姓名：劉慶華
職務(wù)/職稱：教授
通訊地址：中南民族大學(xué)生科院8樓D區(qū)307室
聯(lián)系電話： 027-67842576
E-mail：[email protected]
一,、學(xué)習(xí)及工作簡歷：
學(xué)習(xí)
1981.9-1986.6: 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院臨床醫(yī)學(xué)兒科專業(yè)，獲醫(yī)學(xué)學(xué)士學(xué)位,。
1988.9-1991.6: 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院生理學(xué)專業(yè),，獲醫(yī)學(xué)碩士學(xué)位,。
1995.6-2000.8: 德國科隆, 科隆大學(xué)(Cologne University)醫(yī)學(xué)院, 獲醫(yī)學(xué)博士學(xué)位。
工作
1986.7-1988.9: 山東大學(xué)醫(yī)學(xué)院教務(wù)處醫(yī)學(xué)教育研究室,，助教,。
1991.9-1995.6: 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院生理系，講師,。
2000.6-2003.12: 美國費(fèi)城, 賓夕法尼亞大學(xué)動(dòng)物醫(yī)學(xué)院生物病理系,，副研究員。
2004.1-2010.3: 美國紐約洲奧爾巴尼, 奧爾巴尼醫(yī)學(xué)院心血管科學(xué)中心,，助理教授,。
2010.3-至今中南民族大學(xué)生命科學(xué)學(xué)院醫(yī)學(xué)生物研究所，教授、所長,。
二,、主要社會(huì)兼職
湖北省細(xì)胞生物學(xué)會(huì)理事
湖北省生理學(xué)會(huì)理事
湖北省實(shí)驗(yàn)動(dòng)物學(xué)會(huì)理事
三、科研活動(dòng)及成果：
（一）主要研究方向
分子及離子信號(hào)的產(chǎn)生及轉(zhuǎn)導(dǎo)機(jī)制及在干細(xì)胞分化發(fā)育,，免疫系統(tǒng),，肌肉系統(tǒng)中的生理和病理作用，以及藥物研發(fā),。
（二）主持或參與的科研項(xiàng)目
1. 主持：國家自然科學(xué)基金面上項(xiàng)目(31571200), 2016-2019年,；
2. 主持：國家自然科學(xué)基金面上項(xiàng)目(30971514), 2010-2012年；
3. 主持：國家自然科學(xué)基金主任基金(31140087), 2012-2012年,；
4. 參與：科技部“973”(2011CB809100), 2011-2015,。
（三）科研成果及榮譽(yù)
1、2010年湖北省自然科學(xué)二等獎(jiǎng),。
（四）代表性論文：（*通訊作者）
1. Zhou Q, Yang X, Xiong M, Xu X, Zhen L, Chen W, Wang Y, Shen J, Zhao P*, Liu QH*. Chloroquine Increases Glucose Uptake via Enhancing GLUT4 Translocation and Fusion with the Plasma Membrane in L6 Cells. Cell Physiol Biochem. 2016;38(5):2030-40. doi: 10.1159/000445562. Epub 2016 May 9. PMID: 27160165
2. Lv Y, Xue L, Cai C, Liu QH, Shen J. Deficiency of myotubularin-related protein 14 influences body weight, metabolism, and inflammation in an age-dependent manner. Cell Biosci. 2015 Dec 21;5:69. doi: 10.1186/s13578-015-0062-6. eCollection 2015. PMID: 26697164
3. Song T, Hao Q, Zheng YM, Liu QH, Wang YX. Inositol 1,4,5-trisphosphate activates TRPC3 channels to cause extracellular Ca2+ influx in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 9:ajplung.00148.2015. doi: 10.1152/ajplung.00148.2015. [Epub ahead of print]
(PMID: 26453517)
4. Tan L, Chen W, Wei MY, Shen J, Yu MF, Yang G, Guo D, Qin G, Ji G, Liu QH*.
Relaxant action of plumula nelumbinis extract on mouse airway smooth muscle.
Evid Based Complement Alternat Med. 2015;2015:523640. doi: 10.1155/2015/523640. Epub 2015 Feb 11. PMID:25763092
5. Xu JC, Peng YB, Wei MY, Wu YF, Guo D, Qin G, Ji G, Shen J, Liu QH*. Chloroquine Inhibits Ca Signaling in Murine CD4(+) Thymocytes. Cell Physiol Biochem. 2015;36(1):133-40. doi: 10.1159/000374058. Epub 2015 Apr 27.
(PMID: 25925287)
6. Wei MY, Xue L, Tan L, Sai WB, Liu XC, Jiang QJ, Shen J, Peng YB, Zhao P, Yu MF, Chen W, Ma LQ, Zhai K, Zou C, Guo D, Qin G, Zheng YM, Wang YX, Ji G, Liu QH*. Involvement of large-conductance Ca2+-activated K+ channels in chloroquine-induced force alterations in pre-contracted airway smooth muscle.
PLoS One. 2015 Mar 30;10(3):e0121566. doi: 10.1371/journal.pone.0121566. eCollection 2015. PMID: 25822280 Free PMC Article
7. Zhou J, Cheng M, Boriboun C, Ardehali MM, Jiang C, Liu Q, Han S, Goukassian DA, Tang YL, Zhao T, Zhao M, Cai L, Richard S, Kishore R, Qin G. Inhibition of Sam68 triggers adipose tissue browning. J Endocrinol. 2015 May 1. pii: JOE-14-0727. [Epub ahead of print]. (PMID: 25934704)
8. Wu M, Zhou J, Cheng M, Boriboun C, Biyashev D, Wang H, Mackie A, Thorne T, Chou J, Wu Y, Chen Z, Liu Q, Yan H, Yang Y, Jie C, Tang YL, Zhao TC, Taylor RN, Kishore R, Losordo DW, Qin G. E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expression. Cardiovasc Res. 2014 Dec 1;104(3):412-22. doi: 10.1093/cvr/cvu222. Epub 2014 Oct 23. (PMID: 25341896)
9. Savoia CP, Liu QH, Zheng YM, Yadav VR, Zhang Z, Wu LG, Wang YX Calcineurin upregulates local Ca2+ signaling through ryanodine receptor-1 in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 19. pii: ajplung.00149.2014. [Epub ahead of print] PMID: 25239916 [PubMed - as supplied by publisher]. (PMID: 25239916)
10. Ting Zhang, Xiao-Jing Luo, Wen-Bo Sai, Meng-Fei Yu, Wen-Er Li, Yun-Fei Ma, Weiwei Chen, Kui Zhai, Gangjian Qin, DongLin Guo, Yun-Min Zheng, Yong-Xiao Wang, Jin-Hua Shen, Guangju Ji, Qing-Hua Liu*. Non-selective cation channels mediate chloroquine-induced relaxation in precontracted mouse airway smooth muscle. Plos One, 2014 Jul 3;9(7):e101578. doi: 10.1371/journal.pone.0101578. (PMID: 24992312)
11. Guo D, Yu M, Liu QH, Cox RH, Liu T, Yan GX. Ventricular hypertrophy amplifies transmural dispersion of repolarization by preferentially increasing the late sodium current in endocardium. J Electrocardiol. 2014 Apr 13. pii: S0022-0736(14)00127-7. doi: 10.1016/j.jelectrocard.2014.04.004. [Epub ahead of print] PMID: 24813353 [PubMed - as supplied by publisher]. (PMID: 24813353)
12. Liu J, Lv Y, Liu QH, Qu CK, Shen J. Deficiency of MTMR14 promotes autophagy and proliferation of mouse embryonic fibroblasts. Molecular and cellular biochemistry, 2014 Mar 13. [Epub ahead of print]. (PMID: 24623267)
13. Zhai K, Chang Y, Wei B, Liu Q-H, Leblais V, Fischmeister R, Ji G. Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms. Cellular Signalling. 26(5):1001-10, 2014 May. (PMID: 24463006)
14. Sai WB, Yu MF, Wei MY, Lu Z, Zheng YM, Wang YX, Qin G, Guo D, Ji G, Shen J, Liu Q-H*. Bitter tastants induce relaxation of rat thoracic aorta precontracted with high K(+). Clinical and Experimental Pharmacology & Physiology. 41(4):301-8, 2014. (PMID:24552423)
15. Ge YB, Dai Q, Wan DR, Liu Q-H*, Mei ZN. Relaxant effect of 1-butanol fraction from Elaeagnus pungens leaf through inhibiting l-type Ca(2+) channel on guinea pig tracheal smooth muscle. J Ethnopharmacol. 150 (1):196-201, 2013. (PMID:23988619)
16. Tuo QR, Ma YF, Chen W, Luo XJ, Shen J, Guo D, Zheng YM, Wang YX, Ji G, Liu Q-H*. Reactive oxygen species induce a Ca(2+)-spark increase in sensitized murine airway smooth muscle cells. Biochem Biophys Res Commun. 434(3):498-502, 2013. (PMID:23583396)
17. Li WE, Chen W, Ma YF, Tuo QR, Luo XJ, Zhang T, Sai WB, Liu J, Shen J, Liu ZG, Zheng YM, Wang YX, Ji G, Liu Q-H*. Methods to measure and analyze ciliary beat activity: Ca2+ influx-mediated cilia mechanosensitivity. Pflügers Archiv-European Journal of Physiology. 464(6):671-80, 2012. (PMID:23053477)
四,、教學(xué)活動(dòng)及其成果：
（一）承擔(dān)課程（本科生、研究生）
《動(dòng)物生理學(xué)》,，生科院,，本科生；
《科技論文學(xué)作》,，生科院,，研究生；
《現(xiàn)代傳染病學(xué)》,，所有院系,，在校學(xué)生。
（二）教學(xué)成果及榮譽(yù)
無
五,、社會(huì)服務(wù)活動(dòng)及其成果
（一）參與項(xiàng)目及活動(dòng)
無
（二）成果轉(zhuǎn)化及社會(huì)效益
無
