Interactions between depolymerized fucosylated glycosaminoglycan and coagulation proteases or inhibitors,Thromb Res. 2016, 146: 59-68.
Zhao LY#, Wu MY#, Xiao C, Yang L, Zhou LT, Gao N, Li Z, Chen J, Chen JC, Liu JK*, Qin HB*, Zhao JH*. Discovery of an intrinsic tenase inhibitor, pure nonasaccharide from fucosylated glycosamino-glycan.PNAS. 2015, 112: 8284-8289.
Gao N#, Lu F#, Xiao C, Yang L, Chen J, Zhou K, Wen DD, Li Z, Wu MY, Jiang JM, Liu GM*, Zhao JH*. β-Eliminative depolymerization of the fucosylated chondroitin sulfate and anticoagulant activities of resulting fragments.Carbohyd Polym. 2015, 127(3): 427–437;
Wu MY#, Wen DD#, Gao N, Xiao C, Yang L, Xu L, Lian W, Peng WL, Jiang JM*, Zhao JH*, Anticoagulant and antithrombotic evaluation of native fucosylated chondroitin sulfates and their derivatives as selective inhibitors of intrinsic factor Xase.Eur J Med Chem.2015, 92: 257-269
Wu MY, Xu L, Zhao LY, Xiao C, Gao N, Luo L, Yang L, Li Z, Chen LY,* Zhao JH*. Structural analysis and anticoagulant activities of the novel sulfated fucan possessing a regular well-defined repeating unit from sea cucumber.Mar Drugs.2015, 13: 2063-2084
Lian W, Huang N, Li Z, Zheng YT*, Peng WL*, Zhao JH*. Anti-HIV-1 activity and structure-activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope.Biochim Biophys Acta. 2013, 1830: 4681-4691.
Zhao LY#, Lai SS#, Huang R, Wu MY, Gao N, Xu L, Qin HB*, Peng WL*, Zhao JH. Structure and anticoagulant activity of fucosylated glycosaminoglycan degraded by deaminative cleavage.Carbohyd Polym.2013, 98(2): 1514-1523.
Luo L, Wu MY, Xu L, Lian W, Xiang JY, Lu F, Gao N, Zhao JH*. Comparison of physicochemical characteristics and anticoagulant activities of polysaccharides from three sea cucumbers.Mar Drugs. 2013, 11: 399-417.
Huang N, Wu MY, Zheng CB, Zhu L, Zhao JH*, Zheng YT*. The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry.Carbohyd Res. 2013, 380: 64-69.
近年獲得授權(quán)的發(fā)明專(zhuān)利
Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof.US 9896517b2[美國(guó)授權(quán)2018-02-20]
Zhao JH, Liu JK, Wu MY, Gao N, Lu F, Li Z. Low-molecular-weight-glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof.特許6293862[日本授權(quán)2018-02-23]
Zhao JH, Wu MY, Gao N, Li Z, Lai SS, Zhao LY. Low-molecular-weight-glycosaminoglycan derivative containing terminal 2,5-anhydrated talose or derivate thereof特許6248179[日本授權(quán)2017-11-24]
Zhao JH, Kang H, Wu MY, Zeng WZ, Li Z, Gao Y, Cui J, Wang ZG, Feng HL, Yu, L. Depolymerized glycosaminoglycan from Thelenota ananas and preparation method thereof.AUS 2010324437[澳大利亞授權(quán)2015-04-02]
趙金華,劉吉開(kāi),吳明一,高娜,盧鋒,李姿. 一種低分子量糖胺聚糖衍生物及其藥物組合物和其制備方法與應(yīng)用.ZL 201310099800.9[授權(quán)2015-09-16]
劉吉開(kāi),鄭永唐,趙金華,吳明一,黃寧,李姿,高娜,文丹丹,連武,何江波.低分子量巖藻糖化糖胺聚糖的羧基還原衍生物及其制備方法與用途.ZL 201110435559.3[授權(quán)2013-10-02]
趙金華,吳明一,高娜,文丹丹,連武,李姿.一種巖藻糖化糖胺聚糖衍生物及其制備方法.ZL 2011 10318704. [授權(quán)2014- 04-09]
趙金華,吳明一,高娜,李姿,賴(lài)森森,趙龍巖.一種含末端2,5-脫水塔羅糖或其衍生物的低分子量糖胺聚糖衍生物. ZL 201310127447.0[授權(quán)2015-11-04]
趙金華,何金星,吳明一,劉峙汶,高娜,趙龍巖,李姿,盧鋒,徐麗. Fuc3S4S取代的低聚糖胺聚糖及其制備方法.CN 201410007855.7[授權(quán)2016-08-31]
吳濱,孫文武,曹沛,趙金華,楊蓮. N-喹啉基取代的β-內(nèi)酰胺類(lèi)化合物及其藥物組合物和合成方法與應(yīng)用. ZL 201310428596 [授權(quán)2016-03-02]
趙金華,吳明一,李姿.一種抗消化性潰瘍的組合物及其應(yīng)用.ZL 201310680958.5[授權(quán)2016- 04-06]
趙金華,吳明一,李姿.一種含石斛多糖和蒼術(shù)硬脂的組合物及其應(yīng)用.ZL 20131068 0378.6 [授權(quán)2016-03-30]
趙金華,，何金星，吳明一,，趙龍巖,，劉峙汶,，楊蓮，李姿,，高娜,，肖創(chuàng)，徐麗,，陳鈞,，周路坦.一種抑制內(nèi)源性因子X(jué)酶活性的寡糖類(lèi)化合物及其藥物組合物.ZL 201410549676.6[授權(quán)2017-12-01]
