學(xué)科專(zhuān)業(yè)：藥物化學(xué)
研究方向：天然藥物化學(xué)/真菌天然產(chǎn)物細(xì)胞生物學(xué)行為研究
電子郵箱：[email protected]
一,、教育和工作簡(jiǎn)歷：
1.2020/1-至今,，中南民族大學(xué)，藥學(xué)院,，教授，博士生導(dǎo)師
2.2019/7-2020/6，德國(guó)萊布尼茲漢諾威大學(xué),，訪問(wèn)學(xué)者
3.2015/7-2019/12，中南民族大學(xué),，藥學(xué)院,，副教授，碩士生導(dǎo)師
4.2010/7-2015/6,，中國(guó)科學(xué)院昆明植物研究所,，植物化學(xué)與西部植物資源持續(xù)利用國(guó)家重點(diǎn)實(shí)驗(yàn)室，副研究員
5.2005/9–2010/6,，中國(guó)科學(xué)院昆明植物研究所,，碩博連讀，藥物化學(xué),，博士
6.2000/9–2004/7,，西南大學(xué)，學(xué)士
二,、研究方向：
1.藥用植物化學(xué)成分的結(jié)構(gòu)與功能
2.真菌天然產(chǎn)物的結(jié)構(gòu)與功能,。主要研究特色為真菌特有天然產(chǎn)物的結(jié)構(gòu)、功能及其生物合成。
三,、主要榮譽(yù),、獲獎(jiǎng)和社會(huì)兼職：
國(guó)家民委中青年英才培養(yǎng)計(jì)劃；中國(guó)科學(xué)院盧嘉錫青年人才獎(jiǎng),；中南民族大學(xué)第七屆三育人標(biāo)兵,；中國(guó)科學(xué)院院長(zhǎng)優(yōu)秀獎(jiǎng)；中國(guó)科學(xué)院青年創(chuàng)新促進(jìn)會(huì)會(huì)員,；分獲云南省自然科學(xué)獎(jiǎng)勵(lì)一,、二等獎(jiǎng)；Journal of Fungi,、Natural Products and Bioprospecting和Food & Medicine Homology期刊編委,；中國(guó)菌物學(xué)會(huì)菌物化學(xué)專(zhuān)業(yè)委員會(huì)副主任；湖北省藥學(xué)會(huì)藥化專(zhuān)委會(huì)委員
四,、學(xué)術(shù)研究：
從事藥用植物,、真菌天然產(chǎn)物及其功能研究。聚焦真菌特有天然產(chǎn)物的結(jié)構(gòu)及其功能,，尤其是真菌特有聚酮和萜類(lèi)分子,，發(fā)現(xiàn)具有獨(dú)特結(jié)構(gòu)的抗炎活性分子“口蘑三萜”，發(fā)現(xiàn)具有顯著鎮(zhèn)痛活性的真菌特有二萜等,。獲得新的天然產(chǎn)物700余個(gè),，多個(gè)分子被評(píng)為研究熱點(diǎn)。主持國(guó)家自然科學(xué)基金,、省部級(jí)項(xiàng)目等科研基金13項(xiàng),，在Org Lett，Org Chem Front,J Org Chem,，J Nat Prod,，J Agri Food Chem等多種學(xué)術(shù)期刊以第一作者或通訊作者發(fā)表研究論文130余篇。
（一）主要科研基金：
1.國(guó)家自然科學(xué)基金面上項(xiàng)目（2022）：真菌特有g(shù)uanacastane型二萜結(jié)構(gòu)及其鎮(zhèn)痛作用研究（22277147）,，主持,。
2.國(guó)家自然科學(xué)基金面上項(xiàng)目（2018）：“口蘑三萜”的挖掘及其抗炎作用研究（81872762），主持,。
3.國(guó)家自然科學(xué)基金項(xiàng)目（2011）：四種有毒高等真菌毒性成分挖掘及毒性評(píng)價(jià)（81102346）,，主持。
4.中央高?；究蒲袠I(yè)務(wù)費(fèi)專(zhuān)項(xiàng)資金重點(diǎn)培育項(xiàng)目：口蘑屬三萜分子抗炎先導(dǎo)化合物的發(fā)現(xiàn),，主持。
（二）發(fā)表的主要研究論文：
1.Juan He, Jiao-Xian Du, Qian-Ru Zhao, Ya-Pei Liu, Yan-Long Yang,* Ji-Kai Liu,*Tao Feng*. Biochemical and genetic basis of guanacastane diterpene biosynthesis in basidiomycete fungi.Organic Letters2023, 25, 5345-5349.
2.Jing Li, Wen-Xuan Wang, Zheng-Hui Li, Juan He, Rong Huang, Yong-Sheng Zheng, Lan-Qing Li, Xian Wang,Tao Feng*, Ji-Kai Liu*. Xylaridines C and D, unusual thiopyranodipyridine alkaloids from the fungusXylaria longipes.Organic Letters2019, 21, 6145?6148.
3.Jing Li, Wen-Xuan Wang, He-Ping Chen, Zheng-Hui Li, Juan He, Yong-Sheng Zheng, Huan Sun, Rong Huang, Qing-Xia Yuan, Xian Wang,Tao Feng*, Ji-Kai Liu*. (±)-Xylaridines A and B, highly conjugated alkaloids from the fungus Xylaria longipes.Organic Letters2019, 21, 1511-1514.
4.Wen-Xuan Wang, Xin-Xiang Lei, Hong-Lian Ai, Xue Bai, Jing Li, Juan He, Zheng-Hui Li, Yong-Sheng Zheng,Tao Feng*, Ji-Kai Liu*.Cytochalasans from the endophytic fungusXylaria cf. curtawith resistance reversal activity against fluconazole-resistantCandida albicans.Organic Letters2019, 21, 1108?1111.
5.Wen-Xuan Wang, Xin-Xiang Lei, Yan-Ling Yang, Zheng-Hui Li, Hong-Lian Ai, Jing Li,*Tao Feng,* Ji-Kai Liu,* Xylarichalasin A, a halogenated hexacyclic cytochalasan from the fungusXylaria cf. curta.Organic Letters2019, 21, 6957-6960.
6.Tao Feng, Kai-Ting Duan, Shi-Jun He, Bin Wu, Yong-Sheng Zheng, Hong-Lian Ai, Zheng-Hui Li, Juan He, Jian-Ping Zuo*, Ji-Kai Liu*.Ophiorrhines A and B, two immunosuppressive monoterpenoid indole alkaloids fromOphiorrhiza japonica.Organic Letters2018, 20, 7926–7928
7.Wei Li, Juan He,Tao Feng*, Hui-Xiang Yang, Hong-Lian Ai, Zheng-Hui Li, Ji-Kai Liu*.Antroalbocin A, an antibacterial sesquiterpenoid from higher fungusAntrodiella albocinnamomea,Organic Letters2018, 20, 8019–8021
8.Hui-Xiang Yang, Hong-Lian Ai,Tao Feng*, Wen-Xuan Wang, Bin Wu, Yong-Sheng Zheng, Huan Sun, Juan He, Zheng-Hui Li, Ji-Kai Liu*.Trichothecrotocins A–C, antiphytopathogenic agents from potato endophytic fungusTrichothecium crotocinigenum.Organic Letters2018, 20, 8069–8072
9.Tao Feng,Xue-Mei Li,Jun He,Hong-Lian Ai,He-Ping Chen,Xiao-Nian Li, Zheng-Hui Li, and Ji-Kai Liu,Nicotabin A, a sesquiterpenoid derivative fromNicotiana tabacum.Organic Letters2017,19, 5201?5203.
10.Tao Feng, Yan Li, Ya-Ping Liu, Xiang-Hai Cai, Yuan-Yuan Wang,and Xiao-Dong Luo,Melotenine A, a cytotoxic monoterpenoid indole alkaloid fromMelodinus tenuicaudatus,Organic Letters2010, 12(5),968-971.
11.Tao Feng, Xiang-Hai Cai, Yan Li, Yuan-Yuan Wang, Ya-Ping Liu, Ming-Jin Xie,and Xiao-Dong Luo,Melohenines A and B, two unprecedented alkaloids fromMelodinus henryi,Organic Letters2009, 11(21),4834-4837.
12.Jin-Tao Ma, Xin-Yue Dong, Zheng-Hui Li, He Yan, Juan He,* Ji-Kai Liu,*Tao Feng*. Antibacterial metabolites from kiwi endophytic fungusFusarium tricinctum, a potential biocontrol strain for kiwi canker disease.Journal of Agricultural and Food Chemistry2023, 71, 7679-7688.
13.Hong-Lian Ai, Bao-Bao Shi, Wei Li, Juan He, Zheng-Hui Li,Tao Feng*, Ji-Kai Liu*. Bipolarithizole A, an antifungal phenylthiazole-sativene merosesquiterpenoid from the potato endophytic fungusBipolaris eleusines.Organic Chemistry Frontiers2022, 9, 1814-1918.
14.Ying Huang, Shuai-Bing Zhang, He-Ping Chen, Zhen-Zhu Zhao, Zhong-Yu Zhou, Zheng-Hui Li,Tao Feng*, Ji-Kai Liu*.New acetylenic acids and derivatives from the edible mushroomCraterellus lutescens(Cantharellaceae).Journal of Agricultural and Food Chemistry2017, 65, 3835?3841.
15.He-Ping Chen, Zhen-Zhu Zhao, Zheng-Hui Li, Ying Huang, Shuai-Bing Zhang, Yang Tang, Jian-Neng Yao, Lin Chen, Masahiko Isaka,Tao Feng*, Ji-Kai Liu*,Anti-proliferative and anti-inflammatory lanostane triterpenoids from the Polish edible mushroomMacrolepiota procera.Journal of Agricultural and Food Chemistry2018, 66, 3146-3154.
16.Tao Feng,Jin-Long Cai,Xue-Mei Li,Zhong-Yu Zhou,Zheng-Hui Li,and Ji-Kai Liu,Chemical constituents and their bioactivities of mushroomPhellinus rhabarbarinus.Journal of Agricultural and Food Chemistry2016, 64, 1945?1949.
17.Tao Feng, Jia Su, Zhi-Hui Ding, Yong-Tang Zheng, Yan Li, Ying Leng, and Ji-Kai Liu, Chemical constituents and their bioactivities of “Tongling White Ginger” (Zingiber officinale),Journal of Agricultural and Food Chemistry2011, 59, 11690-11695.
18.Shuai-bing Zhang, Ying Huang, Shi-jun He, He-ping Chen, Bin Wu, Shan-yong Li, Zhen-zhu Zhao, Zheng-hui Li, Xian Wang, Jian-ping Zuo,Tao Feng*, Ji-Kai Liu*.Heterocyclic compounds from the mushroomAlbatrellus confluensand their inhibitions against lipopolysaccharides-induced B lymphocyte cell proliferation.Journal of Organic Chemistry2018, 83, 10158?10165.（二區(qū)top）
19.Zhen-Zhu Zhao, He-Ping Chen,Bin Wu,Ling Zhang,Zheng-Hui Li,Tao Feng*, Ji-Kai Liu*.Matsutakone and matsutoic acid, two (nor)steroids with unusual skeletons from the edible mushroomTricholoma matsutake.Journal of Organic Chemistry2017, 82, 7974?7979.（二區(qū)top）
20.Ming-Xuan Gao, Feng Wu, Si-Qiong Teng, He-Ping Chen, Zheng-Hui Li, Juan He,*Tao Feng,* Ji-Kai Liu*. Triquinane sesquiterpene glycosides from the basidiomyceteAntrodiella zonata.Journal of Natural Products2023, 86, 1736-1745.
21.Bao-bao Shi, Hong-Lian Ai, Kai-Ting Duan,Tao Feng*, Ji-Kai Liu*. Ophiorrhines F and G, key biogenetic intermediates of ophiorrhine alkaloids fromOphiorrhiza japonicaand their immunosuppressant activities.Journal of Natural Products2022, 85, 453-457.
22.Juan He, Rui Ma, Zheng-Hui Li,Tao Feng*, Ji-Kai Liu*. Taccachatrones A?G, highly oxidized steroids from the rhizomes ofTacca chantrieriiand their cytotoxicity assessment.Journal of Natural Products2021, 84, 2265?2271.
23.Meng Wang, Jiao-Xian Du, Yang Hui-Xiang, Quan Dai, Ya-Pei Liu, Juan He, Yi Wang, Zheng-Hui Li,Tao Feng,*Ji-Kai Liu*.Sesquiterpenoids from cultures of the basidiomycetesIrpex lacteus.Journal of Natural Products2020, 83, 1524-1531.
24.Ya-Pei Liu, Quan Dai, Wen-Xuan Wang, Juan He, Zheng-Hui Li,Tao Feng,* Ji-Kai Liu, Psathyrins: antibacterial diterpenoids fromPsathyrella candolleana.Journal of Natural Products2020, 83, 1725-1729.
25.Tao Feng,Xiao-Qing Gan,Yun-Li Zhao,Shuai-Bing Zhang,He-Ping Chen,Juan He,Yong-Sheng Zheng,Huan Sun,Rong Huang,Zheng-Hui Li*,Ji-Kai Liu*.Tricholopardins A and B, anti-inflammatory terpenoids from the fruiting bodies ofTricholoma pardinum.Journal of Natural Products2019, 82, 45?50.
26.Tao Feng, Xiang-Hai Cai,Ya-Ping Liu,Yan Li,Yuan-Yuan Wang, Xiao-Dong Luo,Melodinines A–G, monoterpenoid indole alkaloids fromMelodinus henryi,Journal ofNaturalProducts2010, 73, 22-26.
27.Tao Feng, Yan Li, Yuan-Yuan Wang, Xiang-Hai Cai, Ya-Ping Liu, Xiao-Dong Luo, Cytotoxic indole alkaloids fromMelodinus tenuicaudatus,Journal ofNaturalProducts2010, 73, 1075-1079.
28.Tao Feng, Yan Li, Xiang-Hai Cai, Xun Gong, Ya-Ping Liu, Rong-Ting Zhang, Xiang-Yun Zhang, Qin-Gang Tan and Xiao-Dong Luo, Monoterpenoid indole alkaloids fromAlstonia yunnanensis,Journal ofNaturalProducts2009,72,1836-1841.
29.Fa-Lei Zhang,Tao Feng*. Diterpenes specially produced by fungi: Structures, biological activities and biosynthesis (2010–2020).Journal of Fungi2022, 8, 244.
30.Quan Dai, Fa‐Lei Zhang,Tao Feng*. Sesquiterpenoids specially produced by fungi: structures, biological activities, chemical and biosynthesis (2015–2020).Journal of Fungi2021, 7, 1026.
（三）近年授權(quán)專(zhuān)利：
1.馮濤,、劉吉開(kāi),、李正輝,，口蘑菌素甲及其制備方法與應(yīng)用、口蘑菌素乙及其制備方法與應(yīng)用, ZL201810010131.6
2.馮濤,、劉吉開(kāi),、何雋、李正輝,、石晨,，口蘑三萜化合物、其制備方法,、提取物及其應(yīng)用, ZL202010980531.7
3.馮濤,、劉吉開(kāi)、楊會(huì)祥,，一種二萜類(lèi)衍生物及其制備方法與鎮(zhèn)痛藥物,、小脆柄菇發(fā)酵得物及其乙酸乙酯萃取液，ZL202210290942.2
