姓名：沈金花

出生年月：1975年5月

職務(wù)/職稱：教授,，碩士生導(dǎo)師,，博士生導(dǎo)師

通訊地址：中南民族大學(xué)生命科學(xué)學(xué)院8-B-202

E-mail：[email protected]

一,、學(xué)習(xí)及工作簡歷

1、1994.9- 1998.7:湖北師范學(xué)院,，生物教育專業(yè),，獲理學(xué)學(xué)士學(xué)位。

2,、1998.9—2001.7:華中農(nóng)業(yè)大學(xué),，生物化學(xué)與分子生物學(xué)專業(yè)，獲理學(xué)碩士學(xué)位,。

3,、2001.9—2004.7:中國協(xié)和醫(yī)科大學(xué)，生物化學(xué)與分子生物學(xué)專業(yè),，獲理學(xué)博士學(xué)位,。

4、2006.2-2011.2：美國Case Western Reserve University醫(yī)學(xué)院,，從事博士后研究,。

5、2011.08-至今：中南民族大學(xué)生命科學(xué)學(xué)院,，工作,。

二、主要社會兼職

湖北省及武漢市生物化學(xué)與分子生物學(xué)學(xué)會常務(wù)理事

三,、科研活動及成果：

（一）主要研究方向

藥物篩選與哮喘防治,；疾病相關(guān)基因的功能研究,。

（二）主持的科研項(xiàng)目

1.國家自然科學(xué)基金面上項(xiàng)目 （批準(zhǔn)號：31771274）：MTMR14基因缺失增強(qiáng)哮喘氣道高反應(yīng)及其機(jī)理研究。執(zhí)行年限：2018.01-2021.12.資助經(jīng)費(fèi)：72萬元,。

2.國家自然科學(xué)基金面上項(xiàng)目（批準(zhǔn)號：81170227）：磷酸肌醇磷酸酶MTMR14對心肌肥厚的影響及分子機(jī)制研究。執(zhí)行年限：2012.01-2015.12,。資助經(jīng)費(fèi)：57萬元,。

3.作為合作單位承擔(dān)國家科技支撐計劃子項(xiàng)目一項(xiàng)（批準(zhǔn)號：2012BAI39B01）：建立基因工程小鼠模型新品系。執(zhí)行年限：2012.01-2014.12,。資助經(jīng)費(fèi)：60萬元,。

4.湖北省杰出青年基金項(xiàng)目(批準(zhǔn)號：2012FFA028)：新型磷酸酶MTMR14在動脈粥樣硬化中的作用及其機(jī)制研究，2013.01-2015.12,。資助經(jīng)費(fèi)：10萬元,。

5.留學(xué)回國人員科技活動項(xiàng)目擇優(yōu)資助項(xiàng)目（優(yōu)秀類）。資助經(jīng)費(fèi)：8萬元,。

6.免疫類體外診斷試劑原材料性能評價體系建立及實(shí)施項(xiàng)目,。橫向項(xiàng)目。執(zhí)行年限：2021.12-2024.12.合同經(jīng)費(fèi)：50萬元,。

7.免疫類體外診斷試劑盒的研發(fā),。橫向項(xiàng)目。執(zhí)行年限：2023.10-2025.10.合同經(jīng)費(fèi)17萬元,。

（三）代表性論文

1.PP121, a dual inhibitor of tyrosine and phosphoinositide kinases relieves airway hyperresponsiveness, musus hypersecretion and inflammation in a murine asthma model. Wei Li^#, Lu Xue^#, Changsi Peng, Ping Zhao, Yongbo Peng, Weiwei Chen, Wenyi Wang andJinhua Shen*.Molecular Medicine. 2023 Nov 7;29(1):154. doi: 10.1186/s10020-023-00748-w.

2.Duloxetine HCl alleviates asthma symptoms by regulating PI3K/AKT/mTOR and Nrf2/HO-1 signaling pathways. Changsi Peng^#, Lu Xue^#, Yanling Yue, Weiwei Chen, Wenyi Wang andJinhua Shen*. Inflammation.2023 Dec;46(6):2449-2469.doi: 10.1007/s10753-023-01892-5.

3.Shunbo Shi^#, Lu Xue^#, Shuhui Han, Haiting Qiu, Yongbo Peng, Ping Zhao, Qing-Hua Liu,Jinhua Shen*. Anti-contractile and anti-inflammatory effects of diacerein on isolated mouse airways smooth muscle and mouse asthma model.Front. Pharmacol.2020, Sep 4; 11:560361. doi: 10.3389/fphar.2020.560361.

4.Wen N^#, Xue L^#, Yang Y, Shi S, Liu QH, Cai C,Shen J*. Coptisine, a protoberberine alkaloid, relaxes mouse airway smooth muscle via blockade of VDLCCs and NSCCs.Biosci Rep.2020 Feb 28:40(2).doi: 10.1042/BSR20190534.

5.Chen C^#, Yang Y^#, Yu MF^#, Shi S, Han S, Liu QH, Cai C,Shen J*. Relaxant action of diclofenac sodium on mouse airway smooth muscle.Front Pharmacol. Jun 18:10:608, 2019.doi: 10.3389/fphar.2019.00608.

6.Yang Y^#, Chen WW^#, Wen N, Cai C, Liu Q-H,Shen J*. Benidipine, an anti-hypertensive drug, relaxes mouse airway smooth muscle.Life Sciences.2019, 227: 74-81.doi: 10.1016/j.lfs.2019.04.036.

7.Wen N^#, Yu MF^#, Liu J^#, Cai C, Liu QH,Shen J*.Deficiency of MTMR14 impairs male fertility in Mus musculus.PLoS One. 2018 Nov 9;13(11):e0206224. doi: 10.1371/journal.pone.0206224. eCollection 2018.

8.Jun Huang^#, Liqun Ma^#, Yongle Yang, Nana Wen, Wan Zhou, Congli Cai, Qing-Hua Liu andJinhua Shen*.Chloroform extract of Artemisia annua L. (CEAA) relaxes mouse airway smooth muscle.Evidence-Based Complementary and Alternative Medicine.2017 Nov 12;2017:9870414. doi: 10.1155/2017/9870414(SCI, IF:2.175).

9.Xiao Yang^#, Meng-Fei Yu^#, Jun Lei^#, Yong-Bo Peng, Ping Zhao, Lu Xue, Weiwei Chen, Li-Qun Ma, Qing-Hua Liu,Jinhua Shen*.Nuciferine relaxes tracheal rings via the blockade of VDLCC and NSCC channels.Planta Medica.2018 Jan. 84(2):83-90.doi: 10.1055/s-0043-118178.(SCI, IF:2.342).

10.Honghao Tan^#, Jun Lei^#, Lu Xue^#, Congli Cai, Qing-hua Liu,Jinhua Shen*. Relaxing effects of TSU-68, an antiangiogenic agent, on mouse airway smooth muscle.Cellular Physiology and Biochemistry.2017Apr 27;41(6):2350-2362.doi: 10.1159/000475653.(SCI, IF:4.465).

11.Xiao Yang^#, Lu Xue^#, Qingyang Zhao, Congli Cai, Qing-Hua Liu* andJinhua Shen*. Nelumbo nucifera leaves extracts inhibit mouse airway smooth muscle contraction.BMC Complementary and Alternative Medicine. 2017 Mar 20; 17(1):159.doi: 10.1186/s12906-017-1674-7.(SCI, IF:1.877).

12.Yin L^#, Yong-Bo P^#, Meng-Fei Y, Weiwei C, Ping Z, Lu X, Li-Qun M, Congli C, Qing-Hua L*,Jinhua S*. Mice lacking myotubularin-related protein 14 show accelerated high-fat diet-induced lipid accumulation and inflammation.J Physiol Biochem. 2016 Nov 2.doi: 10.1007/s13105-016-0520-6.(SCI, IF:2.054).

13.Yin Lv^#, Lu Xue^#Congli Cai, Qing-Hua Liu, andJinhua Shen*. Deficiency of Myotubularin-related Protein 14 Influences Body Weight, Metabolism, and Inflammation in an Age-dependent Manner.Cell & Bioscience. 2015, Dec, 21, 5(69):1-15, DOI 10.1186/s13578-015-0062-6. (SCI, IF:3.63)

14.Jing Liu^#, Yin Lv^#, Qing-Hua, Liu, Cheng-kui Qu,Jinhua Shen*. Deficiency of MTMR14 promotes autophagy and proliferation of mouse embryonic fibroblasts.Molecular and Cellular Biochemistry.2014 Jul;392(1-2):31-7. doi: 10.1007/s11010-014-2015-5. (SCI, IF:2.3)

15.Congli Cai#, Jing Liu#, Chao Wang, andJinhua Shen*. KHDC1A, a novel translational repressor, induces endoplasmic reticulum-dependent apoptosis,DNA and Cell Biology, 2012 Sep, 31(9): 1447-1457. (SCI, IF: 2.159)

16..Zheng H, Yu WM,Shen J, Kang S, Hambardzumyan D, Li JY, Shen Y, Kenney AM, Chen J, Qu CK*.Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development.Sci Adv. 2018 Oct 10;4(10):eaat2681. doi: 10.1126/sciadv.aat2681. eCollection 2018 Oct.

1.Yu WM, Liu X,Shen J, Jovanovic O, Pohl EE, Gerson SL, Finkel T, Broxmeyer HE, Qu CK*. Metabolic regulation by the mitochondrial phosphatase ptpmt1 is required for hematopoietic stem cell differentiation,Cell Stem Cell, 2013 Jan 3;12(1):62-74. (SCI, IF: 27.49)

2.Shen Jinhua^#, Xia Liu^#, Wen-Mei Yu^#, Liu J, Nibbelink MG, Guo C, Finkel T, Qu CK*. A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells.Molecular and Cellular Biology,2011 Dec, 31 (24): 4902-4916.(*Equal authors) (SCI, IF: 6.188; ISSN 0270-7306)

3.Shen Jinhua^#, Yu Wen-mei^#, Brotto Marco^#,Scherman JA, Guo C, Stoddard C, Nosek TM, Valdivia HH, Qu CK*. Deficiency of MIP phosphatase induces a muscle disorder by disrupting Ca2+ homeostasis.Nature Cell Biology, 2009 Jun, 11(6): 769-76. (*Equal authors) (SCI, IF: 19.4; ISSN 1465-7392)

4.Sandra Romero-Suarez^#,Shen Jinhua^#, Leticia Brotto^#, Hall T, Mo C, Valdivia HH, Andresen J, Wacker M, Nosek TM, Qu CK, Brotto M*. Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its lose accelerates skeletal muscle aging process by altering calcium homeostasis.Aging, 2010 Aug, 2(8): 504-513. (*Equal authors) (SCI, IF: 2.964; ISSN 1945-4589)

（四）授權(quán)發(fā)明專利

1.蘿芙木乙醇提取物在制備用于舒張預(yù)收縮的氣管平滑肌藥物中的應(yīng)用,。沈金花，李威,。專利授權(quán)號：ZL2021 1 0112926.X,。專利授權(quán)日：2022.06.07。

2.白鮮堿在制備用于舒張預(yù)收縮的氣管平滑肌方面的藥物中的應(yīng)用,。沈金花,，韓淑慧。專利授權(quán)號：ZL 2019 1 1414040.X,。專利授權(quán)日：2020.12.22,。

3.一種青蒿氯仿提取物及其制備方法和用途。沈金花,，黃俊,。專利授權(quán)號：ZL 2017 1 0154371.9。專利授權(quán)日：2020.7.17,。

4.一種以箬葉或箬葉提取物為活性成分的藥物,。沈金花，譚鴻浩,。專利授權(quán)號：ZL 2017 1 0044938.7,。專利授權(quán)日：2020.3.27,。

5.一種檢測人類EGFR基因L861Q位點(diǎn)突變的探針和引物組合。沈金花,，黃俊,。專利授權(quán)號：ZL 2015 1 0992676.8。專利授權(quán)日：2019.1.11,。

四,、教學(xué)活動及其成果

（一）承擔(dān)課程（本科生、研究生）

《動物學(xué)》理論課及實(shí)驗(yàn)課,，本科生,；

《高級動物發(fā)育生物學(xué)》，研究生,；

《高級分子免疫學(xué)》,，研究生；

《高級分子生物學(xué)》,，研究生,。